Reactome | KCNA3 [plasma membrane]

KCNA3 [plasma membrane]

Stable Identifier

R-HSA-977475

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Potassium voltage-gated channel subfamily A member 3, KCNA3_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Potassium Channels (Homo sapiens)
  - Voltage gated Potassium channels (Homo sapiens)
    - Activation of voltage gated Potassium channels (Homo sapiens)
      - Octamer of Voltage gated K+ channels [plasma membrane] (Homo sapiens)
        
        Voltage gated potassium channel subunits Kv1-12 [plasma membrane] (Homo sapiens)
        
        Kv1 subunits of voltage gated potassium channels [plasma membrane] (Homo sapiens)
        
        KCNA3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P22001 KCNA3

Gene Names

KCNA3, HGK5

Chain

chain:1-575

Reference Genes

BioGPS Gene:3738 KCNA3

COSMIC (genes):KCNA3 KCNA3

CTD Gene:3738 KCNA3

dbSNP Gene:3738 KCNA3

ENSEMBL:ENSG00000177272 KCNA3

ENSEMBL_homo_sapiens_GENE:ENSG00000177272.10 KCNA3

HGNC:6221 KCNA3

KEGG Gene (Homo sapiens):3738 KCNA3

Monarch:3738 KCNA3

NCBI Gene:3738 KCNA3

OMIM:176263 KCNA3

UCSC:P22001 KCNA3

Reference Transcript

RefSeq:NM_002232.4 KCNA3

Other Identifiers

11731916_at

11731917_at

16690752

16690754

207237_PM_at

207237_at

2427607

2427609

2427611

2427613

2427614

2427615

2427618

2427620

2427621

2427622

2427623

2427624

2427625

2427626

2427627

32277_at

3738

42233_r_at

7918457

A_23_P201138

A_32_P56320

A_32_P69956

A_33_P3415032

GE58114

GO:0005215

GO:0005216

GO:0005244

GO:0005249

GO:0005251

GO:0005267

GO:0005515

GO:0005886

GO:0006811

GO:0006813

GO:0008076

GO:0015271

GO:0016020

GO:0021554

GO:0022038

GO:0030424

GO:0034220

GO:0034702

GO:0042734

GO:0044305

GO:0045121

GO:0045211

GO:0048856

GO:0051260

GO:0055085

GO:0065003

GO:0071805

GO:0098978

GO:0110165

HMNXSV003004710

HMNXSV003026031

ILMN_1702604

M85217_at

PH_hs_0010140

TC01002976.hg

TC01002977.hg

TC01005698.hg

TC01005699.hg

g4504814_3p_at

p339

Participates

as a member of

Kv1 subunits of voltage gated potassium channels [plasma membrane] (Homo sapiens)

Inferred To

kcna3 [plasma membrane] (Xenopus tropicalis)

Sh [plasma membrane] (Drosophila melanogaster)

Kcna3 [plasma membrane] (Mus musculus)

Kcna3 [plasma membrane] (Rattus norvegicus)

KCNA3 [plasma membrane] (Bos taurus)

KCNA3 [plasma membrane] (Canis familiaris)

KCNA3 [plasma membrane] (Gallus gallus)

KCNA3 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_002223.3

ZINC - World Drugs

KCNA3_HUMAN

Guide to Pharmacology - Targets

540

OpenTargets

ENSG00000177272

ZINC - FDA approved

KCNA3_HUMAN

ZINC - Substances

KCNA3_HUMAN

ZINC target

P22001

ZINC - Biogenic

KCNA3_HUMAN

PRO

P22001

PDB

7SSX, 7SSY, 7EJ1, 7EJ2, 4BGC, 8DFL, 7SSV, 7SSZ

GeneCards

P22001

HPA

ENSG00000177272-KCNA3

Ensembl

ENST00000685980, ENST00000369769, ENSP00000513296, ENSP00000513297, ENSP00000513298, ENST00000697409, ENSG00000177272, ENSP00000513300, ENSP00000358784, ENST00000697412, ENST00000697410

Pharos - Targets

P22001

ZINC - Predictions - Purchasable

KCNA3_HUMAN

HMDB Protein

HMDBP10847

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UPQ8 DOLK	6	DOLK [endoplasmic reticulum membrane] (R-HSA-449274) DOLK M1I [endoplasmic reticulum membrane] (R-HSA-4755593) DOLK H408D [endoplasmic reticulum membrane] (R-HSA-4755548) DOLK C99S [endoplasmic reticulum membrane] (R-HSA-4755602) DOLK W304C [endoplasmic reticulum membrane] (R-HSA-4755557) DOLK Y441S [endoplasmic reticulum membrane] (R-HSA-4755590)	0.718	6