Reactome | CysO572-ATG7-GARABAPL2 [cytosol]

CysO572-ATG7-GARABAPL2 [cytosol]

Stable Identifier

R-HSA-9820413

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Autophagy-related protein 7

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O95352 ATG7

Gene Names

ATG7, APG7L

Chain

initiator methionine:, chain:2-703

Reference Genes

BioGPS Gene:10533 ATG7

COSMIC (genes):ATG7 ATG7

CTD Gene:10533 ATG7

dbSNP Gene:10533 ATG7

ENSEMBL:ENSG00000197548 ATG7

HGNC:16935 ATG7

KEGG:hsa:10533 ATG7

Monarch:10533 ATG7

NCBI Gene:10533 ATG7

OMIM:608760 ATG7

UCSC:O95352 ATG7

Reference Transcript

Participates

as a member of

CysO572-ATG7-LC3 [cytosol] (Homo sapiens)

Other forms of this molecule

ATG7 [cytosol]

CysO572-ATG7 [cytosol]

CysO572-ATG7-GARABAPL3 [cytosol]

CysO572-ATG7-MAP1LC3A [cytosol]

CysO572-ATG7-MAP1LC3C [cytosol]

CysO572-ATG7-GARABAPL1 [cytosol]

CysO572-ATG7-GARABAP [cytosol]

CysO572-ATG7-MAP1LC3B [cytosol]

ATG7(1-693)-p-BRAF(381-766) fusion [cytosol]

ATG7(1-693)-BRAF(381-766) fusion [cytosol]

ATG7 [ficolin-1-rich granule lumen]

ATG7 [extracellular region]

ATG7 [secretory granule lumen]

Inferred To

CysO572-ATG7-GARABAPL2 [cytosol] (Plasmodium falciparum)

atg-7 [cytosol] (Caenorhabditis elegans)

Atg7 [cytosol] (Drosophila melanogaster)

Atg7 [cytosol] (Mus musculus)

Atg7 [cytosol] (Rattus norvegicus)

atg7 [cytosol] (Dictyostelium discoideum)

atg7 [cytosol] (Schizosaccharomyces pombe)

atg7 [cytosol] (Xenopus tropicalis)

ATG7 [cytosol] (Bos taurus)

ATG7 [cytosol] (Canis familiaris)

ATG7 [cytosol] (Gallus gallus)

ATG7 [cytosol] (Saccharomyces cerevisiae)

ATG7 [cytosol] (Sus scrofa)

Modified Residues

Name

Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 572 and 116

Coordinate

572

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

XP_011531588.1, NP_006386.1, XP_016861034.1, XP_016861035.1, XP_016861033.1, NP_001129503.2, NP_001138384.1, XP_011531584.1

OpenTargets

ENSG00000197548

ENSEMBL

ENSG00000197548, ENSP00000412580, ENST00000354449, ENST00000354956, ENSP00000346437, ENST00000693202, ENST00000685771, ENSP00000347042, ENST00000446450, ENSP00000509725, ENSP00000510336

GeneCards

ATG7

HPA

ENSG00000197548-ATG7

ZINC - Substances

ATG7_HUMAN

ZINC target

O95352

PRO

O95352

Pharos - Targets

O95352

GlyGen

O95352

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [autophagosome membrane] (R-HSA-5683641)	0.743	7
UniProt:Q9H0Y0 ATG10	2	GlyK166-ATG10 [cytosol] (R-HSA-5683572) ATG10 [cytosol] (R-HSA-5671733)	0.643	3
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.602	3
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.527	2
UniProt:Q9NT62 ATG3	8	CysO264-ATG3-GABARAPL3 [cytosol] (R-HSA-5683569) CysO264-ATG3-MAP1LC3B [cytosol] (R-HSA-9819365) CysO264-ATG3-GABARAPL1 [cytosol] (R-HSA-9819381) CysO264-ATG3-MAP1LC3C [cytosol] (R-HSA-9819377) CysO264-ATG3-GABARAPL2 [cytosol] (R-HSA-9819376) CysO264-ATG3-GABARAP [cytosol] (R-HSA-9819379) CysO264-ATG3-MAP1LC3A [cytosol] (R-HSA-9819371) ATG3 [cytosol] (R-HSA-5671860)	0.527	4
UniProt:Q99538 LGMN	2	LGMN [endolysosome lumen] (R-HSA-8942384) LGMN [lysosomal lumen] (R-HSA-350135)	0.527	2
UniProt:P29692 EEF1D	1	EEF1D [cytosol] (R-HSA-156914)	0.524	2
UniProt:P14316 IRF2	2	IRF2 [cytosol] (R-HSA-1015681) IRF2 [nucleoplasm] (R-HSA-994031)	0.499	2

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