Reactome | K63,M1polyUb, p-T189-RIPK1 [cytosol]

K63,M1polyUb, p-T189-RIPK1 [cytosol]

Stable Identifier

R-HSA-9817377

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

K63polyUb, M1polyUb, p-T189-RIPK1, K63-, M1-linked polyUb,p-T189 - RIP1

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Literature References

PubMed ID	Title	Journal	Year
16603398	Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO Deng, L, Chen, ZJ, Pineda, G, Xia, ZP, Ea, CK	Mol Cell	2006

External Reference Information

External Reference

UniProt:Q13546 RIPK1

Gene Names

RIPK1, RIP, RIP1

Chain

chain:1-671

Reference Genes

BioGPS Gene:8737 RIPK1

COSMIC (genes):RIPK1 RIPK1

CTD Gene:8737 RIPK1

dbSNP Gene:8737 RIPK1

ENSEMBL:ENSG00000137275 RIPK1

ENSEMBL_homo_sapiens_GENE:ENSG00000137275.16 RIPK1

HGNC:10019 RIPK1

KEGG Gene (Homo sapiens):8737 RIPK1

Monarch:8737 RIPK1

NCBI Gene:8737 RIPK1

OMIM:603453 RIPK1

UCSC:Q13546 RIPK1

Reference Transcript

Other Identifiers

11737938_a_at

11737939_a_at

11737940_s_at

11750849_a_at

11756807_a_at

17004295

209941_PM_at

209941_at

226551_PM_at

226551_at

2892343

2892344

2892345

2892349

2892350

2892352

2892355

2892356

2892357

2892358

2892359

2892363

2892364

2892372

2892373

2892375

2892376

2892377

2892378

2892379

2892383

2892385

2892386

2892387

2892388

2892389

2939062

2939063

40696_at

475_at

51161_at

8116622

8737

A_23_P370005

A_33_P3279059

GO:0000165

GO:0000166

GO:0001934

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004706

GO:0005123

GO:0005515

GO:0005524

GO:0005737

GO:0005739

GO:0005768

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0006915

GO:0006950

GO:0006954

GO:0006979

GO:0007165

GO:0008152

GO:0010008

GO:0010628

GO:0012501

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030154

GO:0030163

GO:0031047

GO:0031264

GO:0031349

GO:0031410

GO:0031625

GO:0032103

GO:0032757

GO:0032760

GO:0032991

GO:0033209

GO:0034612

GO:0035556

GO:0035591

GO:0036211

GO:0036289

GO:0042327

GO:0042802

GO:0042803

GO:0043065

GO:0043066

GO:0043068

GO:0043123

GO:0043124

GO:0043226

GO:0043235

GO:0043410

GO:0043525

GO:0044877

GO:0045651

GO:0045944

GO:0046330

GO:0046777

GO:0048856

GO:0050729

GO:0051092

GO:0055085

GO:0060090

GO:0060545

GO:0060546

GO:0062100

GO:0065003

GO:0070105

GO:0070231

GO:0070266

GO:0070301

GO:0070513

GO:0070926

GO:0071345

GO:0071356

GO:0071363

GO:0097191

GO:0097300

GO:0097342

GO:0097343

GO:0097527

GO:0106310

GO:0140096

GO:1900119

GO:1901026

GO:1901224

GO:1903265

GO:1903800

GO:1990000

GO:2000377

GO:2000379

GO:2001237

GO:2001238

GO:2001240

HMNXSV003025407

HMNXSV003028067

Hs.77273.1.A1_3p_at

Hs.77273.1.A1_3p_x_at

ILMN_2119535

PH_hs_0018906

TC06000023.hg

TC06002463.hg

U50062_at

g3426026_3p_at

Participates

as a component of

TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)

Other forms of this molecule

K48polyUb-RIPK1 [cytosol]

PolyUb-RIPK1 [cytosol]

RIPK1 D324N [cytosol]

RIPK1 D324Y [cytosol]

RIPK1 D324V [cytosol]

RIPK1 D324H [cytosol]

RIPK1 [plasma membrane]

K48polyUb-K571,K604,K627-RIPK1 [cytosol]

K63,Met1polyUb-p-S25-RIPK1 [cytosol]

K63,M1polyUb-RIPK1 [cytosol]

RIPK1(1-324) [cytosol]

RIPK1(325-671) [cytosol]

polyUb-K377,K604,K634-RIPK1 [cytosol]

p-S320-RIPK1 [cytosol]

p-S357-RIPK1 [cytosol]

p-S166-RIPK1 [cytosol]

K63polyUb-RIPK1 [cytosol]

RIPK1 [endosome membrane]

RIPK1 [cytosol]

