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BLK [cytosol]
Stable Identifier
R-HSA-983580
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tyrosine-protein kinase Blk, BLK_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates transcription of genes involved in BCR signaling (Homo sapiens)
BLK gene expression is stimulated by the complex of RUNX1 and ELF1, ELF2 or PAX5 (Homo sapiens)
BLK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51451 BLK
Gene Names
BLK
Chain
initiator methionine:1, chain:2-505
Reference Genes
BioGPS Gene:640 BLK
COSMIC (genes):BLK BLK
CTD Gene:640 BLK
dbSNP Gene:640 BLK
ENSEMBL:ENSG00000136573 BLK
HGNC:1057 BLK
KEGG Gene (Homo sapiens):640 BLK
Monarch:640 BLK
NCBI Gene:640 BLK
OMIM:191305 BLK
UCSC:P51451 BLK
Reference Transcript
RefSeq:NM_001715.2 BLK
Other Identifiers
0005910215
11727346_a_at
11756075_x_at
17065750
206255_3p_at
206255_at
3085991
3086008
3086009
3086010
3086011
3086013
3086014
3086016
3086017
3086019
3086021
3086026
3086029
3086033
3086034
3086035
3086036
640
8144625
854_at
A_23_P31725
GE81061
GO:0000166
GO:0002376
GO:0002431
GO:0002513
GO:0002576
GO:0002902
GO:0003674
GO:0004672
GO:0004713
GO:0004715
GO:0005102
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0005886
GO:0006464
GO:0006468
GO:0006810
GO:0006950
GO:0006974
GO:0007155
GO:0007165
GO:0007169
GO:0007267
GO:0008150
GO:0008219
GO:0008283
GO:0015031
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0030154
GO:0030889
GO:0031175
GO:0031234
GO:0032024
GO:0035556
GO:0038083
GO:0042127
GO:0043167
GO:0043304
GO:0045087
GO:0048856
GO:0050853
GO:0050855
GO:0070667
GO:0090330
GO:0097028
GO:2000670
ILMN_1668277
S76617_at
TC08000087.hg
TC08001801.hg
g4502412_3p_s_at
Participant Of
output
BLK gene expression is stimulated by the complex of RUNX1 and ELF1, ELF2 or PAX5
Other forms of this molecule
MyrG2-BLK [plasma membrane]
Cross References
RefSeq
NP_001706.2
ZINC - World Drugs
BLK_HUMAN
OpenTargets
ENSG00000136573
ZINC - FDA approved
BLK_HUMAN
ZINC - Substances
BLK_HUMAN
ZINC - Biogenic
BLK_HUMAN
ZINC target
P51451
PRO
P51451
ZINC - Investigational
BLK_HUMAN
HPA
ENSG00000136573-BLK
GeneCards
P51451
Ensembl
ENST00000259089
,
ENSG00000136573
,
ENSP00000259089
Orphanet
19048
ZINC - Predictions - Purchasable
BLK_HUMAN
HMDB Protein
HMDBP01438
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40763 STAT3
10
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.83
9
UniProt:O43281 EFS
0.712
5
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.692
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
2
UniProt:O75031 HSF2B
0.556
3
UniProt:Q96N16 JKIP1
0.556
3
UniProt:P51114-2 FXR1
0.556
3
UniProt:Q96Q35-2 FLACC1
0.556
5
UniProt:Q9BWW4 SSBP3
0.556
3
UniProt:Q9UJV3-2 MID2
0.556
3
UniProt:O14796 SH2D1B
1
SH2D1B [cytosol]
(R-HSA-5685187)
0.556
3
UniProt:O43281-2 EFS
0.556
3
UniProt:Q92569 PIK3R3
2
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
PIK3R3 [cytosol]
(R-HSA-205223)
0.556
3
UniProt:Q9UKT9 IKZF3
0.556
3
UniProt:Q13490 BIRC2
5
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
BIRC2 [cytosol]
(R-HSA-50847)
0.556
3
UniProt:Q13322-4 GRB10
0.556
3
UniProt:P49023-2 PXN
0.556
3
UniProt:O95551 TDP2
1
TDP2 [nucleoplasm]
(R-HSA-5687253)
0.556
3
UniProt:P51116 FXR2
0.556
3
UniProt:P27986-2 PIK3R1
0.556
3
IntAct:EBI-16439879 CCSB ORF ID
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
PICK1 [plasma membrane]
(R-HSA-416989)
0.556
3
UniProt:O14543 SOCS3
1
SOCS3 [cytosol]
(R-HSA-873794)
0.556
3
UniProt:Q6NX45 ZNF774
1
ZNF774 [nucleoplasm]
(R-HSA-3110232)
0.556
3
UniProt:Q9UGK3 STAP2
2
STAP2 [cytosol]
(R-HSA-8848028)
p-Y250-STAP2 [plasma membrane]
(R-HSA-8848079)
0.556
3
IntAct:EBI-22620261 CCSB ORF ID
0.556
3
IntAct:EBI-10171584 80125
0.556
3
UniProt:P46109 CRKL
2
p-CRKL [cytosol]
(R-HSA-9024730)
CRKL [cytosol]
(R-HSA-354384)
0.556
3
UniProt:A0A0C4DGF1 A0A0C4DGF1
0.556
3
UniProt:B2RXF5 ZBT42
0.556
3
UniProt:Q13239-3 Q132393
0.556
3
UniProt:Q96BR9 ZBT8A
0.556
3
UniProt:P06576 ATP5F1B
6
ATP5B(1-47) [mitochondrial matrix]
(R-HSA-8986172)
ATP5B [mitochondrial inner membrane]
(R-HSA-1299441)
ATP5B(1-529) [mitochondrial inner membrane]
(R-HSA-1299440)
ATP5B(1-529) [mitochondrial intermembrane space]
(R-HSA-1267985)
ATP5B(1-529) [cytosol]
(R-HSA-1267973)
ATP5B [mitochondrial matrix]
(R-HSA-164576)
0.527
2
UniProt:P08670 VIM
11
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.499
3
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