Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex

Stable Identifier
R-HSA-983161
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Upon peptide binding the class I MHC molecule releases from the peptide loading complex (PLC) and clusters at ER exit sites and is finally exported to the cell surface.
MHC I molecules bound to low-affinity peptides are not transferred to the cell surface and are instead cycled back to ER. They can proceed to the cell surface only when they become bound to high-affinity peptide (Howe et al. 2009, Garstka et al. 2007). Calreticulin binds to these low-affinity peptide bound class I molecules and mediate the retrieval from golgi apparatus to ER and for effcient presentation of a model antigen (Howe et al. 2009).

Literature References
PubMed ID Title Journal Year
19851281 Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules

Howe, C, Garstka, M, Al-Balushi, M, Ghanem, E, Antoniou, AN, Fritzsche, S, Jankevicius, G, Kontouli, N, Schneeweiss, C, Williams, A, Elliott, T, Springer, S

EMBO J 2009
2038058 Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution

Saper, MA, Bjorkman, PJ, Wiley, DC

J Mol Biol 1991
17656363 Peptide-receptive major histocompatibility complex class I molecules cycle between endoplasmic reticulum and cis-Golgi in wild-type lymphocytes

Garstka, M, Borchert, B, Al-Balushi, M, Praveen, PV, Kühl, N, Majoul, I, Duden, R, Springer, S

J Biol Chem 2007
16473882 Structural definition of the H-2Kd peptide-binding motif

Mitaksov, V, Fremont, DH

J Biol Chem 2006
21050182 The cell biology of major histocompatibility complex class I assembly: towards a molecular understanding

Van Hateren, A, James, E, Bailey, A, Phillips, A, Dalchau, N, Elliott, T

Tissue Antigens 2010
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