ZC3H12A (also known as MCPIP, for MCP-1 induced protein) is an endoribonuclease that also functions as a transcription factor. ZC3H12A is induced in human monocytes in response to monocyte chemotactic protein (MCP-1, also known as CCL2 or C-C motif chemokine 2). ZC3H12A is required for MCP-1-induced angiogenesis. In human embryonic kidney cell line HEK293, exogenously expressed human ZC3H12A was shown by chromatin immunoprecipitation (ChIP) to bind to the promoters of CDH19 and CDH12 genes. Treatment of human umbilical vein endothelial cells (HUVECs) with MCP-1 or transfection of HUVECs with a ZC3H12A expression vector leads to upregulation of CDH19 and CDH12 (Niu et al. 2008).