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About
What is Reactome ?
News
Team
Scientific Advisory Board
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
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Docs
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How do I search ?
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TNF(77-233) [extracellular region]
Stable Identifier
R-HSA-976821
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
TNF, TNF-alpha, Tumor necrosis factor, TNFA_HUMAN, Cachectin
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of CEBPA (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 negatively regulates extracellular inflammatory mediators (Homo sapiens)
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of IL13-downregulated extracellular proteins (Homo sapiens)
IL13-downregulated proteins [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
Expression of IL4,IL13-downregulated extracellular genes (Homo sapiens)
IL4,IL13-downregulated extracellular proteins [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Homo sapiens)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
CLIP3 and CYLD bind TNF signaling complex (Homo sapiens)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
K63polyUb-RIPK1 is deubiquitinated (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
LUBAC ubiquitinates RIPK1 at K627 (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
OPTN recruits CYLD to the TNFR1 complex (Homo sapiens)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1 binds DENN/MADD (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:DENN-SV,MADD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Homo sapiens)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Homo sapiens)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TRAF1 binds TRAF2 within TNFR1 signaling complex (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
Soluble TNF-α binds TNFR1 (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-alpha inhibitors bind to soluble TNF trimer (Homo sapiens)
TNF-alpha inhibitors:TNF-alpha trimer, soluble form [extracellular region] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α is cleaved by ADAM17 (TACE) (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNFR1-induced NF-kappa-B signaling pathway (Homo sapiens)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNFR1-induced proapoptotic signaling (Homo sapiens)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex (Homo sapiens)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNFR1-mediated ceramide production (Homo sapiens)
TNF-α:TNFR1 binds NSMAF (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:NSMAF binds GNB2L1 (Homo sapiens)
TNF-α:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:NSMAF:GNB2L1 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Homo sapiens)
