Reactome | CANX [integral component of lumenal side of endoplasmic reticulum membrane]

CANX [integral component of lumenal side of endoplasmic reticulum membrane]

Stable Identifier

R-HSA-983091

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

integral component of lumenal side of endoplasmic reticulum membrane

Synonyms

Calnexin (CANX)

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P27824 CANX

Gene Names

CANX

Chain

signal peptide:1-20, chain:21-592

Reference Genes

BioGPS Gene:821 CANX

COSMIC (genes):CANX CANX

CTD Gene:821 CANX

dbSNP Gene:821 CANX

ENSEMBL:ENSG00000127022 CANX

ENSEMBL:ENSG00000283777 CANX

HGNC:1473 CANX

KEGG Gene (Homo sapiens):821 CANX

Monarch:821 CANX

NCBI Gene:821 CANX

OMIM:114217 CANX

UCSC:P27824 CANX

Reference Transcript

Other Identifiers

0002320095

0004780035

11727421_a_at

11727422_s_at

11727423_a_at

11727424_s_at

11727425_s_at

11727426_a_at

11741127_s_at

11745457_a_at

16993397

18670178

18670179

18670180

18670184

18670185

18670186

18670187

18670189

18670190

18670192

18670193

18670194

18670195

18670196

18670197

18670199

18670200

18670201

18670202

200068_PM_s_at

200068_s_at

208852_s_at

208853_s_at

238034_at

2844204

2844205

2844206

2844212

2844213

2844214

2844215

2844217

2844219

2844222

2844226

2844227

2844228

2844229

2844230

2844231

2844233

2844235

2844238

2844241

2844242

2844243

2844244

2844245

2844246

2844247

2844248

2844249

2844250

2844251

2844411

2844412

2844413

2844414

2844415

2844416

2844417

40125_at

53131_at

57826_at

7892514

7892972

7893103

7893270

7893272

7893345

7893632

7893641

7893642

7893880

7894074

7894674

7894687

7894725

7894878

7895017

7895276

7895283

7895334

7895475

7895547

7895693

7896050

7896136

7896308

7896387

7896430

8110522

A_23_P147185

A_24_P345993

A_33_P3325131

GE57598

GE85806

GO:0002376

GO:0002474

GO:0003674

GO:0003723

GO:0005509

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005783

GO:0005788

GO:0005789

GO:0005790

GO:0005791

GO:0005840

GO:0005886

GO:0006457

GO:0006810

GO:0006950

GO:0007165

GO:0007568

GO:0008150

GO:0009306

GO:0015031

GO:0016020

GO:0016021

GO:0016192

GO:0019886

GO:0030246

GO:0030424

GO:0030968

GO:0031410

GO:0032839

GO:0032991

GO:0034185

GO:0034975

GO:0035255

GO:0042470

GO:0043025

GO:0043167

GO:0043197

GO:0043226

GO:0044233

GO:0044322

GO:0046872

GO:0048488

GO:0051082

GO:0070062

GO:0070106

GO:0070757

GO:0071556

GO:0072583

GO:0098978

GO:0099055

GO:0099059

Hs.155560.0.S2_3p_a_at

Hs.43679.0.A1_3p_at

ILMN_1762825

ILMN_2401057

L10284_at

PH_hs_0009368

TC05001050.hg

g179831_3p_a_at

g306480_3p_a_at

Participant Of

hasMember

Chaperones calnexin/BiP [integral component of lumenal side of endoplasmic reticulum membrane]

Other forms of this molecule

CANX [endoplasmic reticulum lumen]

Inferred To

canx [integral component of lumenal side of endoplasmic reticulum membrane] (Danio rerio)

Canx [integral component of lumenal side of endoplasmic reticulum membrane] (Mus musculus)

Canx [integral component of lumenal side of endoplasmic reticulum membrane] (Rattus norvegicus)

cnxA [integral component of lumenal side of endoplasmic reticulum membrane] (Dictyostelium discoideum)

CNE1 [integral component of lumenal side of endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

CANX [integral component of lumenal side of endoplasmic reticulum membrane] (Bos taurus)

CANX [integral component of lumenal side of endoplasmic reticulum membrane] (Gallus gallus)

CANX [integral component of lumenal side of endoplasmic reticulum membrane] (Sus scrofa)

CANX [integral component of lumenal side of endoplasmic reticulum membrane] (Xenopus tropicalis)

cnx-1 [integral component of lumenal side of endoplasmic reticulum membrane] (Caenorhabditis elegans)

cal1 [integral component of lumenal side of endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

Cnx99A [integral component of lumenal side of endoplasmic reticulum membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001019820.1, NP_001737.1, XP_011532967.1

