Reactome | Regulation of CDH11 gene transcription

Regulation of CDH11 gene transcription

Stable Identifier

R-HSA-9762293

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type II Classical Cadherins (Homo sapiens)
        
        Regulation of CDH11 Expression and Function (Homo sapiens)
        
        Regulation of CDH11 gene transcription (Homo sapiens)

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The CDH11 gene consists of 14 exons, which encode two splice isoforms. Both splicing isoforms are expressed in the heart, brain, placenta, lung and bone, but not in the kidney, skeletal muscle, pancreas and liver (Okazaki et al. 1994; Kawaguchi et al. 1999). Several transcription factors have been shown to directly regulate CDH11 gene transcription, including HOXC8 (Lei et al. 2005; Lei et al. 2006; Li et al. 2014), ILF3 (Zhang et al. 2017), ZEB2 (Nam et al. 2012; Nam et al. 2014), HEYL (Liu et al. 2020), FOXF1 (Black et al. 2018), and BHLHE22 (Ross et al. 2012), and the transcription of CDH11 has also been shown to be influenced by a number of growth factors and hormones, such as FGF2 (Strutz et al. 2002; James et al. 2008), TNF (Wu et al. 2013), TGFB1 (Schneider et al. 2012; Schulte et al. 2013; Hahn et al. 2016; Cheng et al. 2018; Ruan et al. 2019; Doolin et al. 2021; Wilson et al. 2022), TGFB2 (Wecker et al. 2013; Theodossiou et al. 2019), GNRH1 (Peng et al. 2015), PTH (Yao et al. 2014), dexamethasone (Lecanda et al. 2000), progesterone (Chen et al. 1999). CDH11 can also affect TGFB1 signaling, thereby possibly creating a feedback loop (Passanha et al. 2022). Expression of mouse Cdh11 in mouse osteoblast-like cell line (MC3T3-E1) is not affected by osteogenic hormones triiodothyronine (T3) and 1,25-dihydroxyvitamin D3 at either mRNA or protein levels (Leugmayr et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
29296180	Interleukin enhancer-binding factor 3 and HOXC8 co-activate cadherin 11 transcription to promote breast cancer cells proliferation and migration Gong, C, Li, Y, Zhang, M, Kai, Y, Zhang, J, Yang, C, Zhang, Y, Zou, J, Liu, H, Xu, S	Oncotarget	2017
23951053	Cadherin-11 regulates motility in normal cortical neural precursors and glioblastoma Zhang, J, Srikanth, M, Kessler, JA, Schulte, JD, Yin, L, Chenn, A, Rich, JN, Das, S, Lathia, JD, Olson, EC	PLoS One	2013
32463580	Charactering tumor microenvironment reveals stromal-related transcription factors promote tumor carcinogenesis in gastric cancer Ni, S, Wang, H, Zhang, Q, Weng, W, Liu, H	Cancer Med	2020
22227038	ZEB2 upregulates integrin α5 expression through cooperation with Sp1 to induce invasion during epithelial-mesenchymal transition of human cancer cells Nam, EH, Kim, S, Park, YK, Lee, Y, Lee, JW	Carcinogenesis	2012
10320525	Expression and function of the splice variant of the human cadherin-11 gene in subordination to intact cadherin-11 Machinami, R, Takeshita, S, Kawaguchi, J, Kashima, T, Imai, T, Kudo, A	J Bone Miner Res	1999
29269046	TGF-β1 up-regulates cadherin-11 expression through Snail: A potential mechanism for human trophoblast cell differentiation Yi, Y, Leung, PCK, Cheng, JC, Chang, HM	Cell Signal	2018
30538046	TGFβ2-induced tenogenesis impacts cadherin and connexin cell-cell junction proteins in mesenchymal stem cells Tokle, J, Schiele, NR, Theodossiou, SK	Biochem Biophys Res Commun	2019
27574697	Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1 Combs, KA, Supp, DM, McFarland, KL, Hahn, JM	Burns Trauma	2016
30509494	CDH11 promotes liver fibrosis via activation of hepatic stellate cells Nie, Y, Wu, Y, Pan, R, Ruan, W, Shen, X	Biochem Biophys Res Commun	2019
24130169	ZEB2-Sp1 cooperation induces invasion by upregulating cadherin-11 and integrin α5 expression Nam, EH, Kim, S, Park, YK, Zhao, XF, Lee, Y, Lee, JW	Carcinogenesis	2014