TNF-alpha:TNFR1:NSMAF:GNB2L1:SMPD2,3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:NSMAF:GNB2L1 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
TNF-α:TNFR1:NSMAF:GNB2L1 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:NSMAF [plasma membrane] (Homo sapiens)
TNF-α trimer:TNF-R1 trimer [plasma membrane] (Homo sapiens)
soluble TNF-α:TNFR1 [plasma membrane] (Homo sapiens)
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
TNF(77-233) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01375 TNF
Gene Names
TNF, TNFA, TNFSF2
Chain
chain:1-233, chain:1-39, chain:1-35, chain:50-, chain:52-, chain:77-233
Reference Genes
BioGPS Gene:7124 TNF
COSMIC (genes):TNF TNF
CTD Gene:7124 TNF
dbSNP Gene:7124 TNF
ENSEMBL:ENSG00000232810 TNF
ENSEMBL_homo_sapiens_GENE:ENSG00000204490.3 TNF
ENSEMBL_homo_sapiens_GENE:ENSG00000206439.5 TNF
ENSEMBL_homo_sapiens_GENE:ENSG00000223952.3 TNF
ENSEMBL_homo_sapiens_GENE:ENSG00000228321.3 TNF
ENSEMBL_homo_sapiens_GENE:ENSG00000228849.3 TNF
ENSEMBL_homo_sapiens_GENE:ENSG00000230108.3 TNF
ENSEMBL_homo_sapiens_GENE:ENSG00000232810.5 TNF
HGNC:11892 TNF
KEGG Gene (Homo sapiens):7124 TNF
Monarch:7124 TNF
NCBI Gene:7124 TNF
OMIM:191160 TNF
Reference Transcript
RefSeq:NM_000594.3 TNF
Other Identifiers
11721577_at
17006659
17026267
17027794
17030620
17033337
17035418
17038117
17040712
1852_at
207113_PM_s_at
207113_s_at
259_s_at
2902417
2902418
2902420
2902421
2902423
2902424
7124
8118142
8177983
8179263
A_14_P110091
A_14_P125975
A_23_P376488
A_24_P50759
GE59636
GO:0000122
GO:0000278
GO:0000976
GO:0001666
GO:0001774
GO:0001819
GO:0001891
GO:0001932
GO:0001934
GO:0001937
GO:0002020
GO:0002037
GO:0002281
GO:0002376
GO:0002439
GO:0002523
GO:0002637
GO:0002719
GO:0002876
GO:0002925
GO:0003009
GO:0003012
GO:0003013
GO:0003085
GO:0003677
GO:0005102
GO:0005125
GO:0005164
GO:0005515
GO:0005576
GO:0005615
GO:0005768
GO:0005886
GO:0005975
GO:0006006
GO:0006091
GO:0006351
GO:0006355
GO:0006629
GO:0006766
GO:0006919
GO:0006952
GO:0006954
GO:0006955
GO:0006959
GO:0007010
GO:0007154
GO:0007155
GO:0007254
GO:0007623
GO:0008285
GO:0008625
GO:0008630
GO:0009410
GO:0009612
GO:0009615
GO:0009617
GO:0009651
GO:0009750
GO:0009887
GO:0009897
GO:0009986
GO:0010033
GO:0010459
GO:0010573
GO:0010628
GO:0010629
GO:0010888
GO:0012501
GO:0014070
GO:0014823
GO:0016020
GO:0019722
GO:0023052
GO:0030154
GO:0030163
GO:0030198
GO:0030316
GO:0030730
GO:0030866
GO:0031334
GO:0031410
GO:0031622
GO:0031642
GO:0031667
GO:0032496
GO:0032715
GO:0032722
GO:0032724
GO:0032729
GO:0032731
GO:0032741
GO:0032755
GO:0032757
GO:0033138
GO:0033209
GO:0034116
GO:0034138
GO:0034250
GO:0034330
GO:0035509
GO:0035900
GO:0036005
GO:0036211
GO:0038177
GO:0042060
GO:0042127
GO:0042311
GO:0042531
GO:0042742
GO:0042802
GO:0043025
GO:0043065
GO:0043066
GO:0043068
GO:0043122
GO:0043123
GO:0043154
GO:0043226
GO:0043242
GO:0043243
GO:0043280
GO:0043406