Inferred To

phospho-K63,M1polyUb, p-T189-RIPK1 [cytosol] (Gallus gallus)

phospho-K63,M1polyUb, p-T189-RIPK1 [cytosol] (Mus musculus)

phospho-RIPK1 [cytosol] (Bos taurus)

phospho-RIPK1 [cytosol] (Canis familiaris)

phospho-RIPK1 [cytosol] (Sus scrofa)

phospho-Ripk1 [cytosol] (Rattus norvegicus)

Modified Residues

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 377

Coordinate

377

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (M1polyUb [cytosol]) at 627

Coordinate

627

Modification

M1polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

O-phospho-L-threonine at 189

Coordinate

189

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_005249514.2, NP_003795.2

ZINC - World Drugs

RIPK1_HUMAN

Guide to Pharmacology - Targets

2189

OpenTargets

ENSG00000137275

ZINC - FDA approved

RIPK1_HUMAN

ZINC - Substances

RIPK1_HUMAN

ZINC target

Q13546

PRO

Q13546

PDB

7CJB, 5HX6, 5V7Z, 6HHO, 4ITJ, 4NEU, 6C3E, 6NW2, 7XMK, 5TX5, 8I2N, 6R5F, 7FCZ, 6NYH, 6RLN, 7YDX, 4ITH, 6C4D, 4ITI, 6AC5, 6OCQ, 7FD0

ZINC - Investigational

RIPK1_HUMAN

HPA

ENSG00000137275-RIPK1

GeneCards

Q13546

Ensembl

ENST00000259808, ENSP00000259808, ENST00000380409, ENSP00000369773, ENSG00000137275

Pharos - Targets

Q13546

ZINC - Predictions - Purchasable

RIPK1_HUMAN

HMDB Protein

HMDBP09499

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y572 RIPK3	8	p-S199,227, K48pUb-363-RIPK3 [cytosol] (R-HSA-9686933) K33polyUb-K197,302,364-RIPK3 [cytosol] (R-HSA-9794180) OGlcNAc-T467-RIPK3 [cytosol] (R-HSA-9687819) RIPK3(329-518) [cytosol] (R-HSA-9686937) RIPK3(1-328) [cytosol] (R-HSA-9686917) RIPK3 [cytosol] (R-HSA-450328) p-S199,227-RIPK3 [cytosol] (R-HSA-5218873) Ub-K55,363-RIPK3 [cytosol] (R-HSA-9688825)	0.972	27
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.959	30
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.928	12
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.893	9
UniProt:Q13546 RIPK1	20	K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) RIPK1 D324N [cytosol] (R-HSA-9693930) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 [plasma membrane] (R-HSA-937073) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) RIPK1(1-324) [cytosol] (R-HSA-5212664) RIPK1(325-671) [cytosol] (R-HSA-5212671) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) p-S320-RIPK1 [cytosol] (R-HSA-9815498) p-S357-RIPK1 [cytosol] (R-HSA-9819116) p-S166-RIPK1 [cytosol] (R-HSA-5218872) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [endosome membrane] (R-HSA-450326) RIPK1 [cytosol] (R-HSA-168651)	0.892	11
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.884	10
UniProt:P19438 TNFRSF1A	2	TNFRSF1A(41-201) [extracellular region] (R-HSA-6785048) TNFRSF1A(30-45) [plasma membrane] (R-HSA-5675738)	0.877	7
UniProt:P01375 TNF	5	TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.837	9
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.798	8
UniProt:P0DTD1-PRO_0000449629 REP			0.788	6
UniProt:Q13114 TRAF3	4	TRAF3 R118W [cytosol] (R-HSA-5602321) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 [cytosol] (R-HSA-914241) K63polyUb-TRAF3 [cytosol] (R-HSA-936402)	0.703	5
UniProt:Q13490 BIRC2	5	K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.697	5
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.602	5
UniProt:Q13489 BIRC3	3	BIRC3 [cytosol] (R-HSA-50845) K48pUb-BIRC3 [cytosol] (R-HSA-5675478) K63polyUb-BIRC3 [cytosol] (R-HSA-5668478)	0.602	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.589	2
UniProt:Q15628 TRADD	1	TRADD [cytosol] (R-HSA-66376)	0.564	3
UniProt:P04083 ANXA1	2	ANXA1 [cytosol] (R-HSA-5263630) ANXA1 [extracellular region] (R-HSA-444539)	0.556	5
IntAct:EBI-4399559 UBIQ			0.544	3
UniProt:Q13107 USP4	1	USP4 [cytosol] (R-HSA-5212663)	0.524	4
UniProt:Q8IVM0 CCD50			0.524	2
UniProt:O00635 TRIM38	1	TRIM38 [cytosol] (R-HSA-5624325)	0.508	2
UniProt:B7UI21 NLEB1			0.508	4
UniProt:U5TQE9 U5TQE9			0.499	3
UniProt:Q96AB6 NTAN1			0.499	2

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