Kinesin-1 is a heterotetramer

Stable Identifier
R-HSA-983194
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Kinesin-1 is a heterotetramer of two heavy chains (HCs) and two light chains (LCs). The HC tail binds microtubules and inhibits ATPase activity by interacting with the enzymatic HC heads. LCs regulate the head and microtubule-binding activities of the HC tail by reducing the affinity of the head-tail interaction over tenfold. By a separate mechanism LCs inhibit microtubule binding.

Literature References
PubMed ID Title Journal Year
3134048 Native structure and physical properties of bovine brain kinesin and identification of the ATP-binding subunit polypeptide

Bloom, GS, Wagner, MC, Pfister, KK, Brady, ST

Biochemistry 1988
3130248 The quaternary structure of bovine brain kinesin

Kuznetsov, SA, Vaisberg, EA, Shanina, NA, Magretova, NN, Chernyak, VY, Gelfand, VI

EMBO J 1988
1607388 Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells

Navone, F, Niclas, J, Hom-Booher, N, Sparks, L, Bernstein, HD, McCaffrey, G, Vale, RD

J Cell Biol 1992
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