Transfer of Ub from E2 to substrate and release of E2

Stable Identifier
R-HSA-983140
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Interaction of E3 with both substrate and E2-Ub, brings them into proximity so that ubiquitin is transferred from E2 to the substrate. In most cases the transfer of ubiquitin is direct from E2 to substrate, but in a small subset of E3s, it occurs via a covalent E3-Ub thioester intermediate (Raymond et al. 2009).

Literature References
PubMed ID Title Journal Year
16954532 A novel family of membrane-bound E3 ubiquitin ligases

Ohmura-Hoshino, M, Goto, E, Matsuki, Y, Aoki, M, Mito, M, Uematsu, M, Hotta, H, Ishido, S

J Biochem 2006
12646216 U-box proteins as a new family of ubiquitin ligases

Hatakeyama, S, Nakayama, KI

Biochem Biophys Res Commun 2003
19489725 RING domain E3 ubiquitin ligases

Deshaies, RJ, Joazeiro, CA

Annu Rev Biochem 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of E3 ligases in proteasomal degradation [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created