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CANX [integral component of lumenal side of endoplasmic reticulum membrane]
Stable Identifier
R-HSA-983091
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
integral component of lumenal side of endoplasmic reticulum membrane
Synonyms
Calnexin (CANX)
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Homo sapiens)
Chaperones calnexin/BiP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
CANX [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
monoglucosylated MHC class I HC:Calnexin/BiP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
Chaperones calnexin/BiP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
CANX [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
Interaction of Erp57 with MHC class I HC (Homo sapiens)
MHC class I HC:Calnexin/BiP:Erp57 [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
monoglucosylated MHC class I HC:Calnexin/BiP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
Chaperones calnexin/BiP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
CANX [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
monoglucosylated MHC class I HC:Calnexin/BiP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
Chaperones calnexin/BiP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
CANX [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
Interaction of beta-2-microglobulin (B2M) chain with class I HC (Homo sapiens)
Chaperones calnexin/BiP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
CANX [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
MHC class I HC:Calnexin/BiP:Erp57 [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
monoglucosylated MHC class I HC:Calnexin/BiP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
Chaperones calnexin/BiP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
CANX [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P27824 CANX
Gene Names
CANX
Chain
signal peptide:1-20, chain:21-592
Reference Genes
BioGPS Gene:821 CANX
COSMIC (genes):CANX CANX
CTD Gene:821 CANX
dbSNP Gene:821 CANX
ENSEMBL:ENSG00000127022 CANX
ENSEMBL:ENSG00000127022.16 CANX
ENSEMBL:ENSG00000283777.2 CANX
HGNC:1473 CANX
KEGG Gene (Homo sapiens):821 CANX
Monarch:821 CANX
NCBI Gene:821 CANX
OMIM:114217 CANX
UCSC:P27824 CANX
Reference Transcript
RefSeq:XM_011534665.2 CANX
RefSeq:NM_001024649.1 CANX
RefSeq:NM_001746.3 CANX
Other Identifiers
0002320095
0004780035
11727421_a_at
11727422_s_at
11727423_a_at
11727424_s_at
11727425_s_at
11727426_a_at
11741127_s_at
11745457_a_at
16656823
16656825
16656827
16656829
16656831
16656833
16993397
18670177
18670178
18670179
18670180
18670181
18670182
18670183
18670184
18670185
18670186
18670187
18670189
18670190
18670192
18670193
18670194
18670195
18670196
18670197
18670199
18670200
18670201
18670202
200068_PM_s_at
200068_s_at
208852_PM_s_at
208852_s_at
208853_PM_s_at
208853_s_at
238034_PM_at
238034_at
238138_PM_at
238138_at
2844192
2844193
2844204
2844205
2844206
2844207
2844209
2844212
2844213
2844214
2844215
2844217
2844219
2844222
2844226
2844227
2844228
2844229
2844230
2844231
2844233
2844235
2844238
2844241
2844242
2844243
2844244
2844245
2844246
2844247
2844248
2844249
2844250
2844251
2844253
2844255
2844263
2844411
2844412
2844413
2844414
2844415
2844416
2844417
40125_at
53131_at
57826_at
7892514
7892972
7893103
7893270
7893272
7893345
7893632
7893641
7893642
7893880
7894074
7894674
7894687
7894725
7894878
7895017
7895188
7895276
7895283
7895334
7895475
7895547
7895693
7896020
7896050
7896136
7896308
7896387