GO:0043410
GO:0043491
GO:0043507
GO:0043525
GO:0043537
GO:0045071
GO:0045121
GO:0045123
GO:0045429
GO:0045471
GO:0045598
GO:0045599
GO:0045662
GO:0045668
GO:0045670
GO:0045672
GO:0045732
GO:0045760
GO:0045785
GO:0045834
GO:0045840
GO:0045892
GO:0045893
GO:0045930
GO:0045944
GO:0045994
GO:0046325
GO:0046330
GO:0046427
GO:0048018
GO:0048143
GO:0048566
GO:0048661
GO:0048856
GO:0048870
GO:0050708
GO:0050727
GO:0050729
GO:0050768
GO:0050793
GO:0050796
GO:0050806
GO:0050807
GO:0050830
GO:0050877
GO:0050890
GO:0050900
GO:0050901
GO:0050966
GO:0050995
GO:0051044
GO:0051046
GO:0051091
GO:0051092
GO:0051173
GO:0051222
GO:0051239
GO:0051384
GO:0051798
GO:0051897
GO:0051966
GO:0055037
GO:0055085
GO:0060252
GO:0060557
GO:0060559
GO:0060664
GO:0060693
GO:0061044
GO:0061048
GO:0065003
GO:0065008
GO:0070374
GO:0070886
GO:0071219
GO:0071222
GO:0071230
GO:0071300
GO:0071316
GO:0071346
GO:0071677
GO:0071803
GO:0072577
GO:0072659
GO:0090324
GO:0090594
GO:0097190
GO:0097191
GO:0097237
GO:0097421
GO:0097527
GO:0098542
GO:0098772
GO:0120190
GO:0140014
GO:0140374
GO:0140460
GO:0150078
GO:0150129
GO:1900017
GO:1900222
GO:1901224
GO:1901647
GO:1901671
GO:1902004
GO:1902065
GO:1902565
GO:1902894
GO:1902895
GO:1903078
GO:1903140
GO:1903347
GO:1903721
GO:1904646
GO:1904707
GO:1904996
GO:1904999
GO:1905038
GO:1905242
GO:1990268
GO:2000010
GO:2000272
GO:2000334
GO:2000343
GO:2000347
GO:2000351
GO:2000377
GO:2000573
GO:2001234
GO:2001238
GO:2001240
HMNXSV003051425
ILMN_1728106
PH_hs_0012958
TC06000371.hg
TC06002714.hg
TC6_apd_hap1000036.hg
TC6_cox_hap2000067.hg
TC6_dbb_hap3000058.hg
TC6_mann_hap4000059.hg
TC6_mcf_hap5000053.hg
TC6_qbl_hap6000058.hg
TC6_ssto_hap7000054.hg
X02910_at
g10835154_3p_a_at
Participates
as a member of
IL4,IL13-downregulated extracellular proteins [extracellular region] (Homo sapiens)
IL13-downregulated proteins [extracellular region] (Homo sapiens)
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
as a component of
TNF-α trimer, soluble form [extracellular region] (Homo sapiens)
This entity regulates
Negatively
Expression of CEBPA
(Homo sapiens)
Other forms of this molecule
TNF(52-76) [extracellular region]
TNF(1-34) [plasma membrane]
TNF(1-76) [plasma membrane]
TNF(1-233) [plasma membrane]
Inferred To
Homologues of TNF(77-233) [extracellular region]
(Danio rerio)
TNF [extracellular region]
(Bos taurus)
TNF [extracellular region]
(Canis familiaris)
TNF [extracellular region]
(Sus scrofa)
tnfa [extracellular region]
(Danio rerio)
tnfb [extracellular region]
(Danio rerio)
Tnf [extracellular region]
(Mus musculus)
Tnf [extracellular region]
(Rattus norvegicus)
tnf [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000585.2
ZINC - World Drugs
TNFA_HUMAN
OpenTargets
ENSG00000232810
ZINC - Substances
TNFA_HUMAN
ZINC - Biogenic
TNFA_HUMAN
ZINC target
P01375
PRO
P01375
PDB
3IT8
,
1TNF
,
5WUX
,
7TA3
,
4TWT
,
2ZJC
,
