Serine metabolism

Stable Identifier
R-HSA-977347
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Serine metabolism
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L-Serine is needed in human brain in large amounts as precursor to important biomolecules such as nucleotides, phospholipids and the neurotransmitters glycine and D-serine. The pathway for its synthesis starts with 3-phosphoglycerate and it later needs glutamate as an amination agent. Deficiencies in the participating enzymes lead to severe neurological symptoms that are treatable with serine if treatment starts early (de Koning & Klomp 2004).
Literature References
PubMed ID Title Journal Year
15021249 Serine-deficiency syndromes

Klomp, LW, de Koning, TJ

Curr Opin Neurol 2004
Participants
Events
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Event Information
Go Biological Process
L-serine metabolic process (0006563)
Orthologous Events
Serine metabolism (Bos taurus)
Serine metabolism (Caenorhabditis elegans)
Serine metabolism (Canis familiaris)
Serine metabolism (Danio rerio)
Serine metabolism (Dictyostelium discoideum)
Serine metabolism (Drosophila melanogaster)
Serine metabolism (Gallus gallus)
Serine metabolism (Mus musculus)
Serine metabolism (Rattus norvegicus)
Serine metabolism (Saccharomyces cerevisiae)
Serine metabolism (Schizosaccharomyces pombe)
Serine metabolism (Sus scrofa)
Serine metabolism (Xenopus tropicalis)
Authored
Stephan, R  (2010-10-16)
Reviewed
Hill, DP  (2025-02-25)
D'Eustachio, P  (2011-10-26)
Created
Jassal, B  (2010-10-18)
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