Reactome | CD55 (DAF) promotes C3bBb/C4bC2a dissociation

CD55 (DAF) promotes C3bBb/C4bC2a dissociation

Stable Identifier

R-HSA-977619

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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CD55 (DAF) promotes C3bBb/C4bC2a dissociation

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Decay accelerating factor (DAF, CD55) is a widely distributed membrane protein. It accelerates the dissociation of C3bBb and C4C2a, thereby inhibiting the amplification of complement. DAF can bind C3b and Bb but must bind both for efficient decay acceleration. The regulatory function of DAF is believed to be inhibition of activated C3 convertase enzymes rather than binding of inactive proenzymes (Harris et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
6238120	Inhibition of complement activation on the surface of cells after incorporation of decay-accelerating factor (DAF) into their membranes Kinoshita, T, Medof, ME, Nussenzweig, V	J Exp Med	1984
8786315	Localization of classical and alternative pathway regulatory activity within the decay-accelerating factor Brodbeck, WG, Medof, ME, Mold, C, Sperry, J, Liu, D	J Immunol	1996