Reactome | CANX [lumenal side of endoplasmic reticulum membrane]

CANX [lumenal side of endoplasmic reticulum membrane]

Stable Identifier

R-HSA-983091

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lumenal side of endoplasmic reticulum membrane

Synonyms

Calnexin (CANX)

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P27824 CANX

Gene Names

CANX

Chain

signal peptide:1-20, chain:21-592

Reference Genes

BioGPS Gene:821 P278242

COSMIC (genes):CANX CANX

CTD Gene:821 CANX

dbSNP Gene:821 CANX

ENSEMBL:ENSG00000127022 CANX

HGNC:1473 P278242

KEGG:hsa:821 P278242

Monarch:821 P278242

NCBI Gene:821 P278242

OMIM:114217 P278242

UCSC:P27824 P278242

Reference Transcript

Participates

as a member of

Chaperones calnexin/BiP [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

CANX [endoplasmic reticulum lumen]

CANX [endoplasmic reticulum membrane]

Inferred To

CNE1 [lumenal side of endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

Cnx99A [lumenal side of endoplasmic reticulum membrane] (Drosophila melanogaster)

canx [lumenal side of endoplasmic reticulum membrane] (Danio rerio)

canx [lumenal side of endoplasmic reticulum membrane] (Xenopus tropicalis)

CANX [lumenal side of endoplasmic reticulum membrane] (Bos taurus)

CANX [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)

CANX [lumenal side of endoplasmic reticulum membrane] (Gallus gallus)

CANX [lumenal side of endoplasmic reticulum membrane] (Sus scrofa)

cnxA [lumenal side of endoplasmic reticulum membrane] (Dictyostelium discoideum)

Canx [lumenal side of endoplasmic reticulum membrane] (Mus musculus)

Canx [lumenal side of endoplasmic reticulum membrane] (Rattus norvegicus)

cal1 [lumenal side of endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

cnx-1 [lumenal side of endoplasmic reticulum membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001350926.1, XP_054209564.1, NP_001350930.1, NP_001737.1, NP_001350923.1, NP_001350929.1, XP_011532967.1, XP_047273748.1, XP_054187987.1, XP_054187988.1, NP_001019820.1, NP_001350925.1

OpenTargets

ENSG00000127022

ENSEMBL

ENSP00000505526, ENSP00000505129, ENSP00000247461, ENSP00000505202, ENSG00000283777, ENSP00000506051, ENST00000681733, ENST00000681476, ENSP00000391646, ENST00000638425, ENST00000681712, ENST00000681072, ENST00000681674, ENSP00000505960, ENST00000680042, ENST00000680006, ENSP00000506078, ENSP00000492868, ENSP00000492372, ENST00000513246, ENSP00000424063, ENST00000681903, ENST00000680618, ENSP00000421434, ENSP00000491760, ENST00000638706, ENST00000639938, ENSP00000506509, ENSP00000424745, ENSP00000506021, ENSP00000506583, ENSP00000506568, ENSP00000421813, ENST00000504734, ENSP00000506061, ENST00000681168, ENST00000680092, ENST00000452673, ENST00000506654, ENST00000680013, ENSP00000506003, ENST00000509563, ENST00000247461, ENSG00000127022, ENST00000502296, ENSP00000505013, ENST00000680827, ENSP00000426555

