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p-S,T,S558-NFE2L2 [nucleoplasm]
Stable Identifier
R-HSA-9795736
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser for interactor UniProt:Q14145 KEAP1
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
PRKAA2 phosphorylates nuclear NFE2L2 (Homo sapiens)
p-S,T,S558-NFE2L2 [nucleoplasm] (Homo sapiens)
PRKAA2 regulated nuclear export of NFE2L2 (Homo sapiens)
p-S,T,S558-NFE2L2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16236 NFE2L2
Gene Names
NFE2L2, NRF2
Chain
chain:1-605
Reference Genes
BioGPS Gene:4780 NFE2L2
COSMIC (genes):NFE2L2 NFE2L2
CTD Gene:4780 NFE2L2
dbSNP Gene:4780 NFE2L2
ENSEMBL:ENSG00000116044 NFE2L2
ENSEMBL_homo_sapiens_GENE:ENSG00000116044.17 NFE2L2
HGNC:7782 NFE2L2
KEGG Gene (Homo sapiens):4780 NFE2L2
Monarch:4780 NFE2L2
NCBI Gene:4780 NFE2L2
OMIM:600492 NFE2L2
UCSC:Q16236 NFE2L2
Reference Transcript
RefSeq:NM_001145412.3 NFE2L2
RefSeq:NM_001313901.1 NFE2L2
RefSeq:NM_001313900.1 NFE2L2
RefSeq:NM_001145413.3 NFE2L2
RefSeq:NM_006164.4 NFE2L2
Other Identifiers
11739057_a_at
11743380_s_at
1567013_PM_at
1567013_at
16905475
201146_PM_at
201146_at
2588833
2588834
2588835
2588836
2588837
2588838
2588839
2588841
2588843
2588844
2588845
2588846
2588847
2588863
2588864
2588865
2588866
2588867
2588868
2588896
2588909
2588910
2588913
2588915
2588916
2588924
4780
8056977
853_at
A_23_P5761
A_33_P3225600
GE81603
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001221
GO:0001228
GO:0002376
GO:0002931
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005794
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0006351
GO:0006355
GO:0006357
GO:0006575
GO:0006790
GO:0006954
GO:0006979
GO:0009410
GO:0010033
GO:0010468
GO:0010499
GO:0010628
GO:0010667
GO:0010976
GO:0012501
GO:0016567
GO:0019904
GO:0023052
GO:0030154
GO:0030163
GO:0030194
GO:0030968
GO:0031625
GO:0032993
GO:0034599
GO:0034976
GO:0036211
GO:0036499
GO:0042060
GO:0042149
GO:0043161
GO:0043226
GO:0043536
GO:0043565
GO:0045088
GO:0045454
GO:0045766
GO:0045893
GO:0045944
GO:0045995
GO:0046223
GO:0046326
GO:0048856
GO:0048870
GO:0051171
GO:0055085
GO:0061629
GO:0070301
GO:0071280
GO:0071356
GO:0071456
GO:0071466
GO:0071498
GO:0071499
GO:0080090
GO:0090575
GO:0098542
GO:0098754
GO:0140110
GO:0140467
GO:1900038
GO:1900407
GO:1902037
GO:1902176
GO:1903788
GO:1904294
GO:1904385
GO:1904753
GO:2000060
GO:2000121
GO:2000352
GO:2000379
HMNXSV003047979
ILMN_1790909
PH_hs_0009358
S74017_at
TC02004721.hg
TC02005045.hg
g5453775_3p_at
Participates
as an output of
PRKAA2 phosphorylates nuclear NFE2L2 (Homo sapiens)
This entity regulates