7896430
7896644
8110522
821
83775_at
A_23_P147185
A_24_P345993
A_33_P3325131
GE57598
GE85806
GO:0003674
GO:0003723
GO:0005509
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005783
GO:0005788
GO:0005789
GO:0005790
GO:0005791
GO:0005840
GO:0005886
GO:0006457
GO:0007568
GO:0008150
GO:0009306
GO:0016020
GO:0016021
GO:0016192
GO:0019082
GO:0030163
GO:0030246
GO:0030424
GO:0030433
GO:0031410
GO:0032839
GO:0032991
GO:0034185
GO:0034975
GO:0035255
GO:0042470
GO:0043025
GO:0043167
GO:0043197
GO:0043226
GO:0044233
GO:0044322
GO:0046872
GO:0048488
GO:0051082
GO:0070062
GO:0071556
GO:0072583
GO:0098978
GO:0099055
GO:0099059
HMNXSV003013314
Hs.155560.0.S2_3p_a_at
Hs.157515.0.A1_3p_at
Hs.43679.0.A1_3p_at
ILMN_1762825
ILMN_2401057
L10284_at
PH_hs_0009368
TC05001050.hg
g179831_3p_a_at
g306480_3p_a_at
Participates
as a member of
Chaperones calnexin/BiP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
CANX [endoplasmic reticulum lumen]
Inferred To
canx [integral component of lumenal side of endoplasmic reticulum membrane]
(Xenopus tropicalis)
cnxA [integral component of lumenal side of endoplasmic reticulum membrane]
(Dictyostelium discoideum)
CANX [integral component of lumenal side of endoplasmic reticulum membrane]
(Bos taurus)
CANX [integral component of lumenal side of endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CANX [integral component of lumenal side of endoplasmic reticulum membrane]
(Canis familiaris)
CANX [integral component of lumenal side of endoplasmic reticulum membrane]
(Danio rerio)
CANX [integral component of lumenal side of endoplasmic reticulum membrane]
(Gallus gallus)
CANX [integral component of lumenal side of endoplasmic reticulum membrane]
(Mus musculus)
CANX [integral component of lumenal side of endoplasmic reticulum membrane]
(Rattus norvegicus)
CANX [integral component of lumenal side of endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
CANX [integral component of lumenal side of endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
CANX [integral component of lumenal side of endoplasmic reticulum membrane]
(Sus scrofa)
Cnx99A [integral component of lumenal side of endoplasmic reticulum membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001019820.1
,
NP_001737.1
,
XP_011532967.1
OpenTargets
ENSG00000127022
GeneCards
P27824
HPA
ENSG00000127022-CANX
Ensembl
ENST00000506654
,
ENST00000681168
,
ENSP00000506051
,
ENST00000680092
,
ENST00000680013
,
ENST00000638706
,
ENST00000504734
,
ENSP00000506003
,
ENSP00000505202
,
ENST00000509563
,
ENST00000502296
,
ENST00000452673
,
ENSP00000247461
,
ENST00000680827
,
ENSP00000505013
,
ENSP00000506078
,
ENSP00000505960
,
ENST00000247461
,
ENSG00000283777
,
ENST00000681903
,
ENSP00000492868
,
ENST00000680618
,
ENSP00000506568
,
ENSP00000505129
,
ENSP00000505526
,
ENSP00000421813
,
ENST00000681712
,
ENST00000639938
,
ENSP00000506583
,
ENSP00000506021
,
ENSP00000492372
,
ENSP00000426555
,
ENSG00000127022
,
ENST00000638425
,
ENSP00000424063
,
ENSP00000491760
,
ENSP00000424745
,
ENSP00000391646
,
ENSP00000421434
,
ENSP00000506061
,
ENST00000681674
,
ENST00000680006
,
ENST00000681476
,
ENST00000680042
,
ENST00000681733
,
ENST00000513246
,
ENSP00000506509
,
ENST00000681072
PRO
P27824
Pharos - Targets
P27824
HMDB Protein
HMDBP07535
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.813
14
UniProt:P43307 SSR1
1
SSR1 [endoplasmic reticulum membrane]
(R-HSA-444588)
0.708
6
UniProt:P04578 env
7
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
ENV [viral envelope]
(R-HIV-173439)
0.623
