Reactome | K48polyUb-MAVS [mitochondrial outer membrane]

K48polyUb-MAVS [mitochondrial outer membrane]

Stable Identifier

R-HSA-983463

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

K48polyUb-IPS-1, K-48-polyubiquitinated IPS-1

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-1 Infection (Homo sapiens)
        
        SARS-CoV-1-host interactions (Homo sapiens)
        
        SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
        
        SARS-CoV-1 9b recruits ITCH to MAVS (Homo sapiens)
        
        9b:K48polyUb-MAVS:PCBP2:ITCH [mitochondrial outer membrane] (Homo sapiens)
        
        K48polyUb-MAVS [mitochondrial outer membrane] (Homo sapiens)

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
    - Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
      - Recruitment of ITCH and K48 ubiquitination of MAVS (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2:ITCH [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:K48polyUb-MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        K48polyUb-MAVS [mitochondrial outer membrane] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
19881509	PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4 Sun, W, Jiang, Z, You, F, Liang, S, Sun, H, Zhai, Z, Zhou, X	Nat Immunol	2009

External Reference Information

External Reference

UniProt:Q7Z434 MAVS

Gene Names

MAVS, IPS1, KIAA1271, VISA

Chain

chain:1-540

Reference Genes

BioGPS Gene:57506 MAVS

COSMIC (genes):MAVS MAVS

CTD Gene:57506 MAVS

dbSNP Gene:57506 MAVS

ENSEMBL:ENSG00000088888 MAVS

ENSEMBL_homo_sapiens_GENE:ENSG00000088888.18 MAVS

HGNC:29233 MAVS

KEGG Gene (Homo sapiens):57506 MAVS

Monarch:57506 MAVS

NCBI Gene:57506 MAVS

OMIM:609676 MAVS

UCSC:Q7Z434 MAVS

Reference Transcript

Other Identifiers

11727037_at

11727038_a_at

11727039_at

11727040_at

11748041_a_at

11748283_a_at

11752037_a_at

16911077

220305_PM_at

220305_at

226495_PM_at

226495_at

229741_PM_at

229741_at

231829_PM_at

231829_at

3874499

3874503

3874504

3874505

3874506

3874507

3874509

3874510

3874511

3874512

3874513

3874515

3874516

3874517

3874518

3874519

3874520

3874521

3874522

3874523

3874524

3874525

3874526

3874527

3874528

3874529

3874531

3874532

57506

59318_at

60021_at

60494_at

76826_at

80283_at

8060705

88885_at

A_19_P00319295

A_19_P00319465

A_19_P00329711

A_19_P00331109

A_19_P00812044

A_23_P68539

A_24_P164854

A_24_P928798

A_33_P3244021

A_33_P3244026

A_33_P3272527

GE538835

GE87674

GO:0000151

GO:0001934

GO:0002218

GO:0002230

GO:0002376

GO:0002735

GO:0002753

GO:0005515

GO:0005737

GO:0005739

GO:0005741

GO:0005777

GO:0005778

GO:0006351

GO:0006355

GO:0006886

GO:0006913

GO:0007031

GO:0007165

GO:0016020

GO:0019901

GO:0023052

GO:0031966

GO:0032481

GO:0032727

GO:0032728

GO:0032755

GO:0032757

GO:0032760

GO:0035591

GO:0036211

GO:0039552

GO:0042307

GO:0042742

GO:0042802

GO:0043123

GO:0043226

GO:0045071

GO:0045087

GO:0045944

GO:0050700

GO:0050896

GO:0051091

GO:0051607

GO:0060090

GO:0060337

GO:0060339

GO:0060340

GO:0060760

GO:0065003

GO:0070585

GO:0071360

GO:0071651

GO:0071660

GO:0098542

GO:0140374

GO:0140693

GO:1900063

GO:1900227

HMNXSV003055051

Hs.134883.0.A1_3p_at

Hs.183669.0.A1_3p_at

Hs.183669.1.A1_3p_at

ILMN_1800152

ILMN_2131493

PH_hs_0022531

PH_hs_0040123

PH_hs_0040592

TC20000043.hg

TC20001069.hg

g13128977_3p_at

Participates

as a component of

Other forms of this molecule

MAVS [mitochondrial outer membrane]

