Growth hormone receptor dimerizes

Stable Identifier
R-HSA-982775
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

The growth hormone receptor forms dimers (Cunningham et al. 1991) that subsequently signal via JAK2 (Argetsinger et al. 1993). Early studies suggested that dimerization occured following ligand binding, but it is now generally accepted that dimerization is independent of ligand binding and involves the transmembrane and juxtamembrane domains (van den Eijnden et al. 2006, Brown et al. 2005).

Literature References
PubMed ID Title Journal Year
1948064 Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule

Cunningham, BC, Ultsch, M, de Vos, AM, Mulkerrin, MG, Clauser, KR, Wells, JA

Science 1991
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