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p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
Stable Identifier
R-HSA-9836400
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Microtubule-associated protein tau, Isoform Tau-F, TAU_HUMAN, Tau-F, Tau-4
Icon
Locations in the PathwayBrowser for interactor UniProt:P62081 RPS7
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
PKR-mediated signaling (Homo sapiens)
p-PKR dimer phosphorylates MAPT (Homo sapiens)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10636-8 MAPT
Gene Names
MAPT, MAPTL, MTBT1, TAU
Other Identifiers
113_i_at
114_r_at
11718731_a_at
11718732_a_at
11718733_a_at
11722667_a_at
11747246_a_at
11763486_a_at
16835016
203928_PM_x_at
203928_x_at
203929_PM_s_at
203929_s_at
203930_PM_s_at
203930_s_at
206401_PM_s_at
206401_s_at
225379_PM_at
225379_at
310_s_at
331_at
3723688
3723707
3723710
3723712
3723714
3723721
3723722
3723723
3723725
3723731
3723732
3723733
3723734
3723735
3723736
3723737
3723740
3723743
3723746
3723747
3723748
3723749
3723750
3723751
3723752
3723753
3723754
3723759
38629_at
4137
8007828
80210_at
A_14_P115066
A_14_P130889
A_14_P132491
A_21_P0014031
A_23_P207699
A_24_P224488
A_32_P95541
GE58740
GE86145
GO:0000226
GO:0001774
GO:0002376
GO:0003677
GO:0003680
GO:0003690
GO:0003697
GO:0003723
GO:0003779
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0006475
GO:0006914
GO:0006919
GO:0006954
GO:0006974
GO:0007005
GO:0007010
GO:0007018
GO:0007267
GO:0007416
GO:0007611
GO:0007613
GO:0008017
GO:0008092
GO:0008289
GO:0010288
GO:0010506
GO:0010629
GO:0010917
GO:0015630
GO:0015631
GO:0016020
GO:0016072
GO:0016607
GO:0017124
GO:0019896
GO:0019899
GO:0019901
GO:0021954
GO:0023052
GO:0030154
GO:0030424
GO:0030425
GO:0030426
GO:0030673
GO:0030674
GO:0031110
GO:0031113
GO:0031116
GO:0031122
GO:0031175
GO:0032930
GO:0033044
GO:0033673
GO:0034063
GO:0034185
GO:0034330
GO:0034399
GO:0034452
GO:0034605
GO:0034614
GO:0035091
GO:0036211
GO:0036464
GO:0036477
GO:0042802
GO:0042995
GO:0043005
GO:0043025
GO:0043197
GO:0043226
GO:0043565
GO:0044297
GO:0044304
GO:0045121
GO:0045298
GO:0045773
GO:0046785
GO:0048143
GO:0048167
GO:0048312
GO:0048699
GO:0048856
GO:0050808
GO:0050848
GO:0050877
GO:0051087
GO:0051258
GO:0051260
GO:0051721
GO:0051879
GO:0060090
GO:0061564
GO:0065003
GO:0070507
GO:0071813
GO:0072386
GO:0090140
GO:0090258
GO:0097386
GO:0097418
GO:0097435
GO:0098930
GO:0099077
GO:0099609
GO:1900034
GO:1900452
GO:1902474
GO:1902936
GO:1902988
GO:1903748
GO:1903829
GO:1904115
GO:1904428
GO:1905689
GO:1990000
GO:1990090
GO:1990416
HMNXSV003034099
Hs.101174.4.A1_3p_at
ILMN_1710903
ILMN_2298727
ILMN_2310814
J03778_s_at
PH_hs_0005629
TC17000592.hg
TC17002241.hg
TC17_ctg5_hap1000017.hg
X14474_at
X61373_at
g338684_3p_a_at
g8400712_3p_a_at
Participates
as an output of
p-PKR dimer phosphorylates MAPT (Homo sapiens)
Other forms of this molecule
p-S262,S356,S396-MAPT-8 [cytosol]
MAPT-8 [cytosol]
Inferred To
phospho-p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(Dictyostelium discoideum)
phospho-Mapt [cytosol]
(Mus musculus)
phospho-Mapt [cytosol]
(Rattus norvegicus)
phospho-MAPT [cytosol]
(Canis familiaris)
phospho-MAPT [cytosol]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-threonine at 181
Coordinate
181
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 199
Coordinate
199
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 202
Coordinate
202
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 231
Coordinate
231
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 262
Coordinate
262
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 396
Coordinate
396
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 404
Coordinate
404
