PHGHD tetramer dehydrogenates 3PG

Stable Identifier
R-HSA-977348
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
3-phosphoglycerate is dehydrogenated
Locations in the PathwayBrowser
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Serine biosynthesis starts from 3-phosphoglycerate, a glycolysis intermediate. Its dehydrogenation is catalysed by tetrameric phosphoglycerate dehydrogenase (PHGDH). (Tabatabaie et al. 2009).

Literature References
PubMed ID Title Journal Year
19235232 Novel mutations in 3-phosphoglycerate dehydrogenase (PHGDH) are distributed throughout the protein and result in altered enzyme kinetics

Tabatabaie, L, de Koning, TJ, Geboers, AJ, van den Berg, IE, Berger, R, Klomp, LW

Hum Mutat 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphoglycerate dehydrogenase activity of PHGHD tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created