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SLC30A8 [Golgi membrane]
Stable Identifier
R-HSA-9817561
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
ZnT8, Zinc transporter 8
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Insulin processing (Homo sapiens)
ZnT8 transports zinc into the Golgi apparatus (Homo sapiens)
SLC30A8 dimer [Golgi membrane] (Homo sapiens)
SLC30A8 [Golgi membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Metal ion SLC transporters (Homo sapiens)
Zinc transporters (Homo sapiens)
Zinc efflux and compartmentalization by the SLC30 family (Homo sapiens)
ZnT8 transports zinc into the Golgi apparatus (Homo sapiens)
SLC30A8 dimer [Golgi membrane] (Homo sapiens)
SLC30A8 [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IWU4 SLC30A8
Gene Names
SLC30A8, ZNT8
Chain
chain:1-369
Reference Genes
BioGPS Gene:169026 SLC30A8
COSMIC (genes):SLC30A8 SLC30A8
CTD Gene:169026 SLC30A8
dbSNP Gene:169026 SLC30A8
ENSEMBL:ENSG00000164756 SLC30A8
ENSEMBL_homo_sapiens_GENE:ENSG00000164756.13 SLC30A8
HGNC:20303 SLC30A8
KEGG Gene (Homo sapiens):169026 SLC30A8
Monarch:169026 SLC30A8
NCBI Gene:169026 SLC30A8
OMIM:611145 SLC30A8
UCSC:Q8IWU4 SLC30A8
Reference Transcript
RefSeq:NM_001172811.1 SLC30A8
RefSeq:NM_001172815.2 SLC30A8
RefSeq:NM_001172814.1 SLC30A8
RefSeq:NM_173851.2 SLC30A8
RefSeq:NM_001172813.1 SLC30A8
Other Identifiers
11725814_a_at
11725815_a_at
11748812_s_at
11752953_a_at
1552985_PM_at
1552985_at
169026
17072059
239983_PM_at
239983_at
3112585
3112586
3112587
3112592
3112608
3112609
3112610
3112611
3112612
3112619
3112620
3112621
3112624
3112625
3112626
3112627
3112628
3112629
3112630
3112631
65344_at
8148003
86126_at
A_14_P138620
A_23_P362798
A_33_P3283813
GE549983
GE88788
GO:0000139
GO:0002376
GO:0005215
GO:0005385
GO:0005515
GO:0005794
GO:0005886
GO:0006811
GO:0006812
GO:0006829
GO:0006882
GO:0008270
GO:0008324
GO:0009749
GO:0010043
GO:0015297
GO:0016020
GO:0016192
GO:0023052
GO:0030070
GO:0030073
GO:0030141
GO:0030658
GO:0030667
GO:0031410
GO:0032024
GO:0034341
GO:0042803
GO:0043226
GO:0043231
GO:0046872
GO:0051604
GO:0055065
GO:0055085
GO:0060627
GO:0062111
GO:0070555
GO:0071577
GO:0071578
GO:0098542
GO:0140826
HMNXSV003003107
HMNXSV003015802
Hs.170042.0.A1_3p_at
Hs2.179082.1.S1_3p_at
ILMN_1774869
PH_hs_0010622
TC08000685.hg
Participates
as a component of
SLC30A8 dimer [Golgi membrane] (Homo sapiens)
Other forms of this molecule
SLC30A8 [secretory granule membrane]
Inferred To
ZnT41F [Golgi membrane]
(Drosophila melanogaster)
cdf-2 [Golgi membrane]
(Caenorhabditis elegans)
SLC30A8 [Golgi membrane]
(Bos taurus)
SLC30A8 [Golgi membrane]
(Canis familiaris)
SLC30A8 [Golgi membrane]
(Dictyostelium discoideum)
SLC30A8 [Golgi membrane]
(Gallus gallus)
SLC30A8 [Golgi membrane]
(Mus musculus)
SLC30A8 [Golgi membrane]
(Plasmodium falciparum)
SLC30A8 [Golgi membrane]
(Rattus norvegicus)
SLC30A8 [Golgi membrane]
(Sus scrofa)