Negatively
PRKAA2 regulated nuclear export of NFE2L2
(Homo sapiens)
Other forms of this molecule
p-S40, S344, S347- NFE2L2 [nucleoplasm]
p-S344, S347,T-NFE2L2 [nucleoplasm]
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
ub-NFE2L2 [cytosol]
p-S40-18 AcK-NFE2L2 [nucleoplasm]
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
NFE2L2 [cytosol]
p-S,T-NFE2L2 [cytosol]
p-S40-NFE2L2 [cytosol]
p-S,T-NFE2L2 [nucleoplasm]
p-S40-NFE2L2 [nucleoplasm]
Inferred To
phospho-skn-1 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of p-S,T,S558-NFE2L2 [nucleoplasm]
(Caenorhabditis elegans)
phospho-nfe2l2 [nucleoplasm]
(Xenopus tropicalis)
phospho-NFE2L2 [nucleoplasm]
(Bos taurus)
phospho-NFE2L2 [nucleoplasm]
(Canis familiaris)
phospho-NFE2L2 [nucleoplasm]
(Sus scrofa)
phospho-Nfe2l2 [nucleoplasm]
(Mus musculus)
phospho-Nfe2l2 [nucleoplasm]
(Rattus norvegicus)
phospho-cnc [nucleoplasm]
(Drosophila melanogaster)
phospho-p-S,T,S558-NFE2L2 [nucleoplasm]
(Gallus gallus)
phospho-nfe2l2a [nucleoplasm]
(Danio rerio)
phospho-sknr-1 [nucleoplasm]
(Caenorhabditis elegans)
Modified Residues
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 558
Coordinate
558
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001138885.1
,
NP_001300829.1
,
NP_006155.2
,
NP_001138884.1
,
NP_001300830.1
Guide to Pharmacology - Targets
3057
OpenTargets
ENSG00000116044
ZINC - Substances
NF2L2_HUMAN
ZINC - Biogenic
NF2L2_HUMAN
ZINC target
Q16236
PRO
Q16236
PDB
7K2B
,
7X5F
,
7X5G
,
7O7B
,
7K2K
,
2LZ1
,
7K28
,
3ZGC
,
7K29
,
7K2C
,
7K2D
,
5WFV
,
4IFL
,
8EJR
,
7X5E
,
8EJS
,
7K2E
,
6T7V
,
7K2A
,
2FLU
HPA
ENSG00000116044-NFE2L2
GeneCards
Q16236
Ensembl
ENST00000699351
,
ENST00000699330
,
ENSP00000412191
,
ENST00000699408
,
ENST00000699409
,
ENSP00000380253
,
ENSP00000380252
,
ENST00000421929
,
ENST00000397063
,
ENSP00000514386
,
ENSP00000400073
,
ENSP00000514369
,
ENST00000699328
,
ENST00000699343
,
ENST00000397062
,
ENST00000446151
,
ENSP00000514318
,
ENSP00000411575
,
ENST00000464747
,
ENSP00000514304
,
ENSP00000514303
,
ENSP00000514325
,
ENSP00000467401
,
ENSG00000116044
,
ENSP00000514370
,
ENST00000448782
,
ENST00000699434
Pharos - Targets
Q16236
ZINC - Predictions - Purchasable
NF2L2_HUMAN
Interactors (53)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14145 KEAP1
3
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
KEAP1 [cytosol]
(R-HSA-976038)
0.978
39
UniProt:O15525 MAFG
1
MAFG [nucleoplasm]
(R-HSA-1008212)
0.939
16
UniProt:O60675 MAFK
1
MAFK [nucleoplasm]
(R-HSA-1008242)
0.806
7
UniProt:Q9ULX9 MAFF
1
MAFF [nucleoplasm]
(R-HSA-1008261)
0.77
6
UniProt:P18848 ATF4
2
ATF4 [cytosol]