GeneCards

CANX

HPA

ENSG00000127022-CANX

PRO

P27824

Pharos - Targets

P27824

GlyGen

P27824

HMDB Protein

HMDBP07535

Interactors (174)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.888	27
UniProt:P43307 SSR1	1	SSR1 [endoplasmic reticulum membrane] (R-HSA-444588)	0.773	7
UniProt:Q9H5K3 POMK	1	POMK [endoplasmic reticulum membrane] (R-HSA-8879120)	0.725	5
UniProt:P61619 SEC61A1	2	SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591) SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813)	0.69	5
UniProt:O00115 DNASE2	2	DNASE2 [Golgi lumen] (R-HSA-434322) DNASE2 [lysosomal lumen] (R-HSA-429822)	0.688	3
UniProt:P04844 RPN2	1	RPN2 [endoplasmic reticulum membrane] (R-HSA-264937)	0.671	5
UniProt:Q8N766 EMC1			0.671	5
UniProt:Q7LFX5 CHST15	1	CHST15 [Golgi membrane] (R-HSA-1971543)	0.669	3
UniProt:Q8TCJ2 STT3B	1	STT3B [endoplasmic reticulum membrane] (R-HSA-264930)	0.644	5
UniProt:Q14703 MBTPS1	4	MBTPS1 [Golgi membrane] (R-HSA-381108) MBTPS1 [endoplasmic reticulum membrane] (R-HSA-6797334) p-MBTPS1 [endoplasmic reticulum lumen] (R-HSA-8956924) MBTPS1 [endoplasmic reticulum lumen] (R-HSA-8956733)	0.643	3
UniProt:Q8NBL1 POGLUT1	1	POGLUT1 [endoplasmic reticulum lumen] (R-HSA-1464796)	0.643	5
UniProt:P16615 ATP2A2	2	ATP2A2 [endoplasmic reticulum membrane] (R-HSA-391962) ATP2A2 [platelet dense tubular network membrane] (R-HSA-427903)	0.643	3
UniProt:Q8IZF4 AGRG5			0.643	3
UniProt:P54709 ATP1B3	1	ATP1B3 [plasma membrane] (R-HSA-375073)	0.643	3
UniProt:Q4G148 GXLT1			0.643	4
UniProt:Q7L1S5 CHST9			0.643	3
UniProt:Q9UIQ6 LNPEP	3	LNPEP [cytosol] (R-HSA-983098) LNPEP [early endosome lumen] (R-HSA-1236834) LNPEP [cytoplasmic vesicle membrane] (R-HSA-1445121)	0.643	3
UniProt:O94905 ERLIN2	3	ERLIN2 [endoplasmic reticulum membrane] (R-HSA-8866520) EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-p-8Y-FGFR1(1-822) [plasma membrane] (R-HSA-8853122) EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-FGFR1(1-822) [plasma membrane] (R-HSA-8853148)	0.643	3
UniProt:Q9H741 SPRNG			0.643	3
UniProt:Q9H2A9 CHST8	1	CHST8 [Golgi membrane] (R-HSA-6786024)	0.643	4
UniProt:Q8NCH0 CHST14	9	CHST14 [Golgi membrane] (R-HSA-1971536) CHST14 L137Q [Golgi membrane] (R-HSA-5649488) CHST14 P281L [Golgi membrane] (R-HSA-3636880) CHST14 Y293C [Golgi membrane] (R-HSA-3636927) CHST14 R213P [Golgi membrane] (R-HSA-3636894) CHST14 V49* [Golgi membrane] (R-HSA-3636926) CHST14 C289S [Golgi membrane] (R-HSA-3636925) CHST14 R135G [Golgi membrane] (R-HSA-3636924) CHST14 K69* [Golgi membrane] (R-HSA-3636891)	0.643	3
UniProt:Q9H1A3 METL9			0.643	3
UniProt:Q9BTY2 FUCA2	4	FUCA2 [extracellular region] (R-HSA-6806227) FUCA2 [azurophil granule lumen] (R-HSA-6798772) p-FUCA2 [endoplasmic reticulum lumen] (R-HSA-8957005) FUCA2 [endoplasmic reticulum lumen] (R-HSA-8956727)	0.643	3
UniProt:P04578 env	7	Surface protein gp120 [viral envelope] (R-HIV-171211) ENV [viral envelope] (R-HIV-173439) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269)	0.623	3
UniProt:P35610 SOAT1	1	SOAT1 [endoplasmic reticulum membrane] (R-HSA-8876490)	0.615	4
UniProt:Q9H3N1 TMX1			0.615	6
