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KLC2 [cytosol]
Stable Identifier
R-HSA-983191
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Kinesin light chain 2, KLC2_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Kinesins (Homo sapiens)
Kinesin-1 is a heterotetramer (Homo sapiens)
KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
KLC2 [cytosol] (Homo sapiens)
Kinesin-1 [cytosol] (Homo sapiens)
KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
KLC2 [cytosol] (Homo sapiens)
Kinesins bind microtubules (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
Kinesin-1 [cytosol] (Homo sapiens)
KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
KLC2 [cytosol] (Homo sapiens)
Kinesins:microtubule [cytosol] (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
Kinesin-1 [cytosol] (Homo sapiens)
KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
KLC2 [cytosol] (Homo sapiens)
Kinesins move along microtubules consuming ATP (Homo sapiens)
Kinesins:microtubule [cytosol] (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
Kinesin-1 [cytosol] (Homo sapiens)
KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
KLC2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate KTN1 (Homo sapiens)
KTN1 binds Kinesin-1 (Homo sapiens)
Kinesin-1 [cytosol] (Homo sapiens)
KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
KLC2 [cytosol] (Homo sapiens)
RHOA,RHOG,RAC1,CDC42:GTP:KTN1:Kinesin-1 [endoplasmic reticulum membrane] (Homo sapiens)
Kinesin-1 [cytosol] (Homo sapiens)
KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
KLC2 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
Kinesins:microtubule [cytosol] (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
Kinesin-1 [cytosol] (Homo sapiens)
KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
KLC2 [cytosol] (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
Kinesins:microtubule [cytosol] (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
Kinesin-1 [cytosol] (Homo sapiens)
KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
KLC2 [cytosol] (Homo sapiens)
Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
Kinesins:microtubule [cytosol] (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
Kinesin-1 [cytosol] (Homo sapiens)
KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
KLC2 [cytosol] (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
Kinesins:microtubule [cytosol] (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
Kinesin-1 [cytosol] (Homo sapiens)
KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
KLC2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H0B6 KLC2
Gene Names
KLC2
Chain
chain:1-622
Reference Genes
BioGPS Gene:64837 KLC2
COSMIC (genes):KLC2 KLC2
CTD Gene:64837 KLC2
dbSNP Gene:64837 KLC2
ENSEMBL:ENSG00000174996 KLC2
HGNC:20716 KLC2
KEGG:hsa:64837 KLC2
Monarch:64837 KLC2
NCBI Gene:64837 KLC2
OMIM:611729 KLC2
UCSC:Q9H0B6 KLC2
Reference Transcript
RefSeq:NM_001134776.1 KLC2
RefSeq:NM_001318734.1 KLC2
RefSeq:XM_005274183.1 KLC2
RefSeq:NM_022822.2 KLC2
RefSeq:NM_001134774.1 KLC2
RefSeq:NM_001134775.1 KLC2
Other Identifiers
11741614_x_at
11755410_x_at
1557513_PM_a_at
1557513_a_at
16727324
218906_PM_x_at
218906_x_at
3336044
3336045
3336046
3336047
3336048
3336049
3336051
3336052
3336053
3336054
3336055
3336056
3336057
3336058
3336059
3336060
3336061
3336062
3336063
3336064
3336065
3336066
3336067
3336068
3336069
3336070
3336071
3336072
3336073
3336075
3336076
54439_at
64837
7941565
A_24_P227211
A_24_P926382
A_33_P3219895
A_33_P3288805
GE88516
GO:0005515
GO:0005654
GO:0005737
GO:0005739
GO:0005764
GO:0005765
GO:0005773
GO:0005829
GO:0005856
GO:0005871
GO:0005874
GO:0005886
GO:0007018
GO:0008092
GO:0016020
GO:0016938
GO:0019894
GO:0032418
GO:0032991
GO:0043226
GO:0045296
HMNXSV003032784
Hs2.327621.1.S1_3p_s_at
ILMN_1653470
ILMN_1774493
ILMN_1779064
PH_hs_0014454
TC11000656.hg
Participates
as a member of
KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
Inferred To
klc-1 [cytosol]
(Caenorhabditis elegans)
Klc2 [cytosol]
(Mus musculus)
Klc2 [cytosol]
(Rattus norvegicus)
klc-2 [cytosol]
(Caenorhabditis elegans)
Homologues of KLC2 [cytosol]
(Caenorhabditis elegans)
Klc [cytosol]
(Drosophila melanogaster)
KLC2 [cytosol]
(Bos taurus)
KLC2 [cytosol]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000394066
,
ENSP00000377630
,
ENST00000421552
,
ENSP00000377631
,
ENST00000394067
,
ENST00000316924
,
ENSP00000314837
,
ENSP00000408484
,
ENST00000417856
,
ENSP00000399403
OpenTargets
ENSG00000174996
HPA
ENSG00000174996-KLC2
PRO
Q9H0B6
Pharos - Targets
Q9H0B6
GlyGen
Q9H0B6
Orphanet
KLC2
PDB
3EDT
,
3CEQ
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.867
7
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.745
6
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.649
6
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.628
5
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-8S-N [cytosol]
(R-COV-9729335)
p-S188,206-N [cytosol]
(R-COV-9729324)
N [cytosol]
(R-COV-9694300)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
0.601
4
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.527
2
UniProt:O60645 EXOC3
2
EXOC3 [secretory granule membrane]
(R-HSA-2872286)
EXOC3 [cytosol]
(R-HSA-5623379)
0.527
2
UniProt:P05120 SERPINB2
2
SERPINB2 [plasma membrane]
(R-HSA-159004)
SERPINB2 [extracellular region]
(R-HSA-158997)
0.527
3
UniProt:O14977 AZIN1
1
AZIN1 [cytosol]
(R-HSA-350615)
0.527
2
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [plasma membrane]
(R-HSA-182955)
SH3KBP1 [cytosol]
(R-HSA-182957)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.527
2
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