Reactome | TTR [extracellular region]

TTR [extracellular region]

Stable Identifier

R-HSA-976883

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Transthyretin, TTHY_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of the neuronal system (Homo sapiens)
  - Diseases associated with visual transduction (Homo sapiens)
    - Retinoid cycle disease events (Homo sapiens)
      - Defective visual phototransduction due to STRA6 loss of function (Homo sapiens)
        
        Defective STRA6 does not transport atROL (Homo sapiens)
        
        TTR:RBP4:atROL:STRA6 mutants [plasma membrane] (Homo sapiens)
        
        TTR:RBP4:atROL [extracellular region] (Homo sapiens)
        
        TTR tetramer [extracellular region] (Homo sapiens)
        
        TTR [extracellular region] (Homo sapiens)

Extracellular matrix organization (Homo sapiens)

- Non-integrin membrane-ECM interactions (Homo sapiens)
  - HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Homo sapiens)
    - FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
      - Transthyretin tetramer [extracellular region] (Homo sapiens)
        
        TTR [extracellular region] (Homo sapiens)
    - HSPG2:FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
      - FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
        
        Transthyretin tetramer [extracellular region] (Homo sapiens)
        
        TTR [extracellular region] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Amyloid fiber formation (Homo sapiens)
  - Amyloid fibrils have additional components (Homo sapiens)
    - Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
      - Systemic amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Transthyretin fibril [extracellular region] (Homo sapiens)
        
        TTR [extracellular region] (Homo sapiens)
    - Amyloid fibrils [plasma membrane] (Homo sapiens)
      - Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Systemic amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Transthyretin fibril [extracellular region] (Homo sapiens)
        
        TTR [extracellular region] (Homo sapiens)
  - Amyloid precursor proteins form ordered fibrils (Homo sapiens)
    - Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
      - Systemic amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Transthyretin fibril [extracellular region] (Homo sapiens)
        
        TTR [extracellular region] (Homo sapiens)
    - Amyloid fibril monomers [extracellular region] (Homo sapiens)
      - Systemic amyloid fibril monomers [extracellular region] (Homo sapiens)
        
        TTR [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02766 TTR

Gene Names

TTR, PALB

Chain

signal peptide:1-20, chain:21-147

Reference Genes

BioGPS Gene:7276 TTR

COSMIC (genes):TTR TTR

CTD Gene:7276 TTR

dbSNP Gene:7276 TTR

ENSEMBL:ENSG00000118271 TTR

HGNC:12405 TTR

KEGG:hsa:7276 TTR

Monarch:7276 TTR

NCBI Gene:7276 TTR

OMIM:176300 TTR

UCSC:P02766 TTR

Reference Transcript

RefSeq:NM_000371.3 TTR

Other Identifiers

11754285_a_at

16851786

209660_PM_at

209660_at

32252_at

3783577

3783578

3783579

3783580

3783581

3783582

3783583

3783584

3783587

3783588

3783589

48169_at

56995_at

7276

8020795

A_23_P130333

GE80911

GE85857

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0006144

GO:0007165

GO:0035578

GO:0042802

GO:0043226

GO:0048018

GO:0055086

GO:0070062

GO:0070324

GO:0098772

HMNXSV003012754

ILMN_2198912

M15517_cds5_at

PH_hs_0019852

PH_hs_0033292

TC18000129.hg

g5533090_3p_at

Participates

as a component of

as a member of

as a repeated unit of

Transthyretin fibril [extracellular region] (Homo sapiens)

Other forms of this molecule

TTR [azurophil granule lumen]

Inferred To

Homologues of TTR [extracellular region] (Caenorhabditis elegans)

Homologues of TTR [extracellular region] (Sus scrofa)

TTR [extracellular region] (Bos taurus)

TTR [extracellular region] (Caenorhabditis elegans)

TTR [extracellular region] (Canis familiaris)

TTR [extracellular region] (Dictyostelium discoideum)

TTR [extracellular region] (Drosophila melanogaster)

TTR [extracellular region] (Gallus gallus)

TTR [extracellular region] (Mus musculus)

TTR [extracellular region] (Rattus norvegicus)

TTR [extracellular region] (Schizosaccharomyces pombe)

TTR [extracellular region] (Sus scrofa)

TTR [extracellular region] (Xenopus tropicalis)

