Reactome | p-Y188,Y199-CD79A [plasma membrane]

p-Y188,Y199-CD79A [plasma membrane]

Stable Identifier

R-HSA-983539

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

CD79A (Ig-alpha) with phosphotyrosine-188 and phsophotyrosine-199, C79A_HUMAN, CD79A

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        BTK binds BTK inhibitors (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
        
        BTK:BTK inhibitors [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Signaling by the B Cell Receptor (BCR) (Homo sapiens)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
      - BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Homo sapiens)
        
        BLNK (SLP-65) Signalosome [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
      - BTK autophosphorylates (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
      - BTK binds BTK inhibitors (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
        
        BTK:BTK inhibitors [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
      - LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
        
        PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
      - Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
      - Phosphorylated BTK phosphorylates PLCG2 (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
        
        BLNK (SLP-65) Signalosome [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
      - SYK autophosphorylates at the activated BCR (Homo sapiens)
        
        Antigen:p-BCR:SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
        
        PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
      - SYK binds the activated BCR (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
      - p-6Y-SYK phosphorylates BLNK (SLP65) (Homo sapiens)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
      - p-SYK and LYN phosphorylate BTK (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
        
        LYN, p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
    - CD22 mediated BCR regulation (Homo sapiens)
      - CD22 binds B-cell receptor (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
        
        CD22:Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
      - LYN phosphorylates CD22 (Homo sapiens)
        
        CD22:Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
        
        p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
      - SHP1 binds p-CD22 (Homo sapiens)
        
        PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)
        
        p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        Antigen:p-BCR [plasma membrane] (Homo sapiens)
        
        p-BCR [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD79A [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P11912 CD79A

Gene Names

CD79A, IGA, MB1

Chain

signal peptide:1-32, chain:33-226

Reference Genes

BioGPS Gene:973 CD79A

COSMIC (genes):CD79A CD79A

CTD Gene:973 CD79A

dbSNP Gene:973 CD79A

ENSEMBL:ENSG00000105369 CD79A

ENSEMBL_homo_sapiens_GENE:ENSG00000105369.10 CD79A

HGNC:1698 CD79A

KEGG Gene (Homo sapiens):973 CD79A

Monarch:973 CD79A

NCBI Gene:973 CD79A

OMIM:112205 CD79A

UCSC:P11912 CD79A

Reference Transcript

Other Identifiers

11719716_a_at

11741089_x_at

11754069_a_at

1555779_PM_a_at

1555779_a_at

16862604

205049_PM_s_at

205049_s_at

38017_at

38018_g_at

3834503

3834504

3834507

3834508

3834509

3834511

3834513

3834514

3834515

3834516

3834517

3834518

8029136

973

A_23_P107735

GE58879

GO:0002250

GO:0002376

GO:0004888

GO:0005515

GO:0005768

GO:0005771

GO:0005886

GO:0007166

GO:0009897

GO:0016020

GO:0019815

GO:0023052

GO:0030154

GO:0030183

GO:0031410

GO:0042100

GO:0042113

GO:0042802

GO:0043226

GO:0045121

GO:0048856

GO:0050853

GO:0060089

GO:0071755

HMNXSV003051314

Hs2.79630.3.S1_3p_s_at

ILMN_1659227

ILMN_1734878

ILMN_2410371

PH_hs_0004606

TC19000588.hg

U05259_rna1_at

g4502684_3p_a_at

Participates

as a component of

p-BCR [plasma membrane] (Homo sapiens)

Other forms of this molecule

CD79A [plasma membrane]

Inferred To

phospho-p-Y188,Y199-CD79A [plasma membrane] (Sus scrofa)

Homologues of p-Y188,Y199-CD79A [plasma membrane] (Canis familiaris)

phospho-Cd79a [plasma membrane] (Mus musculus)

phospho-Cd79a [plasma membrane] (Rattus norvegicus)

phospho-CD79A [plasma membrane] (Bos taurus)

phospho-CD79A [plasma membrane] (Canis familiaris)

Ghost homologue of p-Y188,Y199-CD79A [plasma membrane] (Gallus gallus)

