Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation

Stable Identifier
R-HSA-9828211
Type
Pathway
Species
Homo sapiens
Synonyms
Regulation of TBK1, IKBKE-mediated activation of IRF3, IRF7 upon TLR3 ligation
ReviewStatus
5/5
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Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
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Production of type I IFN genes in response to Toll-like receptor 3 (TLR3) and TLR4 ligands is mediated by TANK-binding kinase 1 (TBK1) or I-kappa-B kinase epsilon (IKKε, IKBKE), which phosphorylate IFN regulatory factor 3 (IRF3) and IRF7. The activity of TBK1 and/or IRF3, IRF7 is regulated by multiple mechanisms including post-translational modifications, protein-protein interactions, and protein degradation (Zhao W et al., 2013; Runde AP et al., 2022).

This Reactome module describes regulation of TBK1, IKKε activity by K63-linked ubiquitination of TBK1 and IKKε, and TBK1 interaction with OPTN.

Literature References
PubMed ID Title Journal Year
23395611 Negative regulation of TBK1-mediated antiviral immunity

Zhao, W

FEBS Lett 2013
35395857 The role of TBK1 in cancer pathogenesis and anticancer immunity

Zhang, J, Mack, R, S J, PB, Runde, AP

J Exp Clin Cancer Res 2022
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BioModels Database
Authored
Shamovsky, V  (2023-02-10)
Reviewed
Munitić, I  (2024-02-28)
Franjkić, T  (2024-02-28)
Created
Shamovsky, V  (2023-02-10)
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