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Defects of platelet adhesion to exposed collagen
Stable Identifier
R-HSA-9823587
DOI
10.3180/R-HSA-9823587.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Disease (Homo sapiens)
Diseases of hemostasis (Homo sapiens)
Defects of platelet adhesion to exposed collagen (Homo sapiens)
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This Reactome module describes dysfunctions in platelet adhesion caused by mutations in different genes, including VWF, ADAMTS13 and GP1BA.
Participants
Events
Defective VWF binding to collagen type I
(Homo sapiens)
Defective binding of VWF variant to GPIb:IX:V
(Homo sapiens)
Defective VWF cleavage by ADAMTS13 variant
(Homo sapiens)
Enhanced cleavage of VWF variant by ADAMTS13
(Homo sapiens)
Enhanced binding of GP1BA variant to VWF multimer:collagen
(Homo sapiens)
Participates
as an event of
Diseases of hemostasis (Homo sapiens)
Disease
Name
Identifier
Synonyms
blood platelet disease
DOID:2218
platelet disorder, Thrombocytopathy
autoimmune thrombocytopenic purpura
DOID:8924
idiopathic thrombocytopenic purpura, werlhof's disease, Ideopath thrombocytopenic pur, Autoimmune thrombocytopenic purpura, Idiopathic purpura, Immune thrombocytopenic purpura, primary thrombocytopenic purpura
Authored
Shamovsky, V (2023-01-07)
Reviewed
Gao, R (2023-11-06)
Created
Shamovsky, V (2023-01-07)
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