Reactome | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7

Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7

Stable Identifier

R-HSA-9824878

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
        
        Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Homo sapiens)

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Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7

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Production of type I IFN genes in response to Toll-like receptor 3 (TLR3) and TLR4 ligands is mediated by TANK-binding kinase 1 (TBK1) or I-kappa-B kinase epsilon (IKKε, IKBKE), which phosphorylate IFN regulatory factor 3 (IRF3) and IRF7. The activity of TBK1 and/or IRF3, IRF7 is regulated by multiple mechanisms including post-translational modifications, protein-protein interactions, and protein degradation (Zhao W et al., 2013; Runde AP et al., 2022).

This Reactome module describes regulation of TBK1, IKKε activity by K63-linked ubiquitination of TBK1 and IKKε, and TBK1 interaction with OPTN.
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Literature References

PubMed ID	Title	Journal	Year
23395611	Negative regulation of TBK1-mediated antiviral immunity Zhao, W	FEBS Lett	2013
35395857	The role of TBK1 in cancer pathogenesis and anticancer immunity Zhang, J, Mack, R, S J, PB, Runde, AP	J Exp Clin Cancer Res	2022