7KP9
,
4Y6O
,
7JRA
,
4TSV
,
5M2I
,
2TUN
,
3L9J
,
3ALQ
,
6X82
,
5YOY
,
1A8M
,
7KPB
,
6X81
,
2ZPX
,
5MU8
,
7KPA
,
2E7A
,
4G3Y
,
7TA6
,
6OP0
,
6X86
,
6OOY
,
6RMJ
,
5M2M
,
3WD5
,
7QLF
,
7AT7
,
5M2J
,
6X85
,
7ASY
,
6X83
,
5TSW
,
2AZ5
,
5UUI
,
6OOZ
,
7ATB
ZINC - Investigational
TNFA_HUMAN
ZINC - Metabolites
TNFA_HUMAN
GeneCards
P01375
HPA
ENSG00000232810-TNF
Ensembl
ENSP00000365290
,
ENST00000443707
,
ENSG00000230108
,
ENSP00000389490
,
ENSP00000389492
,
ENSG00000206439
,
ENST00000376122
,
ENSG00000228849
,
ENSG00000223952
,
ENSP00000398698
,
ENSG00000204490
,
ENST00000412275
,
ENSG00000228321
,
ENST00000383496
,
ENSP00000392858
,
ENSP00000372988
,
ENST00000449264
,
ENST00000448781
,
ENSP00000410668
,
ENSG00000232810
,
ENST00000420425
Pharos - Targets
P01375
ZINC - Predictions - Purchasable
TNFA_HUMAN
HMDB Protein
HMDBP02070
Interactors (67)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19438 TNFRSF1A
2
TNFRSF1A(41-201) [extracellular region]
(R-HSA-6785048)
TNFRSF1A(30-45) [plasma membrane]
(R-HSA-5675738)
0.939
16
UniProt:Q13546 RIPK1
20
K48polyUb-RIPK1 [cytosol]
(R-HSA-6783308)
PolyUb-RIPK1 [cytosol]
(R-HSA-6783197)
RIPK1 D324N [cytosol]
(R-HSA-9693930)
RIPK1 D324Y [cytosol]
(R-HSA-9693931)
RIPK1 D324V [cytosol]
(R-HSA-9693927)
RIPK1 D324H [cytosol]
(R-HSA-9693922)
RIPK1 [plasma membrane]
(R-HSA-937073)
K48polyUb-K571,K604,K627-RIPK1 [cytosol]
(R-HSA-9796639)
K63,Met1polyUb-p-S25-RIPK1 [cytosol]
(R-HSA-9818793)
K63,M1polyUb-RIPK1 [cytosol]
(R-HSA-9793681)
RIPK1(1-324) [cytosol]
(R-HSA-5212664)
RIPK1(325-671) [cytosol]
(R-HSA-5212671)
polyUb-K377,K604,K634-RIPK1 [cytosol]
(R-HSA-9818391)
K63,M1polyUb, p-T189-RIPK1 [cytosol]
(R-HSA-9817377)
p-S320-RIPK1 [cytosol]
(R-HSA-9815498)
p-S357-RIPK1 [cytosol]
(R-HSA-9819116)
p-S166-RIPK1 [cytosol]
(R-HSA-5218872)
K63polyUb-RIPK1 [cytosol]
(R-HSA-937021)
RIPK1 [endosome membrane]
(R-HSA-450326)
RIPK1 [cytosol]
(R-HSA-168651)
0.837
9
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.788
9
UniProt:Q13490 BIRC2
5
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2 [cytosol]
(R-HSA-50847)
0.788
5
UniProt:P01375 TNF
5
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.73
3
UniProt:Q9H0F6 SHARPIN
1
SHARPIN [cytosol]
(R-HSA-5212666)
0.725
4
UniProt:Q9BYM8 RBCK1
1
RBCK1 [cytosol]
(R-HSA-976018)
0.725
6
UniProt:Q15628 TRADD
1
TRADD [cytosol]
(R-HSA-66376)
0.725
7
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.669
3
UniProt:Q96EP0 RNF31
1
RNF31 [cytosol]
(R-HSA-5212660)
0.643
3
UniProt:Q8UYL3 Q8UYL3
0.641
3
UniProt:P31949 S100A11
2
S100A11 [extracellular region]
(R-HSA-6804808)
S100A11 [secretory granule lumen]
(R-HSA-6804784)
0.618
4
UniProt:P80511 S100A12
2
S100A12 [secretory granule lumen]
(R-HSA-6804789)
S100A12 [extracellular region]
(R-HSA-879450)
0.618
4
UniProt:P20333 TNFRSF1B
3
TNFRSF1B(27-?) [plasma membrane]
(R-HSA-6785037)
TNFRSF1B [specific granule membrane]
