Factor H binds to C3bBb

Stable Identifier
R-HSA-977363
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
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Factor H binds to C3bBb
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Factor H (CFH) binds to C3bBb, leading to displacement of Bb. Complement factor H-related protein 3 (FHR3) has also been reported to bind C3Bb leading to inhibition of C3Bb C3 convertase activity (Fritsche et al. 2010). CFH also acts as a cofactor for the factor I-mediated proteolytic inactivation of C3b to iC3b.

Literature References
PubMed ID Title Journal Year
301546 Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution

Pangburn, MK, Schreiber, RD, Muller-Eberhard, HJ

J Exp Med 1977
1067618 Control of the amplification convertase of complement by the plasma protein beta1H

Weiler, JM, Daha, MR, Austen, KF, Fearon, DT

Proc Natl Acad Sci U S A 1976
Participants
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Output
Participant Of
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This event is regulated
Positively by
Orthologous Events
Factor H binds to C3bBb (Canis familiaris)
Factor H binds to C3bBb (Danio rerio)
Authored
Jupe, S  (2010-10-26)
Reviewed
Bradley, DT  (2012-02-13)
Fraczek, LA  (2012-02-13)
Created
Jupe, S  (2010-10-18)
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