UniProt:O95477 ABCA1	11	ABCA1 [plasma membrane] (R-HSA-194209) 4xPALM-C-p-2S-ABCA1 [plasma membrane] (R-HSA-5682069) 4xPALM-C-ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682085) 4xPALM-C-ABCA1 [plasma membrane] (R-HSA-5682091) ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682105) ABCA1 Q537R [plasma membrane] (R-HSA-5682199) ABCA1 R587W [plasma membrane] (R-HSA-5682197) ABCA1 S1446L [plasma membrane] (R-HSA-5682195) ABCA1 C1417R [plasma membrane] (R-HSA-5682190) ABCA1 N935S [plasma membrane] (R-HSA-5682200) ABCA1 W590S [plasma membrane] (R-HSA-5682201)	0.576	8
UniProt:Q9NZ01 TECR	1	TECR [endoplasmic reticulum membrane] (R-HSA-548663)	0.569	3
UniProt:P08069 IGF1R	3	IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.569	3
UniProt:P35606 COPB2	4	COPB2 [endoplasmic reticulum membrane] (R-HSA-6810957) COPB2 [Golgi membrane] (R-HSA-6808739) COPB2 [transport vesicle] (R-HSA-6808741) COPB2 [cytosol] (R-HSA-199972)	0.569	4
UniProt:P46977 STT3A	1	STT3A [endoplasmic reticulum membrane] (R-HSA-265023)	0.569	3
UniProt:P39656 DDOST	3	DDOST [azurophil granule membrane] (R-HSA-6799145) DDOST [plasma membrane] (R-HSA-879386) DDOST [endoplasmic reticulum membrane] (R-HSA-264963)	0.569	5
UniProt:Q96AG4 LRC59			0.569	4
UniProt:O14967 CLGN			0.569	3
UniProt:O00264 PGRMC1	2	PGRMC1 [plasma membrane] (R-HSA-6806314) PGRMC1 [specific granule membrane] (R-HSA-6799648)	0.569	4
UniProt:Q9H2J7 SLC6A15	1	SLC6A15 [plasma membrane] (R-HSA-352060)	0.569	3
UniProt:Q14739 LBR	4	LBR [nuclear envelope] (R-HSA-194637) p-S71,S86-LBR [nuclear envelope] (R-HSA-9624811) LBR [endoplasmic reticulum membrane] (R-HSA-9714334) LBR [endosome membrane] (R-HSA-9715094)	0.569	4
UniProt:P04843 RPN1	1	RPN1 [endoplasmic reticulum membrane] (R-HSA-264994)	0.569	4
UniProt:Q8NFQ8 TOIP2			0.569	3
UniProt:Q96GF1 RNF185	1	RNF185 [endoplasmic reticulum membrane] (R-HSA-8861819)	0.569	3
UniProt:Q07065 CKAP4	7	CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956737) p-CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956926) CKAP4 [specific granule membrane] (R-HSA-6799552) CKAP4 [plasma membrane] (R-HSA-5686306) CKAP4 [azurophil granule membrane] (R-HSA-6799559) PALM-C100-CKAP4 [plasma membrane] (R-HSA-5686280) PALM-C100-CKAP4 [lamellar body] (R-HSA-5686285)	0.569	3
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [cytosol] (R-HSA-9609920)	0.569	5
UniProt:O75787 ATP6AP2	3	ATP6AP2 [plasma membrane] (R-HSA-2022356) ATP6AP2 [tertiary granule membrane] (R-HSA-6799717) ATP6AP2 [ficolin-1-rich granule membrane] (R-HSA-6800921)	0.569	4
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.569	3
UniProt:P55011 SLC12A2	1	SLC12A2 [plasma membrane] (R-HSA-426146)	0.569	4
UniProt:Q9UBF2 COPG2	4	COPG2 [endoplasmic reticulum membrane] (R-HSA-6810962) COPG2 [Golgi membrane] (R-HSA-6808751) COPG2 [transport vesicle] (R-HSA-6808753) COPG2 [cytosol] (R-HSA-6807747)	0.569	3
UniProt:Q15904 ATP6AP1	2	ATP6AP1 [endosome membrane] (R-HSA-5215981) ATP6AP1 [endoplasmic reticulum membrane] (R-HSA-9714332)	0.569	4
UniProt:O15173 PGRMC2	4	PGRMC2 [nuclear envelope] (R-HSA-9707674) PGRMC2 [nucleoplasm] (R-HSA-9707859) PGRMC2 [endoplasmic reticulum membrane] (R-HSA-9714349) PGRMC2 [endosome membrane] (R-HSA-9715090)	0.569	4
