p-S133-CREB1 binds MITF promoter

Stable Identifier
R-HSA-9824653
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Alpha-melanocyte-stimulating hormone (alpha MSH) stimulates transcription of MITF in developing melanocytes and in melanoma cells by promoting the cAMP-dependent phosphorylation of CREB1. Phosphorylated CREB1 binds to a CRE element in the MITF-M promoter as assessed by electrophoretic mobility shift assay and stimulates transcription of MITF (Bertolotto et al,1998; Price et al, 1998). CREB-stimulated transcriptional activation of the MITF-M promoter is also dependent on the upstream SOX10 binding site (Huber et al, 2003).
Literature References
PubMed ID Title Journal Year
9830058 alpha-Melanocyte-stimulating hormone signaling regulates expression of microphthalmia, a gene deficient in Waardenburg syndrome

Fisher, DE, Wells, AG, Weilbaecher, KN, Takemoto, CM, Horstmann, MA, Landis, MW, Price, ER

J Biol Chem 1998
9700169 Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes

Hemesath, TJ, Abbe, P, Bille, K, Ballotti, R, Bertolotto, C, Fisher, DE, Ortonne, JP

J Cell Biol 1998
12944398 A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes

Widlund, HR, Davis, IJ, Wegner, M, Fisher, DE, Price, ER, Huber, WE, Du, J

J Biol Chem 2003
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