Target Pathogen

5b354852be737e166372e947

OpenTargets

ENSG00000127022

GeneCards

P27824

HPA

ENSG00000127022-CANX

Ensembl

ENSP00000491760, ENST00000639938, ENSP00000492372, ENST00000504734, ENSG00000283777, ENSG00000127022, ENST00000452673, ENST00000638706, ENST00000638425, ENSP00000424063, ENSP00000391646, ENST00000247461, ENSP00000492868, ENSP00000247461

PRO

P27824

HMDB Protein

HMDBP07535

Interactors (58)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43307 SSR1	1	SSR1 [endoplasmic reticulum membrane] (R-HSA-444588)	0.708	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.688	4
UniProt:P35610 SOAT1	1	SOAT1 [endoplasmic reticulum membrane] (R-HSA-8876490)	0.643	4
UniProt:P04578 env	7	Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211)	0.623	3
UniProt:P61619 SEC61A1	2	SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813) SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591)	0.597	4
UniProt:P04844 RPN2	1	RPN2 [endoplasmic reticulum membrane] (R-HSA-264937)	0.597	3
UniProt:O95477 ABCA1	11	ABCA1 R587W [plasma membrane] (R-HSA-5682197) ABCA1 Q537R [plasma membrane] (R-HSA-5682199) ABCA1 S1446L [plasma membrane] (R-HSA-5682195) ABCA1 C1417R [plasma membrane] (R-HSA-5682190) ABCA1 N935S [plasma membrane] (R-HSA-5682200) ABCA1 W590S [plasma membrane] (R-HSA-5682201) 4xPALM-C-p-2S-ABCA1 [plasma membrane] (R-HSA-5682069) ABCA1 [plasma membrane] (R-HSA-194209) 4xPALM-C-ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682085) 4xPALM-C-ABCA1 [plasma membrane] (R-HSA-5682091) ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682105)	0.576	8
UniProt:Q921T2 TOIP1			0.564	2
UniProt:Q7LFX5 CHST15	1	CHST15 [Golgi membrane] (R-HSA-1971543)	0.564	2
UniProt:Q9H3N1 TMX1			0.527	5
UniProt:P45880 VDAC2	2	PolyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-6783185) VDAC2 [mitochondrial outer membrane] (R-HSA-5696880)	0.527	2
UniProt:P48039 MTNR1A	1	MTNR1A [plasma membrane] (R-HSA-419316)	0.527	2
UniProt:P49286 MTNR1B	1	MTNR1B [plasma membrane] (R-HSA-419349)	0.527	2
UniProt:P16615 ATP2A2	2	ATP2A2 [endoplasmic reticulum membrane] (R-HSA-391962) ATP2A2 [platelet dense tubular network membrane] (R-HSA-427903)	0.527	2
UniProt:O94905 ERLIN2	3	ERLIN2(1-185):FGFR1(c.-88-822) fusion [plasma membrane] (R-HSA-8853148) ERLIN2 [endoplasmic reticulum membrane] (R-HSA-8866520) ERLIN2(1-185):p-8Y FGFR1(c.-88-822) fusion [plasma membrane] (R-HSA-8853122)	0.527	2
UniProt:Q9UIQ6 LNPEP	3	LNPEP [early endosome lumen] (R-HSA-1236834) LNPEP [cytoplasmic vesicle membrane] (R-HSA-1445121) LNPEP [cytosol] (R-HSA-983098)	0.527	2
UniProt:Q7KZN9 COX15	1	COX15 [mitochondrial inner membrane] (R-HSA-2995350)	0.527	2
UniProt:P21796 VDAC1	4	VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960)	0.527	3
UniProt:Q9UHC6-1 CNTNAP2			0.499	2
UniProt:P41143 OPRD1	1	OPRD1 [plasma membrane] (R-HSA-374265)	0.499	2
UniProt:P11607 AT2A2			0.499	2
UniProt:P0C739 BNL2A			0.491	2
UniProt:Q8NFQ8 TOIP2			0.462	2
UniProt:Q9NZ01 TECR	1	TECR [endoplasmic reticulum membrane] (R-HSA-548663)	0.462	2
UniProt:Q96GF1 RNF185	1	RNF185 [endoplasmic reticulum membrane] (R-HSA-8861819)	0.462	2
UniProt:P35606 COPB2	4	COPB2 [transport vesicle] (R-HSA-6808741) COPB2 [endoplasmic reticulum membrane] (R-HSA-6810957) COPB2 [cytosol] (R-HSA-199972) COPB2 [Golgi membrane] (R-HSA-6808739)	0.462	2