UniProt:Q9Y4L1 HYOU1	3	HYOU1 [extracellular region] (R-HSA-3221939) HYOU1 [endocytic vesicle lumen] (R-HSA-3221924) HYOU1 [endoplasmic reticulum lumen] (R-HSA-535542)	0.569	4
UniProt:Q9NZC7 WWOX	1	WWOX [cytosol] (R-HSA-1253335)	0.569	3
UniProt:Q9Y5M8 SRPRB	1	SRPRB [endoplasmic reticulum membrane] (R-HSA-265002)	0.569	4
UniProt:P35613 BSG	2	BSG [plasma membrane] (R-HSA-197673) BSG [Golgi membrane] (R-HSA-204478)	0.569	4
UniProt:P05556 ITGB1	2	ITGB1 [plasma membrane] (R-HSA-57596) ITGB1 [endosome membrane] (R-HSA-9611157)	0.569	3
UniProt:Q921T2	1	Tor1aip1 [cytosol] (R-MMU-9715083)	0.564	2
UniProt:P00387 CYB5R3	3	CYB5R3(27-301) [azurophil granule lumen] (R-HSA-6799217) CYB5R3(27-301) [extracellular region] (R-HSA-6806205) MyrG-CYB5R3(2-301) [mitochondrial outer membrane] (R-HSA-198771)	0.564	2
UniProt:P29622 SERPINA4	3	SERPINA4 [extracellular region] (R-HSA-8848886) SERPINA4 [platelet dense granule lumen] (R-HSA-8848911) SERPINA4 [zymogen granule] (R-HSA-9923889)	0.564	2
UniProt:Q8NBM8 PCYOX1L	2	PCYOX1L [extracellular region] (R-HSA-8862953) PCYOX1L [platelet alpha granule lumen] (R-HSA-8862980)	0.527	2
UniProt:Q9Y2A9 B3GNT3	1	B3GNT3 [Golgi membrane] (R-HSA-916819)	0.527	3
UniProt:P36897 TGFBR1	13	p-4S,T185,T186-TGFBR1 [plasma membrane] (R-HSA-170849) TGFBR1 [plasma membrane] (R-HSA-170839) TGFBR1 P83S [plasma membrane] (R-HSA-3656326) TGFBR1 P83L [plasma membrane] (R-HSA-3656341) TGFBR1 N45S [plasma membrane] (R-HSA-3656348) TGFBR1 C41Y [plasma membrane] (R-HSA-3656328) TGFBR1 G52R [plasma membrane] (R-HSA-3656368) p-4S,T185,T186-TGFBR1 D269_Q324del [plasma membrane] (R-HSA-3656509) p-4S,T185,T186-TGFBR1 R414* [plasma membrane] (R-HSA-3656508) p-4S,T185,T186-TGFBR1 L354Nfs4 [plasma membrane] (R-HSA-3656506) p-4S,T185,T186-TGFBR1 P327Qfs8 [plasma membrane] (R-HSA-3656505) p-4S,T185,T186-TGFBR1 W242* [plasma membrane] (R-HSA-3656504) Ub-TGFBR1 [plasma membrane] (R-HSA-8869461)	0.527	2
UniProt:Q15165 PON2	1	PON2 [extracellular region] (R-HSA-8932636)	0.527	2
UniProt:O60512 B4GALT3	1	B4GALT3 [Golgi membrane] (R-HSA-975922)	0.527	2
UniProt:P42892 ECE1	1	ECE1 [plasma membrane] (R-HSA-8876866)	0.527	2
UniProt:P06280 GLA	3	GLA [lysosomal lumen] (R-HSA-1605763) GLA [azurophil granule lumen] (R-HSA-6798777) GLA [extracellular region] (R-HSA-6806179)	0.527	2
UniProt:Q8WTV0 SCARB1			0.527	2
UniProt:Q6UWY0 ARSK	2	OxA-ARSK [endoplasmic reticulum lumen] (R-HSA-1614364) ARSK [endoplasmic reticulum lumen] (R-HSA-1609684)	0.527	3
UniProt:Q9UNL2 SSR3	1	SSR3 [endoplasmic reticulum membrane] (R-HSA-264973)	0.527	2
UniProt:P45880 VDAC2	6	p-S65-Ub:VDAC2 [mitochondrial outer membrane] (R-HSA-9834982) K63polyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-9843314) K48polyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-9843321) Ub-VDAC2 [mitochondrial outer membrane] (R-HSA-9835025) VDAC2 [mitochondrial outer membrane] (R-HSA-5696880) PolyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-6783185)	0.527	2
UniProt:Q9UKF2 ADAM30	1	ADAM30 [plasma membrane] (R-HSA-1297326)	0.527	2
