Reactome | BLK [cytosol]

BLK [cytosol]

Stable Identifier

R-HSA-983580

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine-protein kinase Blk, BLK_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P51451 BLK

Gene Names

BLK

Chain

initiator methionine:1, chain:2-505

Reference Genes

BioGPS Gene:640 BLK

COSMIC (genes):BLK BLK

CTD Gene:640 BLK

dbSNP Gene:640 BLK

ENSEMBL:ENSG00000136573 BLK

HGNC:1057 BLK

KEGG Gene (Homo sapiens):640 BLK

Monarch:640 BLK

NCBI Gene:640 BLK

OMIM:191305 BLK

UCSC:P51451 BLK

Reference Transcript

RefSeq:NM_001715.2 BLK

Other Identifiers

0005910215

11727346_a_at

11756075_x_at

17065750

206255_3p_at

206255_at

3085991

3086008

3086009

3086010

3086011

3086013

3086014

3086016

3086017

3086019

3086021

3086026

3086029

3086033

3086034

3086035

3086036

8144625

854_at

A_23_P31725

GE81061

GO:0000166

GO:0002376

GO:0003674

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006468

GO:0006810

GO:0007165

GO:0007169

GO:0007267

GO:0008150

GO:0008283

GO:0015031

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0030154

GO:0031234

GO:0032024

GO:0035556

GO:0038083

GO:0042127

GO:0043167

GO:0050853

GO:0050855

ILMN_1668277

S76617_at

TC08000087.hg

TC08001801.hg

g4502412_3p_s_at

Participant Of

output

BLK gene expression is stimulated by the complex of RUNX1 and ELF1, ELF2 or PAX5

Other forms of this molecule

MyrG2-BLK [plasma membrane]

Cross References

RefSeq

NP_001706.2

ZINC - World Drugs

BLK_HUMAN

OpenTargets

ENSG00000136573

ZINC - FDA approved

BLK_HUMAN

ZINC - Substances

BLK_HUMAN

ZINC target

P51451

ZINC - Biogenic

BLK_HUMAN

PRO

P51451

ZINC - Investigational

BLK_HUMAN

HPA

ENSG00000136573-BLK

GeneCards

P51451

Ensembl

ENSG00000136573, ENST00000259089, ENSP00000259089

ZINC - Predictions - Purchasable

BLK_HUMAN

Orphanet

19048

HMDB Protein

HMDBP01438

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40763 STAT3	10	p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [cytosol] (R-HSA-8982823) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.83	9
UniProt:O43281 EFS			0.712	5
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.692	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	2
UniProt:O75031 HSF2B			0.556	3
UniProt:Q96N16 JKIP1			0.556	3
UniProt:P51114-2 FXR1			0.556	3
UniProt:Q96Q35-2 FLACC1			0.556	5
UniProt:Q9BWW4 SSBP3			0.556	3
UniProt:Q9UJV3-2 MID2			0.556	3
UniProt:O14796 SH2D1B	1	SH2D1B [cytosol] (R-HSA-5685187)	0.556	3
UniProt:O43281-2 EFS			0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q92569 PIK3R3	2	K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574) PIK3R3 [cytosol] (R-HSA-205223)	0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:Q13490 BIRC2	5	K48pUb-BIRC2 [cytosol] (R-HSA-5675479) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2 [cytosol] (R-HSA-50847)	0.556	3
UniProt:Q13322-4 GRB10			0.556	3
UniProt:P49023-2 PXN			0.556	3
UniProt:O95551 TDP2	1	TDP2 [nucleoplasm] (R-HSA-5687253)	0.556	3
UniProt:P51116 FXR2			0.556	3
UniProt:P27986-2 PIK3R1			0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
UniProt:Q96BR9 ZBT8A			0.556	3
UniProt:P46109 CRKL	2	p-CRKL [cytosol] (R-HSA-9024730) CRKL [cytosol] (R-HSA-354384)	0.556	3
UniProt:O14543 SOCS3	1	SOCS3 [cytosol] (R-HSA-873794)	0.556	3
UniProt:Q6NX45 ZNF774	1	ZNF774 [nucleoplasm] (R-HSA-3110232)	0.556	3
UniProt:Q9UGK3 STAP2	2	STAP2 [cytosol] (R-HSA-8848028) p-Y250-STAP2 [plasma membrane] (R-HSA-8848079)	0.556	3
IntAct:EBI-22620261 CCSB ORF ID			0.556	3
IntAct:EBI-10171584 80125			0.556	3
UniProt:A0A0C4DGF1 A0A0C4DGF1			0.556	3
UniProt:B2RXF5 ZBT42			0.556	3
UniProt:Q13239-3 Q132393			0.556	3
UniProt:P06576 ATP5F1B	6	ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B [mitochondrial inner membrane] (R-HSA-1299441) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B [mitochondrial matrix] (R-HSA-164576)	0.527	2
UniProt:P08670 VIM	11	VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.499	3