3
UniProt:P35610 SOAT1
1
SOAT1 [endoplasmic reticulum membrane]
(R-HSA-8876490)
0.615
4
UniProt:P61619 SEC61A1
2
SEC61A1 [endoplasmic reticulum membrane]
(R-HSA-444591)
SEC61A1 [phagocytic vesicle membrane]
(R-HSA-1236813)
0.597
4
UniProt:O95477 ABCA1
11
ABCA1 [endoplasmic reticulum membrane]
(R-HSA-5682105)
4xPALM-C-ABCA1 [plasma membrane]
(R-HSA-5682091)
4xPALM-C-ABCA1 [endoplasmic reticulum membrane]
(R-HSA-5682085)
ABCA1 Q537R [plasma membrane]
(R-HSA-5682199)
ABCA1 R587W [plasma membrane]
(R-HSA-5682197)
ABCA1 S1446L [plasma membrane]
(R-HSA-5682195)
ABCA1 C1417R [plasma membrane]
(R-HSA-5682190)
ABCA1 N935S [plasma membrane]
(R-HSA-5682200)
ABCA1 W590S [plasma membrane]
(R-HSA-5682201)
4xPALM-C-p-2S-ABCA1 [plasma membrane]
(R-HSA-5682069)
ABCA1 [plasma membrane]
(R-HSA-194209)
0.576
8
UniProt:Q8N766 EMC1
0.569
4
UniProt:P04844 RPN2
1
RPN2 [endoplasmic reticulum membrane]
(R-HSA-264937)
0.569
3
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 A775_G776insYVMA [plasma membrane]
(R-HSA-9665656)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.569
3
UniProt:Q921T2
1
Tor1aip1 [cytosol]
(R-MMU-9715083)
0.564
2
UniProt:Q7LFX5 CHST15
1
CHST15 [Golgi membrane]
(R-HSA-1971543)
0.564
2
UniProt:Q8TCJ2 STT3B
0.528
3
UniProt:P45880 VDAC2
2
VDAC2 [mitochondrial outer membrane]
(R-HSA-5696880)
PolyUb-VDAC2 [mitochondrial outer membrane]
(R-HSA-6783185)
0.527
2
UniProt:Q9H5K3 POMK
1
POMK [endoplasmic reticulum membrane]
(R-HSA-8879120)
0.527
2
UniProt:P48039 MTNR1A
1
MTNR1A [plasma membrane]
(R-HSA-419316)
0.527
2
UniProt:P49286 MTNR1B
1
MTNR1B [plasma membrane]
(R-HSA-419349)
0.527
2
UniProt:P16615 ATP2A2
2
ATP2A2 [endoplasmic reticulum membrane]
(R-HSA-391962)
ATP2A2 [platelet dense tubular network membrane]
(R-HSA-427903)
0.527
2
UniProt:O94905 ERLIN2
3
ERLIN2 [endoplasmic reticulum membrane]
(R-HSA-8866520)
ERLIN2(1-185):FGFR1(c.-88-822) fusion [plasma membrane]
(R-HSA-8853148)
ERLIN2(1-185):p-8Y FGFR1(c.-88-822) fusion [plasma membrane]
(R-HSA-8853122)
0.527
2
UniProt:Q9UIQ6 LNPEP
3
LNPEP [cytoplasmic vesicle membrane]
(R-HSA-1445121)
LNPEP [early endosome lumen]
(R-HSA-1236834)
LNPEP [cytosol]
(R-HSA-983098)
0.527
2
UniProt:P21796 VDAC1
4
VDAC1 [mitochondrial intermembrane space]
(R-HSA-1267960)
PolyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-6783079)
VDAC1 [mitochondrial outer membrane]
(R-HSA-1267988)
K48polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-5205624)
0.527
3
UniProt:Q7KZN9 COX15
1
COX15 [mitochondrial inner membrane]
(R-HSA-2995350)
0.527
2
UniProt:Q16288 NTRK3
6
NTRK3(32-495) [plasma membrane]
(R-HSA-9603541)
NTRK3(642-839) [cytosol]
(R-HSA-9603540)
NTRK3 [plasma membrane]
(R-HSA-6798240)
NTRK3(496-641) [mitochondrial outer membrane]
(R-HSA-9603557)
NTRK3(496-641) [cytosol]
(R-HSA-9603542)
p-5Y-NTRK3 [plasma membrane]
(R-HSA-9034718)
0.527
2
UniProt:Q9UHC6-1 CNTNAP2
0.499
2
UniProt:P41143 OPRD1
1
OPRD1 [plasma membrane]
(R-HSA-374265)
0.499
2
UniProt:P11607
2
ATP2A2 [platelet dense tubular network membrane]
(R-SSC-427903)
ATP2A2 [endoplasmic reticulum membrane]
(R-SSC-391962)
0.499
2
UniProt:P0C739 BNL2A
0.491
2
UniProt:Q9H3N1 TMX1
0.483
5
UniProt:P21860 ERBB3
0.483
3
UniProt:P30530 AXL
2
p-Y772,Y814-AXL [plasma membrane]
(R-HSA-5357460)
AXL [plasma membrane]
(R-HSA-197705)
0.483
2
UniProt:P52298 NCBP2
2
NCBP2 [nucleoplasm]
(R-HSA-51463)
NCBP2 [cytosol]
(R-HSA-162458)
0.483
2
UniProt:P30050 RPL12
1
RPL12 [cytosol]
(R-HSA-72408)
0.462
3
UniProt:A0A0F6B1Q8 A0A0F6B1Q8
0.462
2
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