UniProt:Q14982 OPCML	2	GPI-OPCML [plasma membrane] (R-HSA-8940828) cleaved GPI-OPCML [extracellular region] (R-HSA-8941075)	0.527	2
UniProt:P21796 VDAC1	7	p-S65-Ub:VDAC1 [mitochondrial outer membrane] (R-HSA-9834991) K63polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-9834037) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) Ub-VDAC1 [mitochondrial outer membrane] (R-HSA-9834989) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079)	0.527	3
UniProt:Q6ZQN7 SLCO4C1	3	SLCO4C1 [azurophil granule membrane] (R-HSA-6799239) SLCO4C1 [plasma membrane] (R-HSA-879598) SLCO4C1 [specific granule membrane] (R-HSA-6800901)	0.527	2
UniProt:Q9Y320 TMX2			0.527	3
UniProt:P10253 GAA	8	GAA (123-?) [lysosomal lumen] (R-HSA-5357560) GAA (204-?) [lysosomal lumen] (R-HSA-5357544) GAA [azurophil granule membrane] (R-HSA-6800877) GAA [plasma membrane] (R-HSA-6801041) GAA [tertiary granule membrane] (R-HSA-6801021) GAA [ficolin-1-rich granule membrane] (R-HSA-6800913) GAA M318T [lysosomal lumen] (R-HSA-5357607) GAA E521K [lysosomal lumen] (R-HSA-5357598)	0.527	2
UniProt:P08195 SLC3A2	1	SLC3A2 [plasma membrane] (R-HSA-352179)	0.527	2
UniProt:P40126 DCT	1	DCT [melanosome membrane] (R-HSA-5662685)	0.527	3
UniProt:Q8IWF2 FXRD2			0.527	3
UniProt:Q9NV96 TMEM30A	3	TMEM30A [specific granule membrane] (R-HSA-6799526) TMEM30A [plasma membrane] (R-HSA-6806278) TMEM30A [azurophil granule membrane] (R-HSA-6799504)	0.527	2
UniProt:Q96EG1 ARSG	2	ARSG [endoplasmic reticulum lumen] (R-HSA-1614361) OxA-ARSG [endoplasmic reticulum lumen] (R-HSA-1614304)	0.527	2
UniProt:P54802 NAGLU	5	NAGLU R674C [lysosomal lumen] (R-HSA-2219558) NAGLU R674H [lysosomal lumen] (R-HSA-2219557) NAGLU R626* [lysosomal lumen] (R-HSA-2219568) NAGLU R297* [lysosomal lumen] (R-HSA-2219553) NAGLU(59-743) [lysosomal lumen] (R-HSA-1678772)	0.527	2
UniProt:P51654 GPC3	20	HS(4)-GPC3 [plasma membrane] (R-HSA-2076637) HS(6)-GPC3 [plasma membrane] (R-HSA-2076656) HS(2)-GPC3 [plasma membrane] (R-HSA-2076622) HS(1)-GPC3 [plasma membrane] (R-HSA-2076660) HS(3)-GPC3 [plasma membrane] (R-HSA-2076650) HS(5)-GPC3 [plasma membrane] (R-HSA-2076669) GPC3 [endoplasmic reticulum lumen] (R-HSA-8956735) p-GPC3 [endoplasmic reticulum lumen] (R-HSA-8956894) GPC3(25-?) [Golgi lumen] (R-HSA-2054100) XylS-GPC3(25-?) [Golgi lumen] (R-HSA-2064021) Gal-Xyl-GPC3 [Golgi lumen] (R-HSA-2064202) Gal-Gal-Xyl-GPC3 [Golgi lumen] (R-HSA-2063987) GlcA-Gal-Gal-Xyl-GPC3 [Golgi lumen] (R-HSA-2064012) Heparan-GPC3 [Golgi lumen] (R-HSA-2076477) Heparan(1)-GPC3 [Golgi lumen] (R-HSA-2076279) Heparan(2)-GPC3 [Golgi lumen] (R-HSA-2076409) Heparan(3)-GPC3 [Golgi lumen] (R-HSA-2076311) Heparan(4)-GPC3 [Golgi lumen] (R-HSA-2076377) HS(1)-GPC3 [Golgi lumen] (R-HSA-2076471) HS(2)-GPC3 [Golgi lumen] (R-HSA-2076413)	0.527	3
UniProt:Q9Y5X9 LIPG	1	LIPG [extracellular region] (R-HSA-6789318)	0.527	2
UniProt:Q86YC3 LRC33			0.527	2
UniProt:Q6PK18 OGFD3			0.527	3
UniProt:Q9NPC4 A4GALT	1	A4GALT [Golgi membrane] (R-HSA-9846476)	0.527	3
UniProt:O75556 SG2A1			0.527	2
UniProt:Q8NE01 CNNM3			0.527	2