(R-HSA-6806149)
TNFRSF1B [plasma membrane]
(R-HSA-5661484)
0.609
2
UniProt:Q16623 STX1A
5
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.601
4
UniProt:P25118
1
TNFRSF1A(30-45) [plasma membrane]
(R-MMU-5675738)
0.576
4
UniProt:Q60855
14
K48polyUb-RIPK1 [cytosol]
(R-MMU-6783308)
PolyUb-RIPK1 [cytosol]
(R-MMU-6783197)
RIPK1 [cytosol]
(R-MMU-168651)
K63polyUb-RIPK1 [cytosol]
(R-MMU-937021)
phospho-p-S166-RIPK1 [cytosol]
(R-MMU-5218872)
phospho-p-S357-RIPK1 [cytosol]
(R-MMU-9819116)
phospho-p-S320-RIPK1 [cytosol]
(R-MMU-9815498)
phospho-K63,M1polyUb, p-T189-RIPK1 [cytosol]
(R-MMU-9817377)
polyUb-K377,K604,K634-RIPK1 [cytosol]
(R-MMU-9818391)
RIPK1(325-671) [cytosol]
(R-MMU-5212671)
RIPK1(1-324) [cytosol]
(R-MMU-5212664)
K63,M1polyUb-RIPK1 [cytosol]
(R-MMU-9793681)
phospho-K63,Met1polyUb-p-S25-RIPK1 [cytosol]
(R-MMU-9818793)
K48polyUb-K571,K604,K627-RIPK1 [cytosol]
(R-MMU-9796639)
0.576
4
UniProt:Q9DHW0 Q9DHW0
0.558
2
UniProt:Q99584 S10AD
0.558
3
calcium(2+) [ChEBI:29108]
20
Ca2+ [platelet dense granule lumen]
(R-ALL-114582)
Ca2+ [endosome membrane]
(R-ALL-5210949)
Ca2+ [sarcoplasmic reticulum lumen]
(R-ALL-2855229)
Ca2+ [mitochondrial intermembrane space]
(R-ALL-8949232)
Ca2+ [endocytic vesicle lumen]
(R-ALL-8851519)
Ca2+ [lysosomal lumen]
(R-ALL-1606834)
Ca2+ [endoplasmic reticulum-Golgi intermediate compartment]
(R-ALL-9706979)
Ca2+ [Golgi lumen]
(R-ALL-167012)
Ca2+ [platelet dense tubular network lumen]
(R-ALL-139827)
Ca2+ [platelet dense tubular network membrane]
(R-ALL-141090)
Ca2+ [plasma membrane]
(R-ALL-140648)
Ca2+ [secretory granule lumen]
(R-ALL-216801)
Ca2+ [nuclear envelope]
(R-ALL-2318767)
Ca2+ [nucleoplasm]
(R-ALL-29496)
Ca2+ [mitochondrial matrix]
(R-ALL-8949220)
Ca2+ [mitochondrial inner membrane]
(R-ALL-1524102)
Ca2+ [endoplasmic reticulum membrane]
(R-ALL-1500625)
Ca2+ [cytosol]
(R-ALL-74016)
Ca2+ [extracellular region]
(R-ALL-74112)
Ca2+ [endoplasmic reticulum lumen]
(R-ALL-111875)
0.558
5
UniProt:O75459 PAGE1
0.556
3
UniProt:Q92482 AQP3
1
AQP3 [plasma membrane]
(R-HSA-431723)
0.556
3
UniProt:Q9H7M9 VISTA
0.556
3
UniProt:Q96RD7 PANX1
1
PANX1 [plasma membrane]
(R-HSA-375344)
0.556
3
UniProt:Q6ZMZ0 RNF19B
1
RNF19B [cytosol]
(R-HSA-975969)
0.556
3
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
3
UniProt:Q16585 SGCB
0.556
3
UniProt:Q8N386 LRC25
0.556
3
UniProt:Q15849 SLC14A2
1
SLC14A2 [plasma membrane]
(R-HSA-444115)
0.556
3
UniProt:Q5JX71 F209A
0.556
3
UniProt:O43300 LRRTM2
1
LRRTM2 [plasma membrane]
(R-HSA-6797966)
0.556
3
UniProt:P00387 CYB5R3
3
MyrG-CYB5R3(2-301) [mitochondrial outer membrane]
(R-HSA-198771)
CYB5R3(27-301) [extracellular region]
(R-HSA-6806205)
CYB5R3(27-301) [azurophil granule lumen]
(R-HSA-6799217)
0.556
3
UniProt:Q8TBE3 FNDC9
0.556
3
UniProt:Q6NSX1 CCD70
0.556
3
UniProt:Q53GL0 PKHO1
0.556
3
UniProt:Q6PEW1 ZCH12
0.556
3
UniProt:Q8WWF3 SSMM1
0.556
3
