Reactome | Expression of SHH in axial mesoderm

Expression of SHH in axial mesoderm

Stable Identifier

R-HSA-9815789

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

nucleoplasm, endoplasmic reticulum lumen

ReviewStatus

5/5

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Sonic hedgehog (SHH) is expressed during in vitro differentiation of human notochord cells (Diaz-Hernandez et al. 2020). In the notochord, SHH is activated by FOXA1 and FOXA2 (inferred from mouse homologs). SHH secreted by the notochord patterns adjacent tissue, including floor plate, somitocoele, and neural tube (inferred from mouse homologs).

Literature References

PubMed ID	Title	Journal	Year
31840817	Derivation of notochordal cells from human embryonic stem cells reveals unique regulatory networks by single cell-transcriptomics Diaz-Hernandez, ME, Khan, NM, Trochez, CM, Yoon, T, Maye, P, Presciutti, SM, Gibson, G, Drissi, H	J Cell Physiol	2020
10441331	Expression of the Sonic hedgehog (SHH ) gene during early human development and phenotypic expression of new mutations causing holoprosencephaly Odent, S, Atti-Bitach, T, Blayau, M, Mathieu, M, Aug, J, Delezo de, AL, Gall, JY, Le Marec, B, Munnich, A, David, V, Vekemans, M	Hum Mol Genet	1999