Modified Residues

Name

O4'-phospho-L-tyrosine at 188

Coordinate

188

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 199

Coordinate

199

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_067612.1, NP_001774.1

OpenTargets

ENSG00000105369

GeneCards

P11912

HPA

ENSG00000105369-CD79A

Ensembl

ENSP00000400605, ENSP00000221972, ENST00000444740, ENSG00000105369, ENST00000221972

PRO

P11912

Pharos - Targets

P11912

Orphanet

18956

PDB

7XT6, 7XQ8, 7WSO, 1CV9, 7WSP

Interactors (43)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7L5A8 FA2H	1	FA2H [endoplasmic reticulum membrane] (R-HSA-5693771)	0.556	3
UniProt:Q969S0 SLC35B4	1	SLC35B4 [Golgi membrane] (R-HSA-742365)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P48065 SLC6A12	1	SLC6A12 [plasma membrane] (R-HSA-351969)	0.556	3
UniProt:P07204 THBD	1	THBD [plasma membrane] (R-HSA-141030)	0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:O15155 BET1	3	BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142) BET1 [transport vesicle] (R-HSA-6808719) BET1 [Golgi membrane] (R-HSA-6807743)	0.556	3
UniProt:Q86YT5 SLC13A5	1	SLC13A5 [plasma membrane] (R-HSA-433135)	0.556	3
UniProt:Q9H1C4 UNC93B1	4	UNC93B1 [Golgi membrane] (R-HSA-1679064) UNC93B1 [endoplasmic reticulum membrane] (R-HSA-1678930) UNC93B1 P345Pfs103 [endoplasmic reticulum membrane] (R-HSA-9628866) UNC93B1 L230Afs188 [endoplasmic reticulum membrane] (R-HSA-9628869)	0.556	3
UniProt:Q9Y6X1 SERP1	2	SERP1 [endoplasmic reticulum membrane] (R-HSA-381045) SERP1 [cytosol] (R-HSA-5250574)	0.556	3
UniProt:Q9Y5Z9 UBIAD1	1	UBIAD1 [endoplasmic reticulum membrane] (R-HSA-2980965)	0.556	3
UniProt:O75396 SEC22B	6	SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [Golgi membrane] (R-HSA-6810993)	0.556	3
UniProt:O14843 FFAR3	1	FFAR3 [plasma membrane] (R-HSA-443951)	0.556	3
UniProt:O43169 CYB5B	2	CYB5B [endoplasmic reticulum membrane] (R-HSA-9842695) CYB5B [mitochondrial outer membrane] (R-HSA-8943390)	0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:Q15836 VAMP3	6	VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.556	3
UniProt:Q13277 STX3	1	STX3 [plasma membrane] (R-HSA-449131)	0.556	3
UniProt:P46695 IER3	1	IER3 [cytosol] (R-HSA-6811515)	0.556	3
UniProt:P09601 HMOX1	4	HMOX1 [nucleoplasm] (R-HSA-9708567) HMOX1 [mitochondrial outer membrane] (R-HSA-9708524) HMOX1 [endoplasmic reticulum membrane] (R-HSA-189395) HMOX1 [cytosol] (R-HSA-9609901)	0.556	3
UniProt:Q8IY26 PLPP6	1	PLPP6 [plasma membrane] (R-HSA-8952144)	0.556	3
UniProt:O95406 CNIH1	3	CNIH1 [endoplasmic reticulum membrane] (R-HSA-5689439) CNIH1 [ER to Golgi transport vesicle membrane] (R-HSA-5689776) CNIH1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689778)	0.556	3
UniProt:P05090 APOD	1	APOD [extracellular region] (R-HSA-5216199)	0.556	3
UniProt:Q9UPQ8 DOLK	6	DOLK [endoplasmic reticulum membrane] (R-HSA-449274) DOLK M1I [endoplasmic reticulum membrane] (R-HSA-4755593) DOLK H408D [endoplasmic reticulum membrane] (R-HSA-4755548) DOLK C99S [endoplasmic reticulum membrane] (R-HSA-4755602) DOLK W304C [endoplasmic reticulum membrane] (R-HSA-4755557) DOLK Y441S [endoplasmic reticulum membrane] (R-HSA-4755590)	0.556	3
