Factor H binds to C3bBb

Stable Identifier
Reaction [binding]
Homo sapiens
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Factor H (CFH) binds to C3bBb, leading to displacement of Bb. Complement factor H-related protein 3 (FHR3) has also been reported to bind C3Bb leading to inhibition of C3Bb C3 convertase activity (Fritsche et al. 2010). CFH also acts as a cofactor for the factor I-mediated proteolytic inactivation of C3b to iC3b.

Literature References
PubMed ID Title Journal Year
301546 Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution

Pangburn, MK, Schreiber, RD, Muller-Eberhard, HJ

J Exp Med 1977
1067618 Control of the amplification convertase of complement by the plasma protein beta1H

Weiler, JM, Daha, MR, Austen, KF, Fearon, DT

Proc Natl Acad Sci U S A 1976
Participant Of
This event is regulated
Orthologous Events
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