(R-HSA-381084)
ATF4 [nucleoplasm]
(R-HSA-381016)
0.727
8
IntAct:EBI-4399559 UBIQ
0.667
3
UniProt:P13805 TNNT1
1
TNNT1 [cytosol]
(R-HSA-390544)
0.666
4
UniProt:O60519 CRBL2
0.625
5
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.625
5
UniProt:O15144 ARPC2
1
ARPC2 [cytosol]
(R-HSA-200809)
0.625
5
UniProt:Q10587 TEF
0.625
5
UniProt:P41212 ETV6
14
p-12Y-ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane]
(R-HSA-9673912)
p-11Y-ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane]
(R-HSA-9673905)
ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane]
(R-HSA-9673893)
ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane]
(R-HSA-9673898)
ETV6(1-384)-FLT3(569-993) fusion [cytosol]
(R-HSA-9697944)
ETV6(1-301)-FLT3(574-993) fusion [cytosol]
(R-HSA-9703315)
ETV6(1-384)-FLT3(573-993) fusion [cytosol]
(R-HSA-9703307)
ETV6(1-336)insGCS-FLT3(573-993) fusion [cytosol]
(R-HSA-9703320)
ETV6(1-154)insGSFILG-FLT3(573-993) fusion [cytosol]
(R-HSA-9703312)
ETV6(1-384)-p-3Y-FLT3(659-1620) fusion [cytosol]
(R-HSA-9703313)
ETV6(1-301)-p-6Y-FLT3(574-993) fusion [cytosol]
(R-HSA-9703318)
ETV6(1-336)insGCS-p-6Y-FLT3(573-993) fusion [cytosol]
(R-HSA-9703305)
ETV6(1-154)insGSFILG-p-6Y-FLT3(573-993) fusion [cytosol]
(R-HSA-9703302)
ETV6(1-384)-p-6Y-FLT3(573-993) fusion [cytosol]
(R-HSA-9703308)
0.625
5
UniProt:O75822 EIF3J
1
EIF3J [cytosol]
(R-HSA-72534)
0.625
5
UniProt:Q9NS37 ZHANG
0.625
5
UniProt:P53567 CEBPG
1
CEBPG [nucleoplasm]
(R-HSA-9644320)
0.625
5
UniProt:P15408 FOSL2
0.625
6
UniProt:P53539 FOSB
1
FOSB [nucleoplasm]
(R-HSA-9009922)
0.625
6
UniProt:P35638 DDIT3
1
DDIT3 [nucleoplasm]
(R-HSA-381110)
0.625
5
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.625
5
UniProt:P20226 TBP
1
TBP [nucleoplasm]
(R-HSA-83718)
0.625
5
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.625
5
UniProt:P52564 MAP2K6
3
MAP2K6 [cytosol]
(R-HSA-167998)
p-S207,T211-MAP2K6 [cytosol]
(R-HSA-206255)
p-S207,T211-MAP2K6 [nucleoplasm]
(R-HSA-450258)
0.625
5
UniProt:P43268 ETV4
1
ETV4 [nucleoplasm]
(R-HSA-5687030)
0.625
6
UniProt:P18847 ATF3
1
ATF3 [nucleoplasm]
(R-HSA-535543)
0.625
5
UniProt:P41227 NAA10
0.602
4
UniProt:Q13342 SP140
0.581
4
UniProt:O94916 NFAT5
0.581
4
UniProt:P50549 ETV1
0.581
4
UniProt:O00629 KPNA4
2
KPNA4 [cytosol]
(R-HSA-1176066)
KPNA4 [nucleoplasm]
(R-HSA-1176058)
0.581
4
UniProt:P78545 ELF3
2
ELF3 [nucleoplasm]
(R-HSA-9021353)
p-S68-ELF3 [nucleoplasm]
(R-HSA-9021349)
0.581
5
UniProt:Q9BTA9 WAC
1
WAC [nucleoplasm]
(R-HSA-8942150)
0.556
3
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.556
5
UniProt:P13805-3 TNNT1
0.556
3
UniProt:P0DTC5 M
10
