Reactome | IDE [endosome lumen]

IDE [endosome lumen]

Stable Identifier

R-HSA-9794504

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome lumen

Synonyms

Insulin-degrading enzyme ecNumber3.4.24.56/ecNumber, IDE_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor recycling (Homo sapiens)
      - Insulin degradation (Homo sapiens)
        
        IDE, CTSD [endosome lumen] (Homo sapiens)
        
        IDE dimer [endosome lumen] (Homo sapiens)
        
        IDE:Zn++ [endosome lumen] (Homo sapiens)
        
        IDE [endosome lumen] (Homo sapiens)
        
        IDE:Zn++ [endosome lumen] (Homo sapiens)
        
        IDE [endosome lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:P14735 IDE

Gene Names

IDE

Chain

chain:1-1019

Reference Genes

COSMIC (genes):IDE IDE

dbSNP Gene:3416 IDE

ENSEMBL:ENSG00000119912 IDE

Participates

as a component of

IDE:Zn++ [endosome lumen] (Homo sapiens)

Other forms of this molecule

IDE [mitochondrial outer membrane]

PolyUb-IDE [mitochondrial outer membrane]

IDE [peroxisomal matrix]

IDE [cytosol]

Inferred To

IDE [endosome lumen] (Bos taurus)

IDE [endosome lumen] (Canis familiaris)

IDE [endosome lumen] (Gallus gallus)

IDE [endosome lumen] (Mus musculus)

IDE [endosome lumen] (Rattus norvegicus)

IDE [endosome lumen] (Sus scrofa)

ide [endosome lumen] (Danio rerio)

ide [endosome lumen] (Xenopus tropicalis)

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.527	2
UniProt:Q96PC5 MIA2	1	MIA2 [endoplasmic reticulum membrane] (R-HSA-9637821)	0.527	2
UniProt:P02686 MBP	1	MBP [cytosol] (R-HSA-9614770)	0.499	2

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