Factor H (CFH) binds to C3bBb, leading to displacement of Bb. Complement factor H-related protein 3 (FHR3) has also been reported to bind C3Bb leading to inhibition of C3Bb C3 convertase activity (Fritsche et al. 2010). CFH also acts as a cofactor for the factor I-mediated proteolytic inactivation of C3b to iC3b.
Pangburn, MK, Schreiber, RD, Muller-Eberhard, HJ
Weiler, JM, Daha, MR, Austen, KF, Fearon, DT
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