UniProt:Q92581 SLC9A6	6	SLC9A6 [early endosome membrane] (R-HSA-425984) SLC9A6 H171fs60 [early endosome membrane] (R-HSA-5661079) SLC9A6 338-340del [early endosome membrane] (R-HSA-5661042) SLC9A6 R468 [early endosome membrane] (R-HSA-5661072) SLC9A6 E547* [early endosome membrane] (R-HSA-5661037) SLC9A6 E255_S256del [early endosome membrane] (R-HSA-5661066)	0.527	2
UniProt:Q8TCT7 SPPL2B	1	SPPL2B [plasma membrane] (R-HSA-8863116)	0.527	2
UniProt:Q96MM7 HS6ST2	1	HS6ST2 [Golgi membrane] (R-HSA-2076353)	0.527	2
UniProt:O95672 ECEL1			0.527	4
UniProt:P49286 MTNR1B	1	MTNR1B [plasma membrane] (R-HSA-419349)	0.527	2
UniProt:Q9UKU6 TRHDE			0.527	2
UniProt:Q8N5K1 CISD2			0.527	2
UniProt:P18507 GABRG2	1	GABRG2 [plasma membrane] (R-HSA-975350)	0.527	2
UniProt:Q17R55 F187B			0.527	2
UniProt:P04062 GBA1	2	GBA1 [lysosomal membrane] (R-HSA-1605775) Unfolded GBA [cytosol] (R-HSA-6813790)	0.527	2
UniProt:Q99999 GAL3ST1	1	GAL3ST1 [Golgi membrane] (R-HSA-1631586)	0.527	3
UniProt:Q3KNT9 TMM95			0.527	2
UniProt:P10909 CLU	4	CLU(23-449) [extracellular region] (R-HSA-349732) CLU(23-449) [platelet alpha granule lumen] (R-HSA-349733) CLU(228-449) [extracellular region] (R-HSA-6810626) CLU(23-227) [extracellular region] (R-HSA-6810660)	0.527	2
UniProt:Q86T26 TM11B			0.527	2
UniProt:Q9UKJ8 ADAM21	1	ADAM21 [plasma membrane] (R-HSA-1297340)	0.527	3
UniProt:P48039 MTNR1A	1	MTNR1A [plasma membrane] (R-HSA-419316)	0.527	2
UniProt:O14656 TOR1A	1	TOR1A [cytosol] (R-HSA-8862858)	0.527	3
UniProt:Q9C0B6 BRNP2			0.527	3
UniProt:Q16842 ST3GAL2	1	ST3GAL2 [Golgi membrane] (R-HSA-981482)	0.527	2
UniProt:Q9H0U3 MAGT1	3	MAGT1 [plasma membrane] (R-HSA-4836523) MAGT1 [azurophil granule membrane] (R-HSA-6799208) MAGT1 [endoplasmic reticulum membrane] (R-HSA-9932187)	0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322)	0.527	2
UniProt:P51172 SCNN1D	1	SCNN1D [plasma membrane] (R-HSA-2671902)	0.527	2
UniProt:Q96JJ7 TMX3	2	TMX3 [plasma membrane] (R-HSA-8848896) TMX3 [platelet alpha granule membrane] (R-HSA-8848889)	0.527	3
UniProt:Q92820 GGH	4	GGH [tertiary granule lumen] (R-HSA-6800911) GGH [specific granule lumen] (R-HSA-6799639) GGH [extracellular region] (R-HSA-6799679) GGH [azurophil granule lumen] (R-HSA-6800950)	0.527	2
UniProt:Q92542 NCSTN	3	NCSTN [plasma membrane] (R-HSA-2534241) NCSTN [azurophil granule membrane] (R-HSA-6799220) NCSTN [endosome membrane] (R-HSA-9010085)	0.527	2
UniProt:Q03518 TAP1	3	TAP1 [endoplasmic reticulum membrane] (R-HSA-947474) TAP1 [phagocytic vesicle membrane] (R-HSA-1236845) TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863953)	0.527	2
UniProt:Q86WK7 AMGO3			0.527	2
UniProt:O75477 ERLIN1	1	ERLIN1 [endoplasmic reticulum membrane] (R-HSA-8866518)	0.527	2
UniProt:Q9GZX3 CHST6	9	CHST6 [Golgi membrane] (R-HSA-1971537) CHST6 C102G [Golgi membrane] (R-HSA-3656470) CHST6 L200R [Golgi membrane] (R-HSA-3656454) CHST6 D203E [Golgi membrane] (R-HSA-3656437) CHST6 E274K [Golgi membrane] (R-HSA-3656420) CHST6 Y110C [Golgi membrane] (R-HSA-3656419) CHST6 K174R [Golgi membrane] (R-HSA-3656480) CHST6 L276P [Golgi membrane] (R-HSA-3656477) CHST6 R211W [Golgi membrane] (R-HSA-3656457)	0.527	2
UniProt:O75354 ENTPD6	1	ENTPD6 (77-484) [extracellular region] (R-HSA-8851464)	0.527	2
