Reactome | DNTTIP1 [nucleoplasm]

DNTTIP1 [nucleoplasm]

Stable Identifier

R-HSA-9815865

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Deoxynucleotidyltransferase terminal-interacting protein 1, TDIF1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q6PJG2 MDEAS

Expand all

Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 Gene Transcription (Homo sapiens)
        
        Negative Regulation of CDH1 Gene Transcription (Homo sapiens)
        
        DNTTIP1 binds CDH1 gene promoter (Homo sapiens)
        
        DNTTIP1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H147 DNTTIP1

Gene Names

DNTTIP1, C20orf167, TDIF1

Chain

chain:1-329

Reference Genes

BioGPS Gene:116092 DNTTIP1

COSMIC (genes):DNTTIP1 DNTTIP1

CTD Gene:116092 DNTTIP1

dbSNP Gene:116092 DNTTIP1

ENSEMBL:ENSG00000101457 DNTTIP1

HGNC:16160 DNTTIP1

KEGG:hsa:116092 DNTTIP1

Monarch:116092 DNTTIP1

NCBI Entrez Gene:116092 DNTTIP1

OMIM:611388 DNTTIP1

UCSC:Q9H147 DNTTIP1

Reference Transcript

RefSeq:NM_052951.3 DNTTIP1

Other Identifiers

116092

11717201_at

16914297

224825_PM_at

224825_at

234942_PM_s_at

234942_s_at

3887019

3887020

3887021

3887022

3887023

3887024

3887025

3887026

3887027

3887029

3887030

3887031

3887032

3887033

3887034

3887035

3887036

3887037

3887038

3887039

3887040

3887041

3887042

65611_at

8063028

A_23_P131816

GE56293

GO:0000118

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0031491

GO:0042803

HMNXSV003057476

Hs.26213.0.S1_3p_at

ILMN_1691117

PH_hs_0027609

PH_hs_0035398

TC20000356.hg

Participates

as an input of

DNTTIP1 binds CDH1 gene promoter (Homo sapiens)

as a component of

DNTTIP1:CDH1 gene [nucleoplasm] (Homo sapiens)

Inferred To

DNTTIP1 [nucleoplasm] (Bos taurus)

DNTTIP1 [nucleoplasm] (Canis familiaris)

DNTTIP1 [nucleoplasm] (Sus scrofa)

saeg-2 [nucleoplasm] (Caenorhabditis elegans)

Dmel\CG42304 [nucleoplasm] (Drosophila melanogaster)

Dnttip1 [nucleoplasm] (Mus musculus)

Dnttip1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_443183.1

OpenTargets

ENSG00000101457

ENSEMBL

ENSP00000361705, ENSG00000101457, ENST00000372622

HPA

ENSG00000101457-DNTTIP1

GeneCards

DNTTIP1

PRO

Q9H147

Pharos - Targets

Q9H147

PDB

4D6K, 6Z2J, 6Z2K, 2MWI

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.877	11
UniProt:Q6PJG2 MDEAS			0.643	3
UniProt:P20248 CCNA2	5	p-S154-CCNA2 [nucleoplasm] (R-HSA-9929512) p-S154-CCNA2 [cytosol] (R-HSA-9929551) CCNA2 [nucleoplasm] (R-HSA-68905) CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099)	0.643	4
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.643	4
UniProt:Q96PN7 TREF1			0.643	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	15
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P55081 MFAP1	1	MFAP1 [nucleoplasm] (R-HSA-2396419)	0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
UniProt:Q86WV8 Q86WV8			0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P01023 A2M	2	A2M [platelet alpha granule lumen] (R-HSA-139834) A2M [extracellular region] (R-HSA-49291)	0.556	3
UniProt:P43360 MAGA6			0.556	3
UniProt:Q8IX15-3 HOMEZ			0.556	3
UniProt:P50570-2 DNM2			0.556	3
UniProt:Q92688 AN32B			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:O14656-2 TOR1A			0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:Q6NT76 HMBX1			0.556	3
UniProt:Q8TCD6 PHOP2			0.527	2
UniProt:Q96P53 WDFY2			0.527	2

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