SLC30A8 [Golgi membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001166282.1
,
NP_001166285.1
,
NP_001166284.1
,
NP_001166286.1
,
NP_776250.2
Guide to Pharmacology - Targets
1128
OpenTargets
ENSG00000164756
HPA
ENSG00000164756-SLC30A8
GeneCards
Q8IWU4
Ensembl
ENSP00000428545
,
ENSP00000431069
,
ENST00000521243
,
ENST00000519688
,
ENST00000456015
,
ENSP00000407505
,
ENSP00000415011
,
ENSG00000164756
,
ENST00000427715
PRO
Q8IWU4
Pharos - Targets
Q8IWU4
HMDB Protein
HMDBP12042
PDB
6XPE
,
6XPD
,
6XPF
Interactors (79)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.805
9
UniProt:Q8WZ55 BSND
1
BSND [plasma membrane]
(R-HSA-2854996)
0.556
3
UniProt:O60636 TSN2
0.556
3
UniProt:Q9NPE6 SPAG4
0.556
3
UniProt:P23763-3 VAMP1
0.556
3
UniProt:Q8NC24 RELL2
0.556
3
UniProt:Q99675 CGRF1
0.556
3
UniProt:Q96KR6 F210B
0.556
3
UniProt:P15941-11 MUC1
0.556
3
UniProt:Q99640-2 PKMYT1
0.556
3
UniProt:Q9BSR8 YIPF4
0.556
3
UniProt:Q8IV31 TM139
0.556
3
UniProt:P30519 HMOX2
3
HMOX2 [plasma membrane]
(R-HSA-6799676)
HMOX2 [specific granule membrane]
(R-HSA-6799628)
HMOX2 [endoplasmic reticulum membrane]
(R-HSA-189391)
0.556
3
UniProt:Q9P0T7 TMEM9
0.556
3
UniProt:Q9BUN8 DERL1
1
DERL1 [endoplasmic reticulum membrane]
(R-HSA-6781898)
0.556
3
IntAct:EBI-22589183 CCSB ORF ID
0.556
3
UniProt:Q8WV19 SFT2A
0.556
3
UniProt:Q96MG2 JSPR1
0.556
3
IntAct:EBI-23641393 CCSB ORF ID
0.556
3
UniProt:Q96EC8 YIPF6
2
YIPF6 [Golgi membrane]
(R-HSA-434346)
YIPF6 [cytoplasmic vesicle membrane]
(R-HSA-434199)
0.556
3
UniProt:Q9NVJ2 ARL8B
0.556
3
UniProt:Q99726 SLC30A3
1
SLC30A3 [synaptic vesicle membrane]
(R-HSA-437087)
0.556
3
UniProt:P63027 VAMP2
20
VAMP2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869129)
VAMP2 [clathrin-sculpted monoamine transport vesicle membrane]
(R-HSA-379363)
VAMP2 [plasma membrane]
(R-HSA-210516)
VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-917738)
VAMP2 [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-210365)
VAMP2 [synaptic vesicle membrane]
(R-HSA-181517)
VAMP2(59-116) [synaptic vesicle membrane]
(R-HSA-5250891)
VAMP2(2-58) [cytosol]
(R-HSA-194815)
VAMP2(2-76) [cytosol]
(R-HSA-194802)
VAMP2(77-116) [synaptic vesicle membrane]
(R-HSA-5228355)
VAMP2(60-116) [synaptic vesicle membrane]
(R-HSA-5250615)
VAMP2(2-59) [cytosol]
(R-HSA-194797)
VAMP2(82-116) [synaptic vesicle membrane]
(R-HSA-5250961)
VAMP2(2-81) [cytosol]
(R-HSA-5250970)
VAMP2 [secretory granule membrane]
(R-HSA-376363)
VAMP2 [cytosol]
(R-HSA-9609882)
VAMP2 [endoplasmic reticulum membrane]
(R-HSA-9609886)
VAMP2 [cytoplasmic vesicle membrane]
(R-HSA-1449630)
VAMP2 [lysosomal membrane]
(R-HSA-432703)
VAMP2 [Golgi membrane]
(R-HSA-375425)
0.556
3
UniProt:Q9NY72 SCN3B
1
SCN3B [plasma membrane]
(R-HSA-197921)
0.556
3
UniProt:Q4KMG9 TM52B
0.556
3
UniProt:Q9NP94 SLC39A2
1
SLC39A2 [plasma membrane]
(R-HSA-442395)
0.556
3
UniProt:Q9H6H4 REEP4
0.556
3
UniProt:Q5JX71 F209A
0.556
3
UniProt:P56747 CLDN6
2
CLDN6 [plasma membrane]
