Kinesins bind microtubules

Stable Identifier
R-HSA-983266
Type
Reaction
Species
Homo sapiens
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Summation

All kinesins contain a motor domain or head, the position varies but it is structurally highly conserved (Kull et al. 1996, Sablin et al. 1996). The microtubule-binding site includes structural elements which interact with tubulin and undergo movement between the ADP and ATP bound states. The highly conserved switch I (SSRSH) and II (DLAGSE) motifs, which change in conformation during the ATP hydrolysis cycle, form a salt-bridge that, in myosin, closes the nucleotide-binding cleft, enabling the motor to hydrolyze ATP (Geeves & Holmes 1999). This closed conformation has now been seen in a crystal structure of the frog kinesin-5 Eg5 (Parke et al. 2010).

Literature References
PubMed ID Title Journal Year
2521221 Isolation of a 45-kDa fragment from the kinesin heavy chain with enhanced ATPase and microtubule-binding activities

Kuznetsov, SA, Vaisberg, YA, Rothwell, SW, Murphy, DB, Gelfand, VI

J Biol Chem 1989
2522352 A three-domain structure of kinesin heavy chain revealed by DNA sequence and microtubule binding analyses

Yang, JT, Laymon, RA, Goldstein, LS

Cell 1989
1607388 Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells

Navone, F, Niclas, J, Hom-Booher, N, Sparks, L, Bernstein, HD, McCaffrey, G, Vale, RD

J Cell Biol 1992
19116309 Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules

Cai, S, Weaver, LN, Ems-McClung, SC, Walczak, CE

Mol Biol Cell 2009
7929562 A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally

Sekine, Y, Okada, Y, Noda, Y, Kondo, S, Aizawa, H, Takemura, R, Hirokawa, N

J Cell Biol 1994
15326200 Human chromokinesin KIF4A functions in chromosome condensation and segregation

Mazumdar, M, Sundareshan, S, Misteli, T

J Cell Biol 2004
16262723 Kinesin-2 is a motor for late endosomes and lysosomes

Brown, CL, Maier, KC, Stauber, T, Ginkel, LM, Wordeman, L, Vernos, I, Schroer, TA

Traffic 2005
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