K48polyUb-K571,K604,K627-RIPK1 [cytosol]

Stable Identifier
R-HSA-9796639
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
K48polyUb-K571,K604,K627-RIP1, K48-linked polyUb - RIP1
K48polyUb-K571,K604,K627-RIPK1 [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
16603398 Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

Deng, L, Chen, ZJ, Pineda, G, Xia, ZP, Ea, CK

Mol Cell 2006
External Reference Information
External Reference
Gene Names
RIPK1, RIP, RIP1
Chain
chain:1-671
Other Identifiers
0006520154
11737938_a_at
11737939_a_at
11737940_s_at
11750849_a_at
11756807_a_at
17004295
209941_PM_at
209941_at
226551_PM_at
226551_at
2892343
2892344
2892345
2892349
2892350
2892352
2892355
2892356
2892357
2892358
2892359
2892363
2892364
2892372
2892373
2892375
2892376
2892377
2892378
2892379
2892383
2892385
2892386
2892387
2892388
2892389
2939062
2939063
40696_at
475_at
51161_at
8116622
8737
A_23_P370005
A_33_P3279059
GO:0000165
GO:0000166
GO:0001934
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0004706
GO:0004712
GO:0005123
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005737
GO:0005739
GO:0005768
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006915
GO:0006954
GO:0007165
GO:0008150
GO:0008219
GO:0010008
GO:0010468
GO:0010556
GO:0010940
GO:0010942
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019899
GO:0023052
GO:0030154
GO:0030163
GO:0031047
GO:0031264
GO:0031326
GO:0031410
GO:0031625
GO:0032757
GO:0032760
GO:0032991
GO:0033209
GO:0034612
GO:0036211
GO:0036289
GO:0042327
GO:0042802
GO:0042803
GO:0043065
GO:0043066
GO:0043068
GO:0043123
GO:0043124
GO:0043167
GO:0043226
GO:0043235
GO:0043410
GO:0044093
GO:0044877
GO:0045121
GO:0045651
GO:0045944
GO:0046330
GO:0046777
GO:0048856
GO:0050729
GO:0051092
GO:0055085
GO:0060545
GO:0060546
GO:0065003
GO:0070105
GO:0070231
GO:0070266
GO:0070301
GO:0070513
GO:0070926
GO:0071345
GO:0071356
GO:0071363
GO:0097191
GO:0097300
GO:0097342
GO:0097343
GO:0097527
GO:0106310
GO:1901026
GO:1903265
GO:1903800
GO:1905206
GO:1990000
GO:2000377
GO:2000379
GO:2001237
GO:2001238
GO:2001240
HMNXSV003025407
HMNXSV003028067
Hs.77273.1.A1_3p_at
Hs.77273.1.A1_3p_x_at
ILMN_1657937
ILMN_2119535
PH_hs_0018906
TC06000023.hg
TC06002463.hg
U50062_at
g3426026_3p_at
Participates
Other forms of this molecule
Inferred To
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at 571
Coordinate
571
Modification
K48polyUb [cytosol]
PsiMod Name
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at 604
Coordinate
604
Modification
K48polyUb [cytosol]
PsiMod Name
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at 627
Coordinate
627
Modification
K48polyUb [cytosol]
PsiMod Name
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
PRO
ZINC - Investigational
GeneCards
Pharos - Targets
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (23)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q14790 CASP8  8 0.959 30
 UniProt:Q9Y572 RIPK3  7 0.949 26
 UniProt:Q13158 FADD  1 0.899 11
 UniProt:Q9Y6K9 IKBKG  12 0.893 9
 UniProt:Q13546 RIPK1  15 0.892 11
 UniProt:Q12933 TRAF2  5 0.884 10
 UniProt:P19438 TNFRSF1A  2 0.839 6
 UniProt:P01375 TNF  5 0.837 9
 UniProt:Q13077 TRAF1  3 0.798 8
 UniProt:P0DTD1-PRO_0000449629 REP      0.723 5
 UniProt:Q13114 TRAF3  4 0.703 5
 UniProt:Q13490 BIRC2  5 0.697 5
 UniProt:Q13489 BIRC3  3 0.602 3
 UniProt:P48729 CSNK1A1  2 0.602 5
 UniProt:P08238 HSP90AB1  6 0.589 2
 UniProt:Q15628 TRADD  1 0.564 3
 UniProt:P04083 ANXA1  2 0.556 5
 IntAct:EBI-4399559 UBIQ      0.544 3
 UniProt:Q8IVM0 CCD50      0.524 2
 UniProt:Q13107 USP4  1 0.524 4
 UniProt:O00635 TRIM38  1 0.508 2
 UniProt:B7UI21 NLEB1      0.508 4
 UniProt:U5TQE9 U5TQE9      0.499 3
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