Reactome | Factor H binds to C3bBb

Factor H binds to C3bBb

Stable Identifier

R-HSA-977363

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Factor H (CFH) binds to C3bBb, leading to displacement of Bb. Complement factor H-related protein 3 (FHR3) has also been reported to bind C3Bb leading to inhibition of C3Bb C3 convertase activity (Fritsche et al. 2010). CFH also acts as a cofactor for the factor I-mediated proteolytic inactivation of C3b to iC3b.

Literature References

PubMed ID	Title	Journal	Year
1067618	Control of the amplification convertase of complement by the plasma protein beta1H Weiler, JM, Fearon, DT, Daha, MR, Austen, KF	Proc Natl Acad Sci U S A	1976
301546	Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution Schreiber, RD, Pangburn, MK, Muller-Eberhard, HJ	J Exp Med	1977