UniProt:Q8N6L0 KASH5
0.556
3
UniProt:Q8N4L2 PP4P2
0.556
3
UniProt:Q6UXG8-3 Q6UXG83
0.556
3
UniProt:Q8IYJ2-2 C10ORF67
0.556
3
UniProt:Q8WV48 CC107
0.556
3
UniProt:O95471 CLDN7
2
CLDN7 [cell junction]
(R-HSA-421241)
CLDN7 [plasma membrane]
(R-HSA-420004)
0.556
3
UniProt:P27105 STOM
4
STOM [tertiary granule membrane]
(R-HSA-6800960)
STOM [plasma membrane]
(R-HSA-6806258)
STOM [azurophil granule membrane]
(R-HSA-6800997)
STOM [specific granule membrane]
(R-HSA-6799569)
0.556
3
UniProt:O15393-2 TMPRSS2
0.556
3
UniProt:O14863 ZNT4
0.556
3
UniProt:Q9BXK5 B2L13
0.556
3
UniProt:Q8IUN9 CLEC10A
1
CLEC10A [plasma membrane]
(R-HSA-1472863)
0.556
3
UniProt:Q9HC36 MRM3
1
RNMTL1 [mitochondrial matrix]
(R-HSA-6793067)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:O15552 FFAR2
1
FFAR2 [plasma membrane]
(R-HSA-443944)
0.556
3
UniProt:O75051 PLXNA2
2
PLXNA2 [plasma membrane]
(R-HSA-396934)
p-Y-PLXNA2 [plasma membrane]
(R-HSA-419607)
0.527
2
UniProt:O75976 CPD
3
CPD [Golgi membrane]
(R-HSA-432675)
CPD [cytoplasmic vesicle membrane]
(R-HSA-432671)
CPD [plasma membrane]
(R-HSA-9715182)
0.527
2
UniProt:P48723 HSPA13
2
HSPA13 [cytosol]
(R-HSA-5251981)
HSPA13 [nucleoplasm]
(R-HSA-5252009)
0.527
2
UniProt:Q15382 RHEB
2
RHEB [endosome membrane]
(R-HSA-5656350)
RHEB [lysosomal membrane]
(R-HSA-165190)
0.527
2
UniProt:Q6P9B9 INTS5
1
INTS5 [nucleoplasm]
(R-HSA-6807418)
0.527
2
UniProt:P04632 CAPNS1
2
CAPNS1 [cytosol]
(R-HSA-3288229)
CAPNS1 [plasma membrane]
(R-HSA-3828034)
0.527
2
UniProt:Q8N442 GUF1
0.527
2
UniProt:P41273 TNFSF9
1
TNFSF9 [plasma membrane]
(R-HSA-5667144)
0.527
2
UniProt:Q8TD22 SFXN5
0.527
2
UniProt:O43286 B4GALT5
1
B4GALT5 [Golgi membrane]
(R-HSA-1015832)
0.527
2
UniProt:Q14118 DAG1
10
GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen]
(R-HSA-8931659)
GlcNAc,1,2-Man-DAG1 [Golgi lumen]
(R-HSA-5617087)
Man-DAG1 [Golgi lumen]
(R-HSA-8931888)
GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]
(R-HSA-8931656)
GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]
(R-HSA-8931673)
Man-DAG1 [endoplasmic reticulum lumen]
(R-HSA-5615647)
DAG1(30-653) [endoplasmic reticulum lumen]
(R-HSA-8931890)
DAG1(30-653) [cytosol]
(R-HSA-5615641)
DAG1(30-653) [extracellular region]
(R-HSA-2328152)
DAG1(654-895) [plasma membrane]
(R-HSA-2328154)
0.527
2
UniProt:P21580 TNFAIP3
1
TNFAIP3 [cytosol]
(R-HSA-688989)
0.527
2
UniProt:O88351
2
phospho-p-S177,S181-IKBKB [cytosol]
(R-MMU-202506)
IKBKB [cytosol]
(R-MMU-168114)
0.499
3
UniProt:Q60769
1
TNFAIP3 [cytosol]
(R-MMU-688989)
0.499
2
UniProt:O89110
6
Casp8 [cytosol]
(R-MMU-3465404)
Casp8 [mitochondrial outer membrane]
(R-MMU-351869)
Casp8 [mitochondrial outer membrane]
(R-MMU-351828)
Casp8 [cytosol]
(R-MMU-76158)
Casp8 [cytosol]
(R-MMU-75975)
Casp8 [cytosol]
(R-MMU-57031)
0.499
2
UniProt:Q3U0V2
1
TRADD [cytosol]
(R-MMU-66376)
0.499
2
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