Interaction of E3 with substrate and E2-Ub complex

Stable Identifier
R-HSA-983157
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Ubiquitin E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate (Raymond et al. 2009). E3 ligases includes a large, diverse set of proteins characterized by several defining motifs which include a HECT (homologous to E6-associated C-terminus), RING (Really Interesting New Gene) and U-box domains. The E3 ligases can be multisubunit complexes rather than a single polypeptide. Presently three different kinds of E3 complexes have been described called SCF, APC, and VHL. E3 ligases binds to both substrate and an E2 thioesterified with ubiquitin (E2-Ub).

Literature References
PubMed ID Title Journal Year
12646216 U-box proteins as a new family of ubiquitin ligases

Hatakeyama, S, Nakayama, KI

Biochem Biophys Res Commun 2003
16954532 A novel family of membrane-bound E3 ubiquitin ligases

Ohmura-Hoshino, M, Goto, E, Matsuki, Y, Aoki, M, Mito, M, Uematsu, M, Hotta, H, Ishido, S

J Biochem 2006
19489725 RING domain E3 ubiquitin ligases

Deshaies, RJ, Joazeiro, CA

Annu Rev Biochem 2009
19028597 Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system

Ebstein, F, Lange, N, Urban, S, Seifert, U, Kr├╝ger, E, Kloetzel, PM

Int. J. Biochem. Cell Biol. 2009
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