Capturing cargo and formation of prebudding complex

Stable Identifier
R-HSA-983426
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The cytoplasmic tails of MHC class I molecules do not possess any of the known ER export sequences. BAP31 acts as a cargo receptor by exporting peptide-loaded class I MHC molecules to the ER exit sites or ER/Golgi intermediate compartment. Sec24 of the Sec23-Sec24/Sar1-GTP complex catches cargo by direct contact, forming the prebudding complex. Sar1/Sec23-Sec24 can bring about curvature of the membrane in the formation of vesicle. The cargo (antigen-bound MHC) accumulates within the COPII vesicle by binding to the Sec24 polypeptide of the COPII coat.

Literature References
PubMed ID Title Journal Year
11163199 Selective export of MHC class I molecules from the ER after their dissociation from TAP

Spiliotis, ET, Manley, H, Osorio, M, Zúñiga, MC, Edidin, M

Immunity 2000
10825291 COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites

Stephens, DJ, Lin-Marq, N, Pagano, A, Pepperkok, R, Paccaud, JP

J Cell Sci 2000
10982397 Dynamics of transitional endoplasmic reticulum sites in vertebrate cells

Hammond, AT, Glick, BS

Mol Biol Cell 2000
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