23916685	Pressure and inflammatory stimulation induced increase of cadherin-11 is mediated by PI3K/Akt pathway in synovial fibroblasts from temporomandibular joint Gu, Z, Zhou, Y, Lu, H, Xu, T, Wu, M	Osteoarthritis Cartilage	2013
24003087	Effects of TGF-β2 on cadherins and β-catenin in human trabecular meshwork cells Börner, J, Han, H, Wecker, T, Schlunck, G, Grehn, F	Invest Ophthalmol Vis Sci	2013
35197532	Integrated bioinformatics analysis identifies established and novel TGFβ1-regulated genes modulated by anti-fibrotic drugs McDonald, MN, Mobley, JA, Ashish, S, Neptune, ER, Chanda, D, Kumar, PL, Wilson, AC, Thannickal, VJ, Chiles, J	Sci Rep	2022
34731044	Fibroblast to myofibroblast transition is enhanced by increased cell density Doolin, MT, Smith, IM, Stroka, KM	Mol Biol Cell	2021
24810778	HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression Huang, S, Li, Y, Liu, D, Chao, F, Kim, J, Huang, B	Oncotarget	2014
15699330	The identification of Hoxc8 target genes Ruddle, FH, Wang, H, Lei, H, Juan, AH	Proc Natl Acad Sci U S A	2005
22284184	Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly Greenberg, ME, Harrar, D, McInnes, RR, Ross, SE, Lin, Y, Hemberg, M, Mok, SI, Salogiannis, J, Atan, D, Kim, TK, Hu, L, McCord, AE, Jung, C, Cohen, S	Neuron	2012
21990376	Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-β production and epithelial to mesenchymal transition Wu, M, Agarwal, SK, Cho, SH, Schneider, DJ, Blackburn, MR, Brenner, MB, Le, TT	FASEB J	2012
10760957	Differential regulation of cadherins by dexamethasone in human osteoblastic cells Davidson, MK, Warlow, P, Shin, CS, Cheng, SL, Lecanda, F, Avioli, LV, Civitelli, R	J Cell Biochem	2000
16793922	Identification of a Hoxc8-regulated transcriptional network in mouse embryo fibroblast cells Ruddle, FH, Lei, H, Kim, MS, Juan, AH	Proc Natl Acad Sci U S A	2006
8163513	Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts Okazaki, M, Kikuno, R, Tsujimura, A, Amann, E, Takeshita, S, Kudo, A, Kawai, S	J Biol Chem	1994
18594386	Proliferation, osteogenic differentiation, and fgf-2 modulation of posterofrontal/sagittal suture-derived mesenchymal cells in vitro James, AW, Wang, R, Longaker, MT, Xu, Y	Plast Reconstr Surg	2008
11967021	Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation Neilson, EG, Müller, GA, Yang, CQ, Kalluri, R, Ziyadeh, FN, Strutz, F, Zeisberg, M	Kidney Int	2002
25794160	AP-1 Transcription Factors c-FOS and c-JUN Mediate GnRH-Induced Cadherin-11 Expression and Trophoblast Cell Invasion Leung, PC, Wang, YL, Ma, L, Zhu, H, Peng, B, Klausen, C	Endocrinology	2015
35416252	Cadherin-11 influences differentiation in human mesenchymal stem cells by regulating the extracellular matrix via the TGFβ1 pathway Passanha, FR, Geuens, T, LaPointe, VLS	Stem Cells	2022
9890746	Cadherin-11 is a hormonally regulated cellular marker of decidualization in human endometrial stromal cells Chen, GT, MacCalman, CD, Getsios, S	Mol Reprod Dev	1999
24648356	Parathyroid hormone enhances hematopoietic expansion via upregulation of cadherin-11 in bone marrow mesenchymal stromal cells Miura, M, Hishita, T, Miura, Y, Higashi, Y, Kaneko, H, Ichinohe, T, Ashihara, E, Hayashi, Y, Yao, H, Iwasa, M, Tamura, A, Yoshioka, S, Hirai, H, Maekawa, T, Sato, A	Stem Cells	2014
29642003	FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts Ren, X, Kalinichenko, VV, Milewski, D, Kalin, TV, Black, M, Xu, Y, Le, T	Cell Rep	2018
10933223	The organization of adherens junctions in mouse osteoblast-like cells (MC3T3-E1) and their modulation by triiodothyronine and 1,25-dihydroxyvitamin D3 Glantschnig, H, Klaushofer, K, Varga, F, Luegmayr, E	Histochem Cell Biol	2000