Complement factor I complex formation

Stable Identifier
R-HSA-976801
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Complement factor I complex formation
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Complement factor I (CFI) is a complex of one heavy and one light chain, both cleaved from the same precursor peptide. It inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage of the alpha chains of C4b and C3b in the presence of cofactors such as Factor H, C4b binding protein, Complement receptor 1 (CR1) or MCP (CD46).
Literature References
Participants
Input
Output
Participates
as an event of
Orthologous Events
Complement factor I complex formation (Bos taurus)
Complement factor I complex formation (Canis familiaris)
Complement factor I complex formation (Drosophila melanogaster)
Complement factor I complex formation (Gallus gallus)
Complement factor I complex formation (Mus musculus)
Complement factor I complex formation (Rattus norvegicus)
Complement factor I complex formation (Sus scrofa)
Complement factor I complex formation (Xenopus tropicalis)
Authored
Jupe, S  (2010-10-26)
Reviewed
Fraczek, LA  (2012-02-13)
Bradley, DT  (2012-02-13)
Created
Jupe, S  (2010-10-13)
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