Reactome: A Curated Pathway Database

Kinesin-1 is a heterotetramer

Stable Identifier
R-HSA-983194
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Kinesin-1 is a heterotetramer of two heavy chains (HCs) and two light chains (LCs). The HC tail binds microtubules and inhibits ATPase activity by interacting with the enzymatic HC heads. LCs regulate the head and microtubule-binding activities of the HC tail by reducing the affinity of the head-tail interaction over tenfold. By a separate mechanism LCs inhibit microtubule binding.

Literature References
Participants
Participant Of
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Orthologous Events