Cross References

ZINC - World Drugs

TTHY_HUMAN

Guide to Pharmacology - Targets

2851

OpenTargets

ENSG00000118271

ENSEMBL

ENSP00000237014, ENST00000649620, ENST00000237014, ENSP00000497927

ZINC - FDA approved

TTHY_HUMAN

ZINC - Substances

TTHY_HUMAN

ZINC - Biogenic

TTHY_HUMAN

ZINC target

P02766

PRO

P02766

GlyGen

P02766

PDB

8VE3, 5CLX, 1BM7, 4ABW, 6SUG, 5AKS, 4N87, 3W3B, 3GS0, 2F8I, 5LLL, 5U4A, 5H0X, 3IMU, 5CN3, 2M5N, 2F7I, 8JOK, 8W46, 6E78, 3GRB, 1DVX, 1SOK, 4IKI, 8W2W, 4HJS, 4QRF, 5CLZ, 4FI6, 3BSZ, 2QGC, 8PKG, 8VE4, 7Q9O, 3CXF, 4PM1, 5U4C, 3DO4, 4FI7, 5H0W, 3IMV, 8I00, 3NEX, 8T5X, 5EZP, 6E6Z, 3GS4, 3A4F, 4WO0, 1DVU, 4IKJ, 8WGS, 5L4M, 3HJ0, 3IPB, 2TRH, 5CLY, 4ABU, 3I9P, 5TZL, 4HIS, 4TQ8, 1BZD, 3KGU, 1TTR, 1THA, 5NFW, 3IMT, 4L1S, 2WQA, 6FFT, 7OB4, 3NES, 5K1N, 8W48, 1TTB, 1DVZ, 6FWD, 4TNE, 6IMX, 5DWP, 6XTK, 5H0V, 2QGD, 4ABV, 8VE6, 6SUH, 5AKT, 8JQW, 1Y1D, 5CR1, 3IPE, 6R66, 3CFM, 2G9K, 3D7P, 8W45, 4N86, 1TTA, 6FXU, 8W1N, 1DVY, 1BMZ, 3TCT, 7ACU, 4L1T, 4Y9E, 4TLS, 7EJR, 3GPS, 4MRB, 4IKL, 6E71, 3I9A, 8C86, 1E3F, 4PWG, 5U49, 5U4D, 7QC5, 5DEJ, 2G4G, 3P3U, 3BT0, 6SDZ, 3DGD, 8WGT, 6TXV, 7YBR, 4TNF, 3FC8, 4D7B, 3DID, 4WNS, 8II2, 4MRC, 1BZ8, 5FO2, 7THA, 6E70, 4TLK, 6EOY, 4PWH, 5U48, 5U4G, 4Y9F, 3GLZ, 2GAB, 4PVL, 3CFN, 6E73, 3OZK, 3ESP, 2H4E, 5L4F, 3U2I, 4TQP, 1DVQ, 2QGB, 5AKV, 4N85, 2QEL, 3P3R, 5U4B, 4FI8, 6R68, 3FCB, 3B56, 5H0Z, 4PWE, 1FHN, 6TI9, 2NBP, 3P3S, 8HEJ, 1DVT, 4IKK, 3ESN, 2G3Z, 4HJT, 1TT6, 3SSG, 4QXV, 5JID, 3I9I, 3DK0, 5CM1, 8C85, 7DT8, 4PWF, 5H0Y, 6U0Q, 5U4E, 1TLM, 6GRP, 2NBO, 3NEO, 1GKO, 3P3T, 3ESO, 5IHH, 1DVS, 4HJU, 4ANK, 2G3X, 6TXW, 1E5A, 7ERK, 7EJQ, 4IIZ, 8II1, 4PWJ, 5A6I, 7DT6, 1SOQ, 6EP1, 4Y9G, 3CN2, 3A4E, 1G1O, 3CFT, 8E7D, 6E74, 1X7S, 8PMA, 2B77, 2B16, 2ROX, 8II4, 2TRY, 3DK2, 3NEE, 8IG1, 4PWK, 7ERH, 3NG5, 5JIM, 8AWW, 3TFB, 1III, 7DT3, 8I0O, 4QYA, 1IJN, 3CN3, 5L4J, 3IMW, 4YDM, 5FW7, 8PMO, 2B15, 2PAB, 4TLU, 3DJR, 8JNU, 1TZ8, 4ABQ, 4DES, 4TQH, 3CN0, 1QAB, 2FBR, 8II3, 7Z60, 3CBR, 8G9R, 1TYR, 2G4E, 5U4F, 8HY4, 5TTR, 5NFE, 4PVM, 3CFQ, 1X7T, 6E72, 5K1J, 4DEU, 8WGU, 4TNG, 3OZL, 4TLT, 7ERJ, 6GR7, 4DEW, 8E7J, 3GRG, 7Y6J, 2G5U, 4PWI, 7DT5, 3A4D, 5E23, 3CN1, 3D2T, 4PVN, 4DER, 5N7C, 6E75, 5AYT, 1U21, 1IIK, 2ROY, 3U2J, 5LLV, 6R6I, 8VE1, 1RLB, 8AWI, 5E4A, 5JIQ, 7YCQ, 8W42, 4TL5, 7W9Q, 4TM9, 3GS7, 8E7H, 1ETA, 4Y9C, 1E4H, 6KGB, 5BOJ, 6E76, 4PME, 1ZCR, 8PM8, 1Z7J, 8TDO, 5EN3, 1F86, 3KGS, 4TQI, 7Q9L, 5AL0, 4ACT, 1F41, 4AC4, 5N5Q, 6R67, 1FH2, 8PKF, 7W9R, 2QGE, 1ICT, 3KGT, 1BZE, 8VE5, 7Y1I, 8E7I, 5E4O, 4TKW, 4WNJ, 2FLM, 8PM9, 7WL6, 8W47, 1TTC, 4I89, 6IMY, 5N62, 4PMF, 8PKE, 6FZL, 6D0W, 7ERI, 5CNH, 4MAS, 3IMR, 4KY2, 8W43, 3M1O, 1ETB, 8ADE, 3CN4, 5L4I, 6E77, 5FW6, 8E7E, 2B14, 8VE2, 3DJS, 5AL8, 7Q9N, 6TJN, 4DET, 4AC2, 4IK6, 4I85, 4TL4, 7Q3I, 3IMS, 2NOY, 8W44, 5OQ0, 3DJT, 1TSH, 1THC, 2B9A, 4Y9B, 4YDN, 8GBR, 5FW8, 3DJZ, 5HJG, 8VE0, 1QWH, 8TDN, 4HIQ, 4I87, 1ZD6, 4IK7