Modified Residues

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at 371

Coordinate

371

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at 420

Coordinate

420

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_065797.2, NP_001193420.1

OpenTargets

ENSG00000088888

HPA

ENSG00000088888-MAVS

GeneCards

Q7Z434

Ensembl

ENSP00000413749, ENSG00000088888, ENST00000428216, ENST00000416600, ENSP00000401980

PRO

Q7Z434

Pharos - Targets

Q7Z434

PDB

2VGQ, 3J6J, 4Z8M, 3J6C, 2MS7, 3RC5, 4P4H, 5JEK, 7DNI, 2MS8

Interactors (46)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95786 RIGI	4	PolyUb-DDX58 [cytosol] (R-HSA-6782770) K48polyUb-DDX58 [cytosol] (R-HSA-3080568) K63polyUb-DDX58 [cytosol] (R-HSA-918191) DDX58 [cytosol] (R-HSA-168917)	0.956	19
UniProt:Q86WV6 STING1	5	TMEM173 [plasma membrane] (R-HSA-6804815) TMEM173 [secretory granule membrane] (R-HSA-6804798) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) STING [endoplasmic reticulum membrane] (R-HSA-1834940)	0.839	9
UniProt:Q9BYX4 IFIH1	3	IFIH1 [cytosol] (R-HSA-913536) K48polyUb-IFIH1 [cytosol] (R-HSA-3080557) PolyUb-IFIH1 [cytosol] (R-HSA-6782812)	0.775	7
UniProt:Q14164 IKBKE	5	monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535) IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521)	0.77	4
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.742	5
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.733	11
UniProt:Q9UHD2 TBK1	5	pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-TBK1 [cytosol] (R-HSA-9008705) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) TBK1 [cytosol] (R-HSA-166267) p-S172-TBK1 [cytosol] (R-HSA-168379)	0.723	6
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.71	4
UniProt:P0DTD8 NS7B			0.632	3
UniProt:P00519 ABL1	6	p-Y393-ABL1 [cytosol] (R-HSA-9865161) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.591	6
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.589	5
UniProt:O43353 RIPK2	2	RIPK2 [cytosol] (R-HSA-168402) Ub-209-RIPK2 [cytosol] (R-HSA-706483)	0.576	3
UniProt:Q13137 CACO2			0.576	3
UniProt:P42224 STAT1	8	p-STAT1 [nucleoplasm] (R-HSA-8987140) p-STAT1 [cytosol] (R-HSA-8950418) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622)	0.576	3
UniProt:O14920 IKBKB	3	IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506)	0.564	2
UniProt:P36957 DLST	5	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) GlutaryllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9858581) DLST [mitochondrial matrix] (R-HSA-6792574)	0.556	3
UniProt:Q8TDX7 NEK7	2	p-S195-NEK7 [cytosol] (R-HSA-2984246) NEK7 [cytosol] (R-HSA-2530599)	0.556	3
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.556	3
UniProt:Q9Y2W7 KCNIP3	2	KCNIP3 [plasma membrane] (R-HSA-5577044) KCNIP3 [nucleoplasm] (R-HSA-9640052)	0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.556	3
UniProt:Q96P20 NLRP3	2	K63polyUb-NLRP3 [cytosol] (R-HSA-6783288) NLRP3 [cytosol] (R-HSA-561189)	0.556	4
IntAct:EBI-25890541 CCSB			0.556	3
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.556	3
UniProt:P0DTD1-PRO_0000449623 REP			0.544	2
UniProt:O00571 DDX3X	3	DDX3X [secretory granule lumen] (R-HSA-6801275) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273)	0.543	4
UniProt:P59636 9b	2	9b [mitochondrial outer membrane] (R-COV-9685182) 9b [cytosol] (R-COV-9689378)	0.543	5
UniProt:O75746 SLC25A12	2	SLC25A12 [mitochondrial intermembrane space] (R-HSA-1307794) SLC25A12 [mitochondrial inner membrane] (R-HSA-372470)	0.537	3
UniProt:Q9Y6E2 5MP1			0.527	2
UniProt:Q8TCT7 SPPL2B	1	SPPL2B [plasma membrane] (R-HSA-8863116)	0.527	2
UniProt:Q9Y664 KPTN	1	KPTN [lysosomal membrane] (R-HSA-9638238)	0.527	2
UniProt:Q08AM6 VAC14	3	VAC14 [Golgi membrane] (R-HSA-1806235) VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219)	0.527	2
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	3
UniProt:P00441 SOD1	5	SOD1 [extracellular region] (R-HSA-350705) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) 2xHC-SOD1 [cytosol] (R-HSA-3299726) SOD1 [cytosol] (R-HSA-350697)	0.527	2
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.527	2
UniProt:P38646 HSPA9	6	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993)	0.527	2
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.527	2
UniProt:Q6WB96 M22			0.524	4
UniProt:A2T3M4 NSP1			0.524	4
UniProt:Q9Y6K5 OAS3	1	OAS3 [cytosol] (R-HSA-1015672)	0.499	2
UniProt:P46379 BAG6	1	BAG6 [cytosol] (R-HSA-201567)	0.499	2
UniProt:Q7TFA1 NS7B			0.499	2
UniProt:Q14139 UBE4A	1	UBE4A [cytosol] (R-HSA-976022)	0.499	2
UniProt:Q13568 IRF5	3	p-S446-IRF5 [nucleoplasm] (R-HSA-9860304) p-S446-IRF5 [cytosol] (R-HSA-9860271) IRF5 [cytosol] (R-HSA-1015676)	0.499	2
UniProt:P27958 POLG	1	POLG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HCV-8854138)	0.463	2
UniProt:P0DTD2 9b	3	p-S53-9b [cytosol] (R-COV-9758478) 9b [cytosol] (R-COV-9694649) 9b [mitochondrial outer membrane] (R-COV-9709803)	0.463	2
UniProt:P42226 STAT6	6	p-S407,Y641-STAT6 [nucleoplasm] (R-HSA-3261241) p-S407,Y641-STAT6 [cytosol] (R-HSA-3249376) p-S407-STAT6 [cytosol] (R-HSA-3249369) STAT6 [cytosol] (R-HSA-629625) p-Y641-STAT6 [nucleoplasm] (R-HSA-6786279) p-Y641-STAT6 [cytosol] (R-HSA-6786109)	0.462	3

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