Reactome | ST6GALNAC1 [Golgi membrane]

ST6GALNAC1 [Golgi membrane]

Stable Identifier

R-HSA-981856

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, SIA7A_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Sialic acid metabolism (Homo sapiens)
        
        ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Homo sapiens)
        
        ST6GALNAC1-6 [Golgi membrane] (Homo sapiens)
        
        ST6GALNAC1 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NSC7 ST6GALNAC1

Gene Names

ST6GALNAC1, SIAT7A, UNQ543/PRO848

Chain

chain:1-600

Reference Genes

BioGPS Gene:55808 ST6GALNAC1

COSMIC (genes):ST6GALNAC1 ST6GALNAC1

CTD Gene:55808 ST6GALNAC1

dbSNP Gene:55808 ST6GALNAC1

ENSEMBL:ENSG00000070526 ST6GALNAC1

ENSEMBL_homo_sapiens_GENE:ENSG00000070526.15 ST6GALNAC1

HGNC:23614 ST6GALNAC1

KEGG Gene (Homo sapiens):55808 ST6GALNAC1

Monarch:55808 ST6GALNAC1

NCBI Gene:55808 ST6GALNAC1

OMIM:610138 ST6GALNAC1

UCSC:Q9NSC7 ST6GALNAC1

Reference Transcript

RefSeq:NM_018414.4 ST6GALNAC1

Other Identifiers

11756588_a_at

16849286

227725_PM_at

227725_at

3771713

3771714

3771715

3771717

3771719

3771720

3771721

3771722

3771723

3771725

3771726

3771727

3771728

3771729

3771735

3771736

55808

75647_at

8018774

8180414

89741_at

A_23_P54968

GO:0000139

GO:0001665

GO:0003824

GO:0005515

GO:0005794

GO:0005975

GO:0006486

GO:0008373

GO:0009312

GO:0016020

GO:0016740

GO:0016757

GO:0036211

GO:0043226

GO:0048874

GO:0051851

GO:1901135

HMNXSV003025433

Hs.105352.0.S1_3p_at

ILMN_1772951

PH_hs_0005855

TC17001904.hg

Participates

as a member of

ST6GALNAC1-6 [Golgi membrane] (Homo sapiens)

Inferred To

ST6GALNAC1 [Golgi membrane] (Bos taurus)

ST6GALNAC1 [Golgi membrane] (Canis familiaris)

ST6GALNAC1 [Golgi membrane] (Gallus gallus)

ST6GALNAC1 [Golgi membrane] (Sus scrofa)

si:ch211-51n14.2 [Golgi membrane] (Danio rerio)

St6galnac1 [Golgi membrane] (Mus musculus)

St6galnac1 [Golgi membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_060884.1

OpenTargets

ENSG00000070526

GeneCards

Q9NSC7

HPA

ENSG00000070526-ST6GALNAC1

Ensembl

ENSP00000156626, ENST00000156626, ENSG00000070526

PRO

Q9NSC7

Pharos - Targets

Q9NSC7

HMDB Protein

HMDBP11953

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.508	5

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