Reactome | KLC4 [cytosol]

KLC4 [cytosol]

Stable Identifier

R-HSA-983244

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Kinesin light chain 4, KLC4_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate KTN1 (Homo sapiens)
        
        KTN1 binds Kinesin-1 (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC4 [cytosol] (Homo sapiens)
        
        RHOA,RHOG,RAC1,CDC42:GTP:KTN1:Kinesin-1 [endoplasmic reticulum membrane] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC4 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC4 [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC4 [cytosol] (Homo sapiens)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC4 [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)
        
        KLC4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NSK0 KLC4

Gene Names

KLC4, KNSL8

Chain

initiator methionine:, chain:2-619

Reference Genes

BioGPS Gene:89953 KLC4

COSMIC (genes):KLC4 KLC4

CTD Gene:89953 KLC4

dbSNP Gene:89953 KLC4

ENSEMBL:ENSG00000137171 KLC4

HGNC:21624 KLC4

KEGG:hsa:89953 KLC4

Monarch:89953 KLC4

NCBI Gene:89953 KLC4

UCSC:Q9NSK0 KLC4

Reference Transcript

Other Identifiers

11720267_a_at

11733641_a_at

1553675_PM_at

1553675_at

17008778

225596_PM_at

225596_at

2907624

2907626

2907630

2907631

2907632

2907633

2907634

2907635

2907636

2907637

2907639

2907640

2907641

2907642

2907643

2907644

2907645

2907646

2907647

2907648

2907649

2907650

2907652

2907653

2907654

2907656

2907657

2907658

2907659

2907660

2907661

2907662

2907663

2907664

2907665

2907666

2907667

2907672

2907673

2907674

42779_at

53055_s_at

8119670

89953

A_14_P121684

A_23_P133799

A_23_P397308

GE508200

GE56874

GE85090

GO:0005515

GO:0005737

GO:0005856

GO:0005871

GO:0005874

GO:0007018

GO:0008092

GO:0019894

GO:0043226

HMNXSV003027639

HMNXSV003058431

Hs.53447.0.A1_3p_at

Hs2.53447.1.S1_3p_at

ILMN_1687873

ILMN_1727199

ILMN_2258363

ILMN_2371152

PH_hs_0003546

PH_hs_0033185

TC06000594.hg

Participates

as a candidate of

KLC1,KLC2,KLC3,KLC4 [cytosol] (Homo sapiens)

Inferred To

klc-1 [cytosol] (Caenorhabditis elegans)

klc3 [cytosol] (Danio rerio)

klc-2 [cytosol] (Caenorhabditis elegans)

KLC4 [cytosol] (Bos taurus)

KLC4 [cytosol] (Canis familiaris)

KLC4 [cytosol] (Gallus gallus)

KLC4 [cytosol] (Sus scrofa)

Homologues of KLC4 [cytosol] (Caenorhabditis elegans)

klc1 [cytosol] (Xenopus tropicalis)

Klc [cytosol] (Drosophila melanogaster)

Klc4 [cytosol] (Mus musculus)

Klc4 [cytosol] (Rattus norvegicus)

Cross References

ENSEMBL

ENSP00000395806, ENST00000467906, ENST00000453940, ENSP00000418031, ENST00000479388, ENST00000347162, ENST00000458460, ENSP00000377620, ENSP00000418759, ENSP00000410358, ENSP00000259708, ENSP00000340221, ENST00000259708, ENST00000394056

OpenTargets

ENSG00000137171

HPA

ENSG00000137171-KLC4

PRO

Q9NSK0

Pharos - Targets

Q9NSK0

GlyGen

Q9NSK0

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.867	7
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.816	7
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.649	6
UniProt:O75478 TADA2A	1	TADA2A [nucleoplasm] (R-HSA-3662284)	0.556	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.556	3
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.471	4