Growth hormone receptor dimerizes

Stable Identifier
R-HSA-982775
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Growth hormone receptor dimerizes
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The growth hormone receptor forms dimers (Cunningham et al. 1991) that subsequently signal via JAK2 (Argetsinger et al. 1993). Early studies suggested that dimerization occured following ligand binding, but it is now generally accepted that dimerization is independent of ligand binding and involves the transmembrane and juxtamembrane domains (van den Eijnden et al. 2006, Brown et al. 2005). Binding of growth hormone binding protein (GHBP) to growth hormone receptor (GHR) produces 'unproductive' dimers that prevent formation of signaling-capable GHR dimers (Ross et al. 1997).
Literature References
PubMed ID Title Journal Year
1948064 Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule

de Vos, AM, Ultsch, M, Mulkerrin, MG, Wells, JA, Cunningham, BC, Clauser, KR

Science 1991
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
GHBP:GHR [plasma membrane] (Homo sapiens)
Orthologous Events
Growth hormone receptor dimerizes (Danio rerio)
Growth hormone receptor dimerizes (Gallus gallus)
Growth hormone receptor dimerizes (Mus musculus)
Growth hormone receptor dimerizes (Rattus norvegicus)
Authored
Jupe, S  (2010-10-14)
Reviewed
Herington, AC  (2011-06-13)
Waters, MJ  (2011-06-23)
Created
Jupe, S  (2010-10-28)
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