Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CR1 [plasma membrane]
Stable Identifier
R-HSA-977369
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Complement receptor type 1, CR1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P11226 MBL2
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) (Homo sapiens)
CR1 gene expression is stimulated by RUNX1 (Homo sapiens)
CR1 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
CR1 binds C3bBb/C4bC2a (Homo sapiens)
CR1 [plasma membrane] (Homo sapiens)
Factor I cleaves iC3b (Homo sapiens)
CR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17927 CR1
Gene Names
CR1, C3BR
Chain
signal peptide:1-41, chain:42-2039
Reference Genes
BioGPS Gene:1378 CR1
COSMIC (genes):CR1 CR1
CTD Gene:1378 CR1
dbSNP Gene:1378 CR1
ENSEMBL:ENSG00000203710 CR1
HGNC:2334 CR1
KEGG:hsa:1378 CR1
Monarch:1378 CR1
NCBI Gene:1378 CR1
OMIM:120620 CR1
UCSC:P17927 CR1
Reference Transcript
RefSeq:NM_000651.4 CR1
RefSeq:NM_000573.3 CR1
Other Identifiers
11733587_a_at
11747196_s_at
11762183_at
1378
16676819
206244_PM_at
206244_at
208488_PM_s_at
208488_s_at
217484_PM_at
217484_at
217552_3p_x_at
217552_PM_x_at
217552_x_at
2377333
2377334
2377335
2377336
2377342
2377343
2377344
2377345
2377346
2377347
2377350
2377351
2377352
2377353
2377355
2377356
2377357
2377358
2377360
2377361
2377362
2377363
2377365
2377366
2377367
2377369
2377370
2377371
2377372
2377374
2377375
2377376
2377377
2377378
2377379
2377380
2377381
2377382
2377384
2377385
2377386
2377388
2377389
2377390
2377391
2377392
2377393
2377394
2377395
2377396
2377397
2377398
2377402
2377403
2377404
2377405
2377407
2377408
2377409
2377410
2377411
2377412
2377413
2377414
2377417
2377418
2377419
2377420
2377424
2377425
2377426
2377439
2377534
2377545
2377553
2377570
239205_PM_s_at
239205_s_at
244313_PM_at
244313_at
35892_at
35893_s_at
35894_at
54383_g_at
60374_at
7909371
A_23_P256821
A_24_P265523
GE528090
GE62914
GO:0001618
GO:0001851
GO:0001855
GO:0001861
GO:0001970
GO:0001971
GO:0002376
GO:0002430
GO:0002435
GO:0002456
GO:0002638
GO:0004877
GO:0005515
GO:0005615
GO:0005856
GO:0005886
GO:0006957
GO:0006958
GO:0007009
GO:0008284
GO:0009986
GO:0016020
GO:0030667
GO:0032689
GO:0032703
GO:0042130
GO:0043226
GO:0044853
GO:0045087
GO:0045591
GO:0045916
GO:0045957
GO:0045959
GO:0046718
GO:0060089
GO:0061024
GO:0070062
GO:0098542
GO:0101003
GO:1900004
GO:1900005
GO:1900099
GO:1903660
GO:1904669
HMNXSV003009834
Hs.133255.0.A1_3p_at
Hs.193716.2.S1_3p_at
Hs.89688.0.A1_3p_s_at
ILMN_1711611
ILMN_1742601
ILMN_1767193
ILMN_2388112
L17418_cds2_s_at
M31241_s_at
PH_hs_0023850
TC01001738.hg
X05309_at
X14362_at
g10834973_3p_x_at
g10834995_3p_a_at
Participates
as an output of
CR1 gene expression is stimulated by RUNX1 (Homo sapiens)
Factor I cleaves iC3b (Homo sapiens)
as a member of
Secretory granule membrane proteins [plasma membrane] (Homo sapiens)
Ficolin-rich granule membrane proteins [plasma membrane] (Homo sapiens)
CD46, CR1 [plasma membrane] (Homo sapiens)
as a component of
CR1:iC3b [plasma membrane] (Homo sapiens)
CR1:C4bC2a [plasma membrane] (Homo sapiens)
CR1:C3bBb [plasma membrane] (Homo sapiens)
CR1:C3b [plasma membrane] (Homo sapiens)
CR1:C4b [plasma membrane] (Homo sapiens)
as an input of
CR1 binds C3bBb/C4bC2a (Homo sapiens)
Other forms of this molecule
CR1 [secretory granule membrane]
CR1 [ficolin-1-rich granule membrane]
Inferred To
CT26106 [plasma membrane]
(Drosophila melanogaster)
CR1 [plasma membrane]
(Gallus gallus)
CR1 [plasma membrane]
(Sus scrofa)
Cr1l [plasma membrane]
(Rattus norvegicus)
LOC490269 [plasma membrane]
(Canis familiaris)
Cross References
RefSeq
NP_000564.2
,
NP_000642.3
ENSEMBL
ENSP00000383744
,
ENST00000367051
,
ENST00000367053
,
ENSP00000356020
,
ENST00000400960
,
ENSP00000356018
OpenTargets
ENSG00000203710
HPA
ENSG00000203710-CR1
PRO
P17927
Pharos - Targets
P17927
PDB
2MCY
,
1PPQ
,
2Q7Z
,
1GKG
,
2MCZ
,
5FO9
,
1GKN
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
IntAct:EBI-12735745 C3B
0.722
3
UniProt:P48740-2 MASP1
0.623
5
UniProt:P11226 MBL2
1
MBL2 [extracellular region]
(R-HSA-166674)
0.623
8
IntAct:EBI-6264901 C1Q
0.558
6
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text