ZINC - Metabolites

TTHY_HUMAN

HPA

ENSG00000118271-TTR

Pharos - Targets

P02766

Orphanet

TTR

ZINC - Predictions - Purchasable

TTHY_HUMAN

HMDB Protein

HMDBP01831

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18848 ATF4	2	ATF4 [cytosol] (R-HSA-381084) ATF4 [nucleoplasm] (R-HSA-381016)	0.668	3
UniProt:P02753 RBP4	3	RBP4(19-201) [extracellular region] (R-HSA-2453675) RBP4 I41N [extracellular region] (R-HSA-2471954) RBP4 G75D [extracellular region] (R-HSA-2471928)	0.646	4
UniProt:P25713 MT3	1	MT3 [cytosol] (R-HSA-5660396)	0.593	3
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.558	2
UniProt:Q8N163 CCAR2	2	DBC1 [nucleoplasm] (R-HSA-3371479) p-T454-DBC1 [nucleoplasm] (R-HSA-3371569)	0.556	3
UniProt:Q9Y2D1 ATF5	3	ATF5 [mitochondrial matrix] (R-HSA-9841250) ATF5 [cytosol] (R-HSA-9841253) ATF5 [nucleoplasm] (R-HSA-9653719)	0.556	3
UniProt:Q8N3R9 MPP5	2	MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9689606) MPP5 [plasma membrane] (R-HSA-419969)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q13569 TDG	3	TDG [nucleoplasm] (R-HSA-65812) monoSUMO1-K330-TDG [nucleoplasm] (R-HSA-4551718) polySUMO2,3-K330-TDG [nucleoplasm] (R-HSA-4551628)	0.556	3
UniProt:Q6NXG1 ESRP1	3	ESRP1(1-606)-RAF1(227-648) fusion [cytosol] (R-HSA-6802312) ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol] (R-HSA-6802523) ESRP1 [nucleoplasm] (R-HSA-6803472)	0.556	3
UniProt:Q06136 KDSR	1	KDSR [endoplasmic reticulum membrane] (R-HSA-428134)	0.556	3
UniProt:Q8NBJ7 SUMF2	1	SUMF2 [endoplasmic reticulum lumen] (R-HSA-1614305)	0.556	3
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.553	2
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.553	2
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.553	2
UniProt:P61916 NPC2	3	NPC2 [lysosomal lumen] (R-HSA-8876488) NPC2 [extracellular region] (R-HSA-6806224) NPC2 [azurophil granule lumen] (R-HSA-6799163)	0.527	2

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