GABA B receptor activation

Stable Identifier
R-HSA-977444
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
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GABA B receptor activation
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Functional GABA B receptors are heteromers of GABA B1 and B2 subunits, complexed with G protein alpha-i, 0, beta, and gamma subunits. They function as metabotropic receptors. When GABA is bound to the B1 sub-unit, the B2 subunit undergoes a conformational change that releases the G alpha-i G0 dimer (which binds and inactivates cytosolic adenylate cyclase) and the G beta G gamma dimer (which activates the GIRK (KIR3) potassium channel) (Pinard et al. 2010).

Literature References
PubMed ID Title Journal Year
20655485 GABAB receptors: physiological functions and mechanisms of diversity

Pinard, A, Seddik, R, Bettler, B

Adv Pharmacol 2010
Participants
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Orthologous Events
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GABA B receptor activation (Xenopus tropicalis)
Authored
Mahajan, SS  (2010-11-09)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2010-10-19)