Reactome | KLC3 [cytosol]

KLC3 [cytosol]

Stable Identifier

R-HSA-983232

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Kinesin light chain 3, KLC3_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate KTN1 (Homo sapiens)
        
        KTN1 binds Kinesin-1 (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC3 [cytosol] (Homo sapiens)
        
        RHOA,RHOG,RAC1,CDC42:GTP:KTN1:Kinesin-1 [endoplasmic reticulum membrane] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC3 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC3 [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC3 [cytosol] (Homo sapiens)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC3 [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6P597 KLC3

Gene Names

KLC3, KLC2, KLC2L

Chain

chain:1-504

Reference Genes

BioGPS Gene:147700 KLC3

COSMIC (genes):KLC2 KLC2

COSMIC (genes):KLC3 KLC3

CTD Gene:147700 KLC3

dbSNP Gene:147700 KLC3

ENSEMBL:ENSG00000104892 KLC3

HGNC:20717 KLC3

KEGG:hsa:147700 KLC3

Monarch:147700 KLC3

NCBI Gene:147700 KLC3

OMIM:601334 KLC3

UCSC:Q6P597 KLC3

Reference Transcript

RefSeq:NM_177417.2 KLC3

Participates

as a candidate of

KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)

Inferred To

KLC3 [cytosol] (Bos taurus)

KLC3 [cytosol] (Canis familiaris)

KLC3 [cytosol] (Gallus gallus)

KLC3 [cytosol] (Sus scrofa)

klc-1 [cytosol] (Caenorhabditis elegans)

klc3 [cytosol] (Danio rerio)

klc-2 [cytosol] (Caenorhabditis elegans)

Klc3 [cytosol] (Mus musculus)

Klc3 [cytosol] (Rattus norvegicus)

klc1 [cytosol] (Xenopus tropicalis)

Klc [cytosol] (Drosophila melanogaster)

Homologues of KLC3 [cytosol] (Caenorhabditis elegans)

Cross References

ENSEMBL

ENSP00000436019, ENST00000391946, ENSP00000375810, ENST00000470402, ENSG00000104892, ENST00000585434, ENSP00000466067

OpenTargets

ENSG00000104892

GeneCards

KLC3

HPA

ENSG00000104892-KLC3

PRO

Q6P597

Pharos - Targets

Q6P597

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.744	4
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.669	4
UniProt:O43464 HTRA2	1	HTRA2 [mitochondrial intermembrane space] (R-HSA-56655)	0.556	3
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.556	3
UniProt:P54652 HSPA2	2	HSPA2 [cytosol] (R-HSA-3371408) HSPA2 [nucleoplasm] (R-HSA-912480)	0.556	3
UniProt:Q8N3I7 BBS5	1	BBS5 [cytosol] (R-HSA-5617633)	0.556	3
UniProt:Q9BTA9 WAC	1	WAC [nucleoplasm] (R-HSA-8942150)	0.556	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	2