UniProt:Q9NTJ5 SACM1L	2	SACM1L [endoplasmic reticulum membrane] (R-HSA-1604637) SACM1L [Golgi membrane] (R-HSA-1806242)	0.556	3
UniProt:Q9H2H9 SLC38A1	1	SLC38A1 [plasma membrane] (R-HSA-212663)	0.556	6
UniProt:P37268 FDFT1	1	FDFT1 [endoplasmic reticulum membrane] (R-HSA-191369)	0.556	3
UniProt:Q15848 ADIPOQ	1	ADIPOQ [extracellular region] (R-HSA-1183052)	0.556	3
UniProt:P08100 RHO	8	RHO [ciliary membrane] (R-HSA-5623404) RHO [Golgi-associated vesicle membrane] (R-HSA-5623406) RHO [Golgi membrane] (R-HSA-5623400) 11c-retinyl-RHO [photoreceptor disc membrane] (R-HSA-5205900) at-retinyl-RHO [photoreceptor disc membrane] (R-HSA-5205901) p-S334,338,343-at-retinyl-RHO [photoreceptor disc membrane] (R-HSA-5205903) p-S334,338,343-RHO [photoreceptor disc membrane] (R-HSA-2581504) RHO [photoreceptor disc membrane] (R-HSA-419802)	0.556	3
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.556	3
UniProt:P08034 GJB1	2	GJB1 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190636) GJB1 [endoplasmic reticulum membrane] (R-HSA-190656)	0.556	3
UniProt:Q92685 ALG3	5	ALG3 [endoplasmic reticulum membrane] (R-HSA-449287) ALG3 W71R [endoplasmic reticulum membrane] (R-HSA-4720466) ALG3 G118D [endoplasmic reticulum membrane] (R-HSA-4720468) ALG3 M157K [endoplasmic reticulum membrane] (R-HSA-4720484) ALG3 R171Q [endoplasmic reticulum membrane] (R-HSA-4720470)	0.556	3
UniProt:Q14508 WFDC2	1	WFDC2 [extracellular region] (R-HSA-9830363)	0.556	3
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.556	3
UniProt:Q8WVV5 BTN2A2	1	BTN2A2 [plasma membrane] (R-HSA-8851047)	0.556	3
UniProt:Q9UKG4 SLC13A4	1	SLC13A4 [plasma membrane] (R-HSA-433098)	0.556	6
UniProt:Q5QGT7 RTP2	2	RTP2 [endoplasmic reticulum membrane] (R-HSA-9752982) RTP2 [plasma membrane] (R-HSA-8939446)	0.556	3
UniProt:P11686 SFTPC	9	pro-SFTPC P115L [endoplasmic reticulum membrane] (R-HSA-5688352) pro-SFTPC P30L [endoplasmic reticulum membrane] (R-HSA-5688365) pro-SFTPC [endoplasmic reticulum membrane] (R-HSA-5683842) pro-SFTPC [multivesicular body lumen] (R-HSA-5685298) SFTPC [extracellular region] (R-HSA-5683685) SFTPC [clathrin-coated endocytic vesicle] (R-HSA-5686342) SFTPC [lamellar body] (R-HSA-5683717) SFTPC(24-58) [multivesicular body lumen] (R-HSA-5685899) SFTPC(59-197) [multivesicular body lumen] (R-HSA-5685871)	0.556	3
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.556	3
UniProt:P17152 TMEM11	1	TMEM11 [mitochondrial inner membrane] (R-HSA-8949578)	0.556	3
UniProt:Q9UK39 NOCT	1	CCRN4L [nucleoplasm] (R-HSA-508391)	0.527	2
UniProt:O15121 DEGS1	3	DEGS1 [plasma membrane] (R-HSA-6806305) DEGS1 [specific granule membrane] (R-HSA-6799512) DEGS1 [endoplasmic reticulum membrane] (R-HSA-428201)	0.527	2
UniProt:P49590 HARS2	1	HARS2 [mitochondrial matrix] (R-HSA-379581)	0.527	2
UniProt:P29597 TYK2	5	p-TYK2 [cytosol] (R-HSA-8950424) p-Y-TYK2 [cytosol] (R-HSA-6784366) TYK2 [cytosol] (R-HSA-877348) p-Y1054,Y1055-TYK2 [cytosol] (R-HSA-909682) p-Y1054-TYK2 [cytosol] (R-HSA-1112598)	0.527	2