M [plasma membrane]
(R-COV-9755780)
N-glycan M [virion membrane]
(R-COV-9694385)
M [virion membrane]
(R-COV-9694320)
M [endocytic vesicle membrane]
(R-COV-9694563)
N-glycan M [endocytic vesicle membrane]
(R-COV-9694738)
M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694439)
N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694446)
M [endoplasmic reticulum membrane]
(R-COV-9767620)
nascent M [endoplasmic reticulum lumen]
(R-COV-9694279)
N-glycan M [endoplasmic reticulum membrane]
(R-COV-9694684)
0.547
2
UniProt:Q60953
4
polySUMO3-K65,K160,K490-PML [nucleoplasm]
(R-MMU-3000386)
polySUMO2-K65,K160,K490-PML [nucleoplasm]
(R-MMU-3000423)
monoSUMO1-K65,160,490-PML [nucleoplasm]
(R-MMU-3000440)
PML [nucleoplasm]
(R-MMU-1031706)
0.544
2
UniProt:P11416 Rara
3
phospho-SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]
(R-MMU-5334830)
Rara [nucleoplasm]
(R-MMU-5618000)
polySUMO2-K166,K171,K399-RARA [nucleoplasm]
(R-MMU-4341042)
0.544
2
UniProt:P10276 RARA
3
SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]
(R-HSA-5334830)
polySUMO2-K166,K171,K399-RARA [nucleoplasm]
(R-HSA-4341042)
RARA [nucleoplasm]
(R-HSA-446164)
0.524
2
UniProt:Q9ULD4 BRPF3
3
BRPF3 [extracellular region]
(R-HSA-350700)
BRPF3 [cytosol]
(R-HSA-350716)
BRPF3 [nucleoplasm]
(R-HSA-3318471)
0.508
3
UniProt:Q96G23 CERS2
1
CERS2 [endoplasmic reticulum membrane]
(R-HSA-428171)
0.508
2
UniProt:P55210 CASP7
5
CASP7(24-198) [nucleoplasm]
(R-HSA-351927)
CASP7(207-303) [nucleoplasm]
(R-HSA-351924)
CASP7(2-303) [cytosol]
(R-HSA-57029)
CASP7(24-198) [cytosol]
(R-HSA-141641)
CASP7(207-303) [cytosol]
(R-HSA-141642)
0.508
2
UniProt:P15976 GATA1
1
GATA1 [nucleoplasm]
(R-HSA-996772)
0.508
2
UniProt:Q6V702 CF299
0.508
3
UniProt:Q9UJU2 LEF1
2
LEF1 [nucleoplasm]
(R-HSA-3214972)
pT155,S166-LEF1 [nucleoplasm]
(R-HSA-4411389)
0.508
3
UniProt:P52292 KPNA2
2
KPNA2 [nucleoplasm]
(R-HSA-206045)
KPNA2 [cytosol]
(R-HSA-205976)
0.508
4
UniProt:P10914 IRF1
2
IRF1 [nucleoplasm]
(R-HSA-983456)
IRF1 [cytosol]
(R-HSA-1015686)
0.508
3
UniProt:P27695 APEX1
1
APEX1 [nucleoplasm]
(R-HSA-50119)
0.508
3
UniProt:P53365 ARFIP2
1
ARFIP2 [cytosol]
(R-HSA-6813848)
0.508
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.508
2
UniProt:O75478 TADA2A
1
TADA2A [nucleoplasm]
(R-HSA-3662284)
0.508
2
UniProt:P15036 ETS2
2
p-T72-ETS2 [nucleoplasm]
(R-HSA-3132735)
ETS2 [nucleoplasm]
(R-HSA-1629811)
0.508
2
UniProt:P19419 ELK1
2
ELK1 [nucleoplasm]
(R-HSA-3009346)
p-4S,T336-ELK1 [nucleoplasm]
(R-HSA-3009350)
0.508
5
UniProt:Q77UU1 Q77UU1
0.488
2
UniProt:O95718-3 ESRRB
0.463
2
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