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NPPA(1-151) [extracellular region]
Stable Identifier
R-HSA-976950
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
NPPA, Atrial natriuretic factor, ANF
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
YAP1- and WWTR1 (TAZ)-stimulated gene expression (Homo sapiens)
Expression of NPPA (ANF) (Homo sapiens)
NPPA(1-151) [extracellular region] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Physiological factors (Homo sapiens)
CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Homo sapiens)
NPPA(1-151) [extracellular region] (Homo sapiens)
Expression of NPPA (ANF) (Homo sapiens)
NPPA(1-151) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01160 NPPA
Gene Names
NPPA, ANP, PND
Chain
signal peptide:1-25, chain:26-151, peptide:26-55, peptide:56-92, propeptide:93-103, peptide:104-123, peptide:119-151, peptide:120-151, peptide:121-145, peptide:124-151, peptide:127-151, peptide:127-150, peptide:128-151, peptide:128-150, peptide:128-148
Reference Genes
BioGPS Gene:4878 NPPA
COSMIC (genes):NPPA NPPA
CTD Gene:4878 NPPA
dbSNP Gene:4878 NPPA
ENSEMBL:ENSG00000175206 NPPA
ENSEMBL_homo_sapiens_GENE:ENSG00000175206.11 NPPA
HGNC:7939 NPPA
KEGG Gene (Homo sapiens):4878 NPPA
Monarch:4878 NPPA
NCBI Gene:4878 NPPA
OMIM:108780 NPPA
UCSC:P01160 NPPA
Reference Transcript
RefSeq:NM_006172.3 NPPA
Other Identifiers
11757468_a_at
16681799
209957_PM_s_at
209957_s_at
2396850
2396853
2396854
2396855
2396856
36663_at
4878
73106_s_at
7912515
A_23_P74059
GE80253
GO:0003008
GO:0003012
GO:0003013
GO:0003085
GO:0003161
GO:0003180
GO:0005102
GO:0005179
GO:0005184
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0006182
GO:0006457
GO:0007168
GO:0007218
GO:0007565
GO:0008217
GO:0010460
GO:0014898
GO:0019934
GO:0022414
GO:0023052
GO:0030312
GO:0031012
GO:0032991
GO:0035994
GO:0036211
GO:0036376
GO:0042311
GO:0042995
GO:0043204
GO:0043508
GO:0045776
GO:0048018
GO:0048856
GO:0051427
GO:0055085
GO:0055086
GO:0060372
GO:0060452
GO:0062023
GO:0071855
GO:0097746
GO:0098772
GO:1901135
GO:1901841
GO:1902261
GO:1902514
GO:1903766
HMNXSV003011416
ILMN_1750386
M54951_at
PH_hs_0004354
PH_hs_0031323
TC01002204.hg
g180181_3p_s_at
Participates
as an input of
CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Homo sapiens)
as an output of
Expression of NPPA (ANF) (Homo sapiens)
Other forms of this molecule
NPPA(124-151) [extracellular region]
NPPA(1-25) [extracellular region]
NPPA(56-123) [extracellular region]
NPPA(26-55) [extracellular region]
Inferred To
Nppa [extracellular region]
(Mus musculus)
Nppa [extracellular region]
(Rattus norvegicus)
NPPA [extracellular region]
(Bos taurus)
NPPA [extracellular region]
(Canis familiaris)
NPPA [extracellular region]
(Sus scrofa)
nppa [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_006163.1
OpenTargets
ENSG00000175206
GeneCards
P01160
ZINC - Substances
ANF_HUMAN
HPA
ENSG00000175206-NPPA
Ensembl
ENST00000376480
,
ENSG00000175206
,
ENSP00000365663
ZINC target
P01160
PRO
P01160
Pharos - Targets
P01160
ZINC - Predictions - Purchasable
ANF_HUMAN
Orphanet
18488
PDB
7BRH
,
7BRK
,
1ANP
,
1YK0
,
7BRJ
,
3N57
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P43365 MAGAC
0.718
6
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
UniProt:O75031 HSF2B
0.556
3
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:O75342 ALOX12B
1
ALOX12B [cytosol]
(R-HSA-2142832)
0.527
2
UniProt:O60911 CTSV
4
CTSL2 [lysosomal lumen]
(R-HSA-1181232)
CTSL2 [early endosome lumen]
(R-HSA-4127471)
CTSL2 [extracellular region]
(R-HSA-2228669)
CTSL2 [endolysosome lumen]
(R-HSA-4127477)
0.527
2
UniProt:A8K2U0 A2ML1
0.527
2
UniProt:P07476 IVL
2
IVL [cornified envelope]
(R-HSA-8847720)
IVL [cytosol]
(R-HSA-6810837)
0.527
2
UniProt:Q9UI42 CBPA4
0.527
2
UniProt:Q8NEX9 SDR9C7
1
SDR9C7 [endoplasmic reticulum membrane]
(R-HSA-4084690)
0.527
2
UniProt:P14923 JUP
6
JUP [cytosol]
(R-HSA-201598)
JUP [cornified envelope]
(R-HSA-8847739)
JUP [specific granule lumen]
(R-HSA-6799534)
JUP [extracellular region]
(R-HSA-6806309)
JUP [ficolin-1-rich granule lumen]
(R-HSA-6801028)
JUP [plasma membrane]
(R-HSA-437260)
0.527
2
UniProt:P48594 SPB4
0.527
2
UniProt:Q6GTS8 PM20D1
1
PM20D1 [extracellular region]
(R-HSA-9673052)
0.527
2
UniProt:Q10713 PMPCA
1
PMPCA [mitochondrial matrix]
(R-HSA-1299450)
0.527
2
UniProt:Q5TEU4 NDUFAF5
1
NDUFAF5 [mitochondrial inner membrane]
(R-HSA-5689127)
0.527
2
UniProt:Q9NRG4 SMYD2
1
SMYD2 [nucleoplasm]
(R-HSA-3222233)
0.527
2
UniProt:P22735 TGM1
3
TGM1 [cytosol]
(R-HSA-6813756)
TGM1 [cornified envelope]
(R-HSA-8847706)
TGM1 [plasma membrane]
(R-HSA-6813757)
0.527
2
UniProt:P29508 SERPINB3
2
SERPINB3 [extracellular region]
(R-HSA-6806189)
SERPINB3 [azurophil granule lumen]
(R-HSA-6799340)
0.527
2
UniProt:P53582 METAP1
1
METAP1 [cytosol]
(R-HSA-2534097)
0.527
2
UniProt:Q15126 PMVK
1
PMVK [cytosol]
(R-HSA-191348)
0.527
2
UniProt:O75439 PMPCB
1
PMPCB [mitochondrial matrix]
(R-HSA-1299434)
0.527
2
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