UniProt:P15812 CD1E			0.527	2
UniProt:Q9HB40 RISC			0.527	2
UniProt:P29016 CD1B	1	CD1B [plasma membrane] (R-HSA-197793)	0.527	3
UniProt:Q7KZN9 COX15	1	COX15 [mitochondrial inner membrane] (R-HSA-2995350)	0.527	2
UniProt:Q13724 MOGS	3	MOGS F652L [endoplasmic reticulum membrane] (R-HSA-4839779) MOGS R486T [endoplasmic reticulum membrane] (R-HSA-4839818) MOGS [endoplasmic reticulum membrane] (R-HSA-532676)	0.527	2
UniProt:Q13443 ADAM9	1	ADAM9 [plasma membrane] (R-HSA-708336)	0.527	2
UniProt:Q9H4B8 DPEP3			0.527	2
UniProt:Q08380 LGALS3BP	2	LGALS3BP [extracellular region] (R-HSA-8848882) LGALS3BP [platelet dense granule lumen] (R-HSA-8848916)	0.527	2
UniProt:Q8WXQ8 CBPA5			0.527	2
UniProt:P01019 AGT	7	AGT(25-32) [extracellular region] (R-HSA-374187) AGT(25-34) [extracellular region] (R-HSA-2022346) AGT [extracellular region] (R-HSA-1998759) AGT(25-31) [extracellular region] (R-HSA-2022351) AGT(25-33) [extracellular region] (R-HSA-2022348) AGT(26-32) [extracellular region] (R-HSA-2022354) AGT(27-32) [extracellular region] (R-HSA-2022355)	0.527	2
UniProt:Q13444 ADAM15	1	ADAM15 [plasma membrane] (R-HSA-708329)	0.527	2
UniProt:P30101 PDIA3	3	PDIA3 [recycling endosome membrane] (R-HSA-8863849) PDIA3 [phagocytic vesicle] (R-HSA-1236870) PDIA3 [endoplasmic reticulum lumen] (R-HSA-901028)	0.527	2
UniProt:Q6PIU2 NCEH1	1	NCEH1 [endoplasmic reticulum membrane] (R-HSA-6813685)	0.527	2
UniProt:Q9Y2B1 RXYLT1	1	RXYLT1 [Golgi membrane] (R-HSA-9940790)	0.527	2
UniProt:Q9Y2C2 UST	1	UST [Golgi membrane] (R-HSA-2022058)	0.527	3
UniProt:P56704 WNT3A	10	N4GlycoAsn-PalmS WNT3A [plasma membrane] (R-HSA-3247807) N4GlycoAsn-PalmS WNT3A [extracellular region] (R-HSA-3247784) N4GlycoAsn-PalmS WNT3A [Golgi lumen] (R-HSA-3247832) N4GlycoAsn-PalmS WNT3A [endoplasmic reticulum lumen] (R-HSA-3238344) N4GlycoAsn-WNT3A [endoplasmic reticulum lumen] (R-HSA-3238231) WNT3A [endoplasmic reticulum lumen] (R-HSA-3238292) N4GlycoAsn-PalmS WNT3A [early endosome membrane] (R-HSA-5368483) N4GlycoAsn-PalmS WNT3A [endocytic vesicle membrane] (R-HSA-3781944) N4GlycoAsn-PalmS WNT3A [extracellular exosome] (R-HSA-3781968) WNT3A [extracellular region] (R-HSA-201710)	0.527	3
UniProt:Q16880 UGT8	1	UGT8 [endoplasmic reticulum membrane] (R-HSA-9844570)	0.527	2
UniProt:Q6UWB1 IL27RA	4	IL27RA [plasma membrane] (R-HSA-448478) p-Y611-IL27RA [plasma membrane] (R-HSA-8950330) sIL27RA [extracellular region] (R-HSA-8950454) sIL27RA [cytoplasm] (R-HSA-8950653)	0.527	2
UniProt:Q16288 NTRK3	6	p-5Y-NTRK3 [plasma membrane] (R-HSA-9034718) NTRK3 [plasma membrane] (R-HSA-6798240) NTRK3(496-641) [cytosol] (R-HSA-9603542) NTRK3(496-641) [mitochondrial outer membrane] (R-HSA-9603557) NTRK3(642-839) [cytosol] (R-HSA-9603540) NTRK3(32-495) [plasma membrane] (R-HSA-9603541)	0.527	2
UniProt:Q9UHC6-1 CNTNAP2			0.499	2
UniProt:P41143 OPRD1	1	OPRD1 [plasma membrane] (R-HSA-374265)	0.499	2
UniProt:P11607	2	ATP2A2 [platelet dense tubular network membrane] (R-SSC-427903) ATP2A2 [endoplasmic reticulum membrane] (R-SSC-391962)	0.499	2
UniProt:P0C739 BNL2A			0.491	2
UniProt:O75976 CPD	3	CPD [Golgi membrane] (R-HSA-432675) CPD [cytoplasmic vesicle membrane] (R-HSA-432671) CPD [plasma membrane] (R-HSA-9715182)	0.483	2