(R-HSA-419992)
CLDN6 [cell junction]
(R-HSA-421250)
0.556
3
UniProt:P26678 PLN
2
p-S16-PLN [sarcoplasmic reticulum membrane]
(R-HSA-5578813)
PLN [sarcoplasmic reticulum membrane]
(R-HSA-5490319)
0.556
3
UniProt:Q9GZR5 ELOVL4
1
ELOVL4 [endoplasmic reticulum membrane]
(R-HSA-548705)
0.556
3
UniProt:Q8N9I0 SYT2
3
SYT2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869116)
SYT2 [plasma membrane]
(R-HSA-168795)
SYT2 [synaptic vesicle membrane]
(R-HSA-194786)
0.556
3
UniProt:Q16617 NKG7
0.556
3
UniProt:Q5T4F4 ZFY27
0.556
3
UniProt:Q96FZ5 CKLF7
0.556
3
UniProt:Q96HE8 TMM80
0.556
3
UniProt:P13236 CCL4
1
CCL4(24-92) [extracellular region]
(R-HSA-443976)
0.556
3
IntAct:EBI-22326698 CCSB ORF ID
0.556
3
UniProt:O95197-3 RTN3
0.556
3
UniProt:P16157-17 ANK1
0.556
3
UniProt:Q9HD20-3 ATP13A1
0.556
3
UniProt:Q8TBE3 FNDC9
0.556
3
UniProt:Q8WY91 THAP4
0.556
3
UniProt:O95562 SFT2B
0.556
3
UniProt:Q9NUU6 OTULL
0.556
3
UniProt:Q8N2H4 SYS1
1
SYS1 [trans-Golgi network membrane]
(R-HSA-6813921)
0.556
3
UniProt:Q9NP66 HM20A
0.556
3
UniProt:O95807 TM50A
0.556
3
UniProt:Q8WWF3 SSMM1
0.556
3
UniProt:Q9NUH8 TM14B
0.556
3
UniProt:Q96HR9-2 REEP6
0.556
3
UniProt:P60508 SYCY2
0.556
3
UniProt:O15529 GPR42
0.556
3
UniProt:Q9Y282 ERGI3
0.556
3
UniProt:Q9Y6D0 SELK
0.556
3
UniProt:Q9BTX3 TM208
0.556
3
UniProt:Q96GQ5 RUSF1
0.556
3
UniProt:Q96Q45-2 TMEM237
0.556
3
UniProt:Q7Z7G2 CPLX4
0.556
3
UniProt:Q96TC7 RMD3
0.556
3
UniProt:Q9C0I4 THSD7B
3
THSD7B [endoplasmic reticulum lumen]
(R-HSA-5173101)
glc-fuc-THSD7B [endoplasmic reticulum lumen]
(R-HSA-5172957)
O-fuc-THSD7B [endoplasmic reticulum lumen]
(R-HSA-5173124)
0.556
3
UniProt:Q9P0S3 ORMDL1
1
ORMDL1 [endoplasmic reticulum membrane]
(R-HSA-8865584)
0.556
3
UniProt:Q14416 GRM2
1
GRM2 [plasma membrane]
(R-HSA-420468)
0.556
3
UniProt:Q96IV6 FXDC2
0.556
3
UniProt:Q9NR31 SAR1A
0.556
3
UniProt:P43378 PTPN9
1
PTPN9 [nucleoplasm]
(R-HSA-9008907)
0.556
3
UniProt:Q9BXK5 B2L13
0.556
3
UniProt:Q13520 AQP6
1
AQP6 [transport vesicle membrane]
(R-HSA-431741)
0.556
3
UniProt:P54219-3 P542193
0.556
3
UniProt:Q13323 BIK
0.556
3
UniProt:Q8NBQ5 HSD17B11
1
HSD17B11 [cytosol]
(R-HSA-5693370)
0.556
3
UniProt:P17152 TMEM11
1
TMEM11 [mitochondrial inner membrane]
(R-HSA-8949578)
0.556
3
UniProt:P12004 PCNA
5
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
PCNA [nucleoplasm]
(R-HSA-68439)
0.556
3
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.556
3
UniProt:O15173 PGRMC2
4
PGRMC2 [nuclear envelope]
(R-HSA-9707674)
PGRMC2 [nucleoplasm]
(R-HSA-9707859)
PGRMC2 [endoplasmic reticulum membrane]
(R-HSA-9714349)
PGRMC2 [endosome membrane]
(R-HSA-9715090)
0.556
3
UniProt:O60883 GPR37L1
1
GPR37L1 [plasma membrane]
(R-HSA-5336178)
0.556
3
UniProt:A8MZ59 LEUTX
1
LEUTX [nucleoplasm]
(R-HSA-9817277)
0.556
3
UniProt:Q8TCZ2 CD99L2
1
CD99L2 [plasma membrane]
(R-HSA-8867207)
0.556
3
UniProt:P08563-PRO_0000041304
0.524
2
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