Growth hormone receptor binds JAK2

Stable Identifier
R-HSA-982792
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

JAKs bind to the box1 motif (residues 297-305) of the Growth Hormone Receptor (GHR) (Argetsinger et al. 1993), a proline-rich region just inside the cell membrane. Binding is mediated largely by the JAK N-terminal FERM domain (Frank et al. 1995, He et al. 2003). JAK 2 binding enhances the stability of GHR (He et al. 2005).

Literature References
PubMed ID Title Journal Year
8343952 Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

Argetsinger, LS, Campbell, GS, Yang, X, Witthuhn, BA, Silvennoinen, O, Ihle, JN, Carter-Su, C

Cell 1993
Participants
Participant Of
Orthologous Events
Authored
Reviewed