UniProt:Q86Y07 VRK2	2	VRK2 [endoplasmic reticulum membrane] (R-HSA-9714457) VRK2 [mitochondrial outer membrane] (R-HSA-9715102)	0.483	3
UniProt:P51648 ALDH3A2	1	ALDH3A2 [cytosol] (R-HSA-9715204)	0.483	3
UniProt:O14579 COPE	4	COPE [endoplasmic reticulum membrane] (R-HSA-6810959) COPE [Golgi membrane] (R-HSA-6808743) COPE [transport vesicle] (R-HSA-6808745) COPE [cytosol] (R-HSA-199969)	0.483	3
UniProt:P52298 NCBP2	2	NCBP2 [nucleoplasm] (R-HSA-51463) NCBP2 [cytosol] (R-HSA-162458)	0.483	2
UniProt:O95292 VAPB	2	VAPB [endoplasmic reticulum membrane] (R-HSA-429718) VAPB [Golgi membrane] (R-HSA-9715115)	0.483	3
UniProt:O95573 ACSL3	2	ACSL3 [mitochondrial outer membrane] (R-HSA-9632656) ACSL3 [endoplasmic reticulum membrane] (R-HSA-548787)	0.483	3
UniProt:Q9P0I2 EMC3	1	EMC3 [endoplasmic reticulum membrane] (R-HSA-9714347)	0.483	3
UniProt:Q9H8Y8 GORASP2	2	GORASP2 [Golgi membrane] (R-HSA-2422385) p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965)	0.483	2
UniProt:O43865 AHCYL1	1	AHCYL1 [endoplasmic reticulum membrane] (R-HSA-5215973)	0.483	2
UniProt:Q6ZNB6 NFXL1			0.483	2
UniProt:P30530 AXL	2	p-Y779,Y821-AXL [plasma membrane] (R-HSA-5357460) AXL [plasma membrane] (R-HSA-197705)	0.483	2
UniProt:Q9BTX1 NDC1	1	NDC1 [nuclear envelope] (R-HSA-6805183)	0.483	3
UniProt:O43402 EMC8			0.483	2
UniProt:Q96A57 TM230			0.483	2
UniProt:Q9Y679 AUP1			0.483	2
UniProt:Q6NUS6 TCTN3	1	TCTN3 [ciliary membrane] (R-HSA-5626662)	0.483	3
UniProt:Q9NPA0 EMC7			0.483	3
UniProt:P11717 IGF2R	7	IGF2R [secretory granule membrane] (R-HSA-6803320) IGF2R [plasma membrane] (R-HSA-6806532) IGF2R [trans-Golgi network membrane] (R-HSA-6814608) IGF2R [transport vesicle] (R-HSA-6814609) IGF2R [cytoplasmic vesicle membrane] (R-HSA-434213) IGF2R [Golgi membrane] (R-HSA-434345) IGF2R [clathrin-coated endocytic vesicle membrane] (R-HSA-8869091)	0.483	2
UniProt:Q96S66 CLCC1			0.483	3
UniProt:Q5J8M3 EMC4			0.483	2
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.483	3
UniProt:P21860 ERBB3			0.483	3
UniProt:Q15005 SPCS2	1	SPCS2 [endoplasmic reticulum membrane] (R-HSA-264996)	0.483	2
UniProt:Q13586 STIM1	1	STIM1 [endoplasmic reticulum membrane] (R-HSA-434675)	0.483	3
UniProt:P61009 SPCS3	1	SPCS3 [endoplasmic reticulum membrane] (R-HSA-264916)	0.483	2
UniProt:Q96A33 CCD47			0.483	4
UniProt:P04234 CD3D	3	p-Y149,Y160-CD3D [plasma membrane] (R-HSA-202329) CD3D [plasma membrane] (R-HSA-198171) CD3D [clathrin-coated endocytic vesicle membrane] (R-HSA-8869079)	0.483	2
UniProt:Q5JTV8 TOR1AIP1	1	TOR1AIP1 [cytosol] (R-HSA-9715083)	0.483	3
UniProt:Q4KMQ2 ANO6	3	ANO6 [tertiary granule membrane] (R-HSA-6800903) ANO6 [plasma membrane] (R-HSA-2684941) ANO6 [specific granule membrane] (R-HSA-6799509)	0.483	2
UniProt:Q8WVM8 SCFD1	1	SCFD1 [cytosol] (R-HSA-5688147)	0.483	3
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.483	3
UniProt:Q9HCU5 PREB	1	PREB [endoplasmic reticulum membrane] (R-HSA-203984)	0.483	3
UniProt:A0A0F6B1Q8 A0A0F6B1Q8			0.462	2
UniProt:P30050 RPL12	1	RPL12 [cytosol] (R-HSA-72408)	0.462	3

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