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [cytosol] (R-HSA-9609920) VAPA [plasma membrane] (R-HSA-6806269) VAPA [azurophil granule membrane] (R-HSA-6799364)	0.462	3
UniProt:Q9BSJ8 ESYT1	1	ESYT1 [endoplasmic reticulum membrane] (R-HSA-8857672)	0.462	3
UniProt:Q9Y2U8 LEMD3	1	LEMD3 [nuclear envelope] (R-HSA-2993886)	0.462	3
UniProt:P46977 STT3A	1	STT3A [endoplasmic reticulum membrane] (R-HSA-265023)	0.462	2
UniProt:P39656 DDOST	3	DDOST [plasma membrane] (R-HSA-879386) DDOST [endoplasmic reticulum membrane] (R-HSA-264963) DDOST [azurophil granule membrane] (R-HSA-6799145)	0.462	3
UniProt:P36542 ATP5F1C	1	ATP5C1 [mitochondrial matrix] (R-HSA-164577)	0.462	2
UniProt:O75787 ATP6AP2	3	ATP6AP2 [ficolin-1-rich granule membrane] (R-HSA-6800921) ATP6AP2 [tertiary granule membrane] (R-HSA-6799717) ATP6AP2 [plasma membrane] (R-HSA-2022356)	0.462	3
UniProt:Q8TCJ2 STT3B			0.462	2
UniProt:Q96AG4 LRC59			0.462	3
UniProt:Q86UP2 KTN1	3	KTN1 [endoplasmic reticulum lumen] (R-HSA-8956694) p-KTN1 [endoplasmic reticulum lumen] (R-HSA-8956968) KTN1 [endoplasmic reticulum membrane] (R-HSA-201604)	0.462	3
UniProt:O14967 CLGN			0.462	2
UniProt:P55011 SLC12A2	1	SLC12A2 [plasma membrane] (R-HSA-426146)	0.462	3
UniProt:P30050 RPL12	1	RPL12 [cytosol] (R-HSA-72408)	0.462	3
UniProt:Q99653 CHP1	1	p-CHP1 [plasma membrane] (R-HSA-5333747)	0.462	3
UniProt:O15173 PGRC2			0.462	3
UniProt:Q9P2E9 RRBP1			0.462	3
UniProt:Q5JTH9 RRP12			0.462	2
UniProt:Q9UBF2 COPG2	4	COPG2 [transport vesicle] (R-HSA-6808753) COPG2 [endoplasmic reticulum membrane] (R-HSA-6810962) COPG2 [cytosol] (R-HSA-6807747) COPG2 [Golgi membrane] (R-HSA-6808751)	0.462	2
UniProt:O00264 PGRMC1	2	PGRMC1 [specific granule membrane] (R-HSA-6799648) PGRMC1 [plasma membrane] (R-HSA-6806314)	0.462	2
UniProt:P42167 TMPO			0.462	2
UniProt:Q9Y4L1 HYOU1	3	HYOU1 [extracellular region] (R-HSA-3221939) HYOU1 [endocytic vesicle lumen] (R-HSA-3221924) HYOU1 [endoplasmic reticulum lumen] (R-HSA-535542)	0.462	3
UniProt:Q8N766 EMC1			0.462	3
UniProt:P27824 CANX	2	CANX [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.462	4
UniProt:P04843 RPN1	1	RPN1 [endoplasmic reticulum membrane] (R-HSA-264994)	0.462	2
UniProt:Q15904 ATP6AP1	1	ATP6AP1 [endosome membrane] (R-HSA-5215981)	0.462	3
UniProt:P05556 ITGB1	2	ITGB1 [endosome membrane] (R-HSA-9611157) ITGB1 [plasma membrane] (R-HSA-57596)	0.462	2
UniProt:Q14739 LBR	2	LBR [nuclear envelope] (R-HSA-194637) p-S71,S86-LBR [nuclear envelope] (R-HSA-9624811)	0.462	3
UniProt:P35613 BSG	2	BSG [Golgi membrane] (R-HSA-204478) BSG [plasma membrane] (R-HSA-197673)	0.462	3
UniProt:Q07065 CKAP4	7	PALM-C100-CKAP4 [plasma membrane] (R-HSA-5686280) PALM-C100-CKAP4 [lamellar body] (R-HSA-5686285) CKAP4 [azurophil granule membrane] (R-HSA-6799559) CKAP4 [plasma membrane] (R-HSA-5686306) CKAP4 [specific granule membrane] (R-HSA-6799552) p-CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956926) CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956737)	0.462	2
UniProt:Q9H2J7 SLC6A15	1	SLC6A15 [plasma membrane] (R-HSA-352060)	0.462	2
UniProt:Q9NZC7 WWOX	1	WWOX [cytosol] (R-HSA-1253335)	0.462	2
UniProt:Q9Y5M8 SRPRB	1	SRPRB [endoplasmic reticulum membrane] (R-HSA-265002)	0.462	3