Reactome | ISCU [cytosol]

ISCU [cytosol]

Stable Identifier

R-HSA-9771680

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser for interactor UniProt:Q13422 IKZF1

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        Early SARS-CoV-2 Infection Events (Homo sapiens)
        
        Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
        
        Maturation of replicase proteins (Homo sapiens)
        
        nsp12 acquires Fe-S cluster cofactors (Homo sapiens)
        
        ISCU [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H1K1 ISCU

Gene Names

ISCU, NIFUN

Chain

transit peptide:1-34, chain:35-167

Reference Genes

BioGPS Gene:23479 ISCU

COSMIC (genes):ISCU ISCU

CTD Gene:23479 ISCU

dbSNP Gene:23479 ISCU

ENSEMBL:ENSG00000136003 ISCU

ENSEMBL_homo_sapiens_GENE:ENSG00000136003.16 ISCU

HGNC:29882 ISCU

KEGG Gene (Homo sapiens):23479 ISCU

Monarch:23479 ISCU

NCBI Gene:23479 ISCU

OMIM:611911 ISCU

UCSC:Q9H1K1 ISCU

Reference Transcript

Other Identifiers

11727539_x_at

11757291_s_at

209075_PM_s_at

209075_s_at

23479

3430778

3430783

3430784

3430786

3430787

3430789

3430791

3430797

3430798

39165_at

7958414

A_23_P340158

GO:0005506

GO:0005515

GO:0005634

GO:0005737

GO:0005739

GO:0005759

GO:0005829

GO:0006091

GO:0006790

GO:0006879

GO:0008198

GO:0008270

GO:0016226

GO:0042803

GO:0043226

GO:0044571

GO:0044572

GO:0046872

GO:0051536

GO:0051537

GO:0055065

GO:0055085

GO:0060090

GO:0099128

GO:1902958

GO:1904234

GO:1904439

GO:1990229

HMNXSV003009906

HMNXSV003048952

ILMN_1735432

ILMN_2409062

PH_hs_0016913

TC12000836.hg

U47101_at

g11545706_3p_a_at

Participates

as an output of

nsp12 acquires Fe-S cluster cofactors (Homo sapiens)

as a component of

ISCU:Fe4S4 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_998760.1, NP_055116.1, NP_001306971.1

OpenTargets

ENSG00000136003

HPA

ENSG00000136003-ISCU

GeneCards

Q9H1K1

Ensembl

ENSG00000136003, ENST00000392807, ENSP00000376554, ENSP00000310623, ENST00000311893

PRO

Q9H1K1

Pharos - Targets

Q9H1K1

Orphanet

17732

PDB

6W1D, 7RTK, 6WI2, 6WIH, 5WKP, 5KZ5, 5WLW, 6NZU, 6UXE

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P37198 NUP62	2	NUP62 [cytosol] (R-HSA-9634226) NUP62 [nuclear envelope] (R-HSA-157713)	0.718	6
UniProt:Q9HD34 LYRM4	1	LYRM4 [mitochondrial matrix] (R-HSA-1362392)	0.669	7
UniProt:P00492 HPRT1	4	HPRT1 [cytosol] (R-HSA-56639) HPRT1 D194N [cytosol] (R-HSA-9734269) HPRT1 G70E [cytosol] (R-HSA-9734286) HPRT1 G140D [cytosol] (R-HSA-9734264)	0.666	4
UniProt:P21912 SDHB	2	SDHB [mitochondrial matrix] (R-HSA-9854983) SDHB [mitochondrial inner membrane] (R-HSA-70985)	0.662	8
UniProt:Q8IWL3 HSCB	5	HSCB [mitochondrial matrix] (R-HSA-1299438) HSCB(1-30) [mitochondrial matrix] (R-HSA-8986120) HSCB(1-235) [mitochondrial inner membrane] (R-HSA-1299443) HSCB [mitochondrial inner membrane] (R-HSA-1299447) HSCB(1-235) [mitochondrial intermembrane space] (R-HSA-1299456)	0.643	10
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.643	3
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.589	2
UniProt:acpP A0A437HBF4			0.57	4
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.564	3
UniProt:Q6RW13 AGTRAP	2	AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol] (R-HSA-6802511) AGTRAP(1-159)-BRAF(288-545) fusion [cytosol] (R-HSA-6802262)	0.556	3
UniProt:Q7Z6G3-2 NECAB2			0.556	3
UniProt:Q8NA61-2 CBY2			0.556	3
UniProt:Q9UJV3-2 MID2			0.556	3
UniProt:Q8N9N5 BANP	1	BANP [nucleoplasm] (R-HSA-3221973)	0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:P0C7W6 CC172			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
IntAct:EBI-16435328 CCSB ORF ID			0.556	3
UniProt:Q8IZU0 FAM9B			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:Q13422 IKZF1			0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P38646 HSPA9	6	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993)	0.499	3
UniProt:A6NFY7 SDHAF1	1	SDHAF1 [mitochondrial matrix] (R-HSA-9854988)	0.462	2
UniProt:Q5U5X0 LYRM7	1	LYRM7 [mitochondrial matrix] (R-HSA-9866252)	0.462	2
UniProt:P47985 UQCRFS1	3	UQCRFS1(1-274) [mitochondrial inner membrane] (R-HSA-9906005) UQCRFS1(1-274) [mitochondrial matrix] (R-HSA-9906006) UQCRFS1(79-274) [mitochondrial inner membrane] (R-HSA-164278)	0.462	4

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