Growth hormone binds the growth hormone receptor

Stable Identifier
R-HSA-982778
Type
Reaction
Species
Homo sapiens
Compartment
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The growth hormone receptor (GHR) belongs to the superfamily of transmembrane proteins that includes the prolactin receptor and a number of class 1 cytokine receptors. It exists in two forms, full-length membrane-bound receptor with a single transmembrane region, and growth hormone binding protein (GHBP), a shorter soluble form corresponding to the extracellular domain of the full-length receptor. In rodents GHBP is encoded by a specific mRNA variant while in humans it results from proteolytic cleavage of the membrane receptor by a metalloprotease. The classical view is that growth hormone sequentially binds 2 molecules of GHR inducing dimerization, but it is now widely accepted that GHR dimers exist prior to ligand binding (Poger & Mark 2010).

Literature References
PubMed ID Title Journal Year
1549776 Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

de Vos, AM, Ultsch, M, Kossiakoff, AA

Science 1992
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