Reactome | Regulation of CDH11 function

Regulation of CDH11 function

Stable Identifier

R-HSA-9762292

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type II Classical Cadherins (Homo sapiens)
        
        Regulation of CDH11 Expression and Function (Homo sapiens)
        
        Regulation of CDH11 function (Homo sapiens)

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Like other classical cadherins, CDH11 associates with several catenin proteins through its intracellular domain, which is thought to play a role in the establishment and regulation of adherens junctions. These catenin proteins include CTNND1 (also known as p120 catenin or delta-catenin), CTNNB1 (beta-catenin), JUP (Junction Plakoglobin, also known as gamma-catenin), and CTNNA1 (alpha-catenin) (Straub et al. 2003; Kiener et al. 2006; Ortiz et al. 2015; Lee et al. 2018).

CDH11, through its C terminus, also forms a complex with angiomotin (AMOT) isoform p80 (AMOT-2), which is implicated in CDH11-mediated cell migration and tumor cell invasiveness (Levchenko et al. 2004; Jiang et al. 2006; Yi et al. 2011; Ortiz et al. 2015; Lee et al. 2018).

Through its extracellular region, CDH11 binds to the C terminal fragment of ANGPTL4 (Angiopoietin-like-4), commonly known as cANGPTL4, which is implicated in the regulation of wound healing. The variant isoform of CDH11 (CDH11v), an 85 kDa membrane-bound protein produced as a result of alternative splicing (Kawaguchi et al. 1999), can compete with the canonical CDH11 for cANGPTL4 binding (Teo et al. 2017).

Literature References

PubMed ID	Title	Journal	Year
14625392	A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells Spring, H, Schnoelzer, M, Kuhn, C, Korf, U, Boda, J, Hatzfeld, M, Franke, WW, Straub, BK, Kempf, T	J Cell Sci	2003
14730344	Angiomotin expression promotes hemangioendothelioma invasion Bratt, A, Holmgren, L, Levchenko, T, Arbiser, JL	Oncogene	2004
21481793	A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions Shimono, A, Yi, C, Kissil, JL, Avila, JL, Stemmer-Rachamimov, A, Persson, NL, Marmorstein, R, Fera, D, Christian, N, Holmgren, L, Troutman, S, Speicher, DW	Cancer Cell	2011
25466890	Angiomotin is a novel component of cadherin-11/β-catenin/p120 complex and is critical for cadherin-11-mediated cell migration Liu, HC, Lin, SH, Bilen, MA, Yu, G, Lee, YC, Cho, H, Lin, SC, Yu-Lee, LY, Ortiz, A	FASEB J	2015
16430777	Angiomotin and angiomotin like proteins, their expression and correlation with angiogenesis and clinical outcome in human breast cancer Watkins, G, Mansel, RE, Jiang, WG, Holmgren, L, Douglas-Jones, A	BMC Cancer	2006
16525026	The cadherin-11 cytoplasmic juxtamembrane domain promotes alpha-catenin turnover at adherens junctions and intercellular motility Kiener, HP, Allen, PG, Stipp, CS, Higgins, JM, Brenner, MB	Mol Biol Cell	2006
10320525	Expression and function of the splice variant of the human cadherin-11 gene in subordination to intact cadherin-11 Machinami, R, Takeshita, S, Kawaguchi, J, Kashima, T, Imai, T, Kudo, A	J Bone Miner Res	1999
29110486	Impact of Detergents on Membrane Protein Complex Isolation Sachan, N, Martinez, J, Li, S, Lee, YC, Kürten, C, Sarr, M, Gamero-Estevez, E, Subramanian, N, Dornan, M, Bååth, JA, Kernan, J, Shan, X, Rivera, K, Pappin, D, Lin, SH, Cantoria, MJ, Ford, L, Halova, L, Bastle, RM, Bhattacharjee, S	J Proteome Res	2018
28740178	Angiopoietin-like 4 induces a β-catenin-mediated upregulation of ID3 in fibroblasts to reduce scar collagen expression Teo, DJR, Sng, MK, Teo, Z, Zhu, P, Chong, HC, Tan, NS, Chan, JSK, Wong, MTC, Phua, GZM, Choo, CC, Choong, C	Sci Rep	2017