Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases

Stable Identifier
R-HSA-983162
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Some peptides generated by the 26S proteasome are too long to bind to MHC class I molecules. These N-terminal extended precursor peptides may be trimmed by cytosolic aminopeptidases, such as Tripeptidyl peptidase II (TPP2), puromycin-sensitive aminopeptidase (PSA), bleomycin hydrolase (BH), and leucine aminopeptidase (LAP).

Literature References
PubMed ID Title Journal Year
16849449 Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation

York, IA, Bhutani, N, Zendzian, S, Goldberg, AL, Rock, KL

J Immunol 2006
9668046 Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase

Beninga, J, Rock, KL, Goldberg, AL

J Biol Chem 1998
11062501 Two new proteases in the MHC class I processing pathway

Stoltze, L, Schirle, M, Schwarz, G, Schröter, C, Thompson, MW, Hersh, LB, Kalbacher, H, Stevanovic, S, Rammensee, HG, Schild, H

Nat Immunol 2000
15224091 Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII

Kloetzel, PM

Nat Immunol 2004
15224092 Post-proteasomal antigen processing for major histocompatibility complex class I presentation

Rock, KL, York, IA, Goldberg, AL

Nat Immunol 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aminopeptidase activity of IFN gamma stimulated aminopeptidases [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed