C3b binds to cell surface

Stable Identifier
R-HSA-981539
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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C3b binds to cell surface
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Metastable C3b can bind a wide variety of proteins and carbohydrates expressed on biological surfaces (Coico & Sunshine, 2009; Kimball 2010). This is an essentially random event (Dodds & Law, 1998); binding may be to host or microorganism. However, certain surface sugars have greater C3b binding rates, perhaps explaining variations in microorganism suceptibility (Pangburn, M. in The Complement System, Ed. Rother et al. 1998).
Literature References
PubMed ID Title Journal Year
268620 Interaction between the third complement protein and cell surface macromolecules

Levine, RP, Law, SK

Proc Natl Acad Sci U S A 1977
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Authored
Jupe, S  (2010-10-26)
Reviewed
D'Eustachio, P  (2010-11-30)
Created
Jupe, S  (2010-10-22)
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