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 409
Coordinate
409
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_058519.3
,
NP_058518.1
,
NP_001190181.1
,
NP_005901.2
,
NP_001116538.2
,
NP_058525.1
,
NP_001116539.1
ZINC - World Drugs
TAU_HUMAN
OpenTargets
ENSG00000186868
ZINC - FDA approved
TAU_HUMAN
ZINC - Substances
TAU_HUMAN
ZINC - Biogenic
TAU_HUMAN
ZINC target
P10636
PRO
P10636
PDB
5ZV3
,
8SEH
,
8Q8R
,
7QK2
,
8Q9G
,
7P68
,
7QKF
,
5ZIA
,
7QKZ
,
8OHP
,
8Q8X
,
3OVL
,
5E2W
,
8FUG
,
6GK7
,
7SP1
,
7NRS
,
8OTH
,
8Q99
,
8Q9I
,
7QJX
,
8Q8D
,
8BGS
,
6FBW
,
5N5B
,
7P6D
,
2ON9
,
8P34
,
6QJP
,
4Y5I
,
6TJX
,
8Q2L
,
6QJH
,
7UPE
,
8OI0
,
8ORG
,
7QKL
,
6BB4
,
5HF3
,
7EYC
,
7P65
,
8OPI
,
8Q98
,
7QKY
,
8PII
,
7QJW
,
8OHI
,
8Q9C
,
5DMG
,
6DCA
,
7P6C
,
8Q9M
,
7P67
,
8Q9F
,
7QJZ
,
8ORF
,
4GLR
,
7QKK
,
8OP0
,
6N4P
,
8Q9E
,
8Q8C
,
5MO3
,
7YPG
,
8Q8W
,
7QK6
,
6QJM
,
6DC8
,
5MP5
,
8G58
,
8CAX
,
5MP3
,
8Q7L
,
6QJQ
,
7QL3
,
5N5A
,
6PXR
,
7PQP
,
8Q2K
,
7U0Z
,
7QL4
,
7QK1
,
8Q7M
,
6CVJ
,
5O3T
,
8OT9
,
8Q9K
,
6VH7
,
8Q8M
,
8QCR
,
7NRX
,
7R5H
,
8Q7F
,
6HRF
,
8Q8L
,
7NRQ
,
5O3L
,
4NP8
,
6NWP
,
8Q8F
,
8QJJ
,
7QKU
,
8ORE
,
8OTJ
,
6ODG
,
7QJV
,
8Q9B
,
7R4T
,
6GK8
,
8Q27
,
7QK5
,
8OTG
,
8Q88
,
6FI5
,
6LRA
,
8Q9D
,
7QKX
,
8Q7T
,
7MKG
,
7UPG
,
6HRE
,
6CVN
,
7NRV
,
4Y3B
,
8Q97
,
5V5C
,
6XLI
,
7KQK
,
7P6B
,
4E0O
,
8G55
,
8Q8U
,
6VI3
,
7QKH
,
7MKH
,
8OH2
,
5O3O
,
8R3T
,
8BYN
,
8KDX
,
6TJO
,
8Q8Z
,
7QL2
,
6NWQ
,
7QKI
,
4E0M
,
8Q2J
,
6GX5
,
8AZU
,
8Q8Y
,
8Q8E
,
8BGV
,
7MKF
,
8Q9H
,
7QK3
,
8OTC
,
4E0N
,
7QKV
,
8G54
,
6VHA
,
7QL0
,
8Q9L
,
8CAQ
,
7QKG
,
7PQC
,
8Q7P
,
7QJY
,
7QKW
,
5NVB
,
8Q9A
,
4Y32
,
7P6A
,
7P6E
,
7QKM
,
7YMN
,
8OTI
,
4TQE
,
5K7N
,
8SEI
,
7QKJ
,
5MP1
,
8FYU
,
2MZ7
,
8OT6
,
1I8H
,
6DC9
,
7NRT
,
8FNZ
,
7P66
,
8Q8V
,
4FL5
,
6NK4
,
5V5B
,
7QL1
,
8Q9J
,
5E2V
,
8Q8S
,
6H06
,
8PPO
,
7UPF
,
8QCP
,
8Q92
,
8Q9O
,
6VHL
ZINC - Investigational
TAU_HUMAN
ZINC - Metabolites
TAU_HUMAN
HPA
ENSG00000186868-MAPT
GeneCards
P10636
Ensembl
ENST00000703922
,
ENST00000620818
,
ENSP00000515557
,
ENSP00000408975
,
ENSP00000479142
,
ENSP00000443028
,
ENST00000574436
,
ENST00000622728
,
ENSP00000481769
,
ENST00000334239
,
ENST00000628393
,
ENSG00000276155
,
ENSP00000483784
,
ENSP00000487819
,
ENSP00000413056
,
ENSP00000482244
,
ENSP00000303214
,
ENST00000613360
,
ENSP00000410838
,
ENST00000634049
,
ENSP00000487570
,
ENST00000351559
,
ENSP00000505258
,
ENST00000621329
,
ENSG00000186868
,
ENSP00000458742
,
ENST00000680542
,
ENST00000571987
,
ENSP00000488373
,
ENST00000633047
,
ENSP00000484491
,
ENST00000415613
,
ENST00000703924
,
ENSP00000487837
,
ENSP00000515558
,
ENSP00000389250
,
ENST00000612872
,
ENSP00000515559
,
ENST00000420682
,
ENST00000703978
,
ENSP00000484321
,
ENSP00000478602
,
ENSP00000477703
,
ENSP00000515600
,
ENST00000620981
,
ENST00000626571
,
ENST00000620070
,
ENST00000631447
,
ENST00000431008
,
ENST00000703923
,
ENSP00000460965
,
ENSP00000488245
,
ENST00000535772
,
ENSG00000277956
,
ENST00000446361
,
ENST00000632500
,
ENSP00000334886
,
ENST00000622106
,
ENSP00000486039
Pharos - Targets
P10636
ZINC - Predictions - Purchasable
TAU_HUMAN
Orphanet
16379
Interactors (30)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.749
8
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.723
8
UniProt:P05067-PRO_0000000092 APP
0.71
5
UniProt:P10636 MAPT
3
MAPT(422-758) [cytosol]
(R-HSA-350642)
MAPT(2-421) [cytosol]
(R-HSA-350628)
MAPT [cytosol]
(R-HSA-201574)
0.673
3
UniProt:P11142 HSPA8
10
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.667
6
UniProt:P49841 GSK3B
4
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [nucleoplasm]
(R-HSA-2022823)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [cytosol]
(R-HSA-2997551)
0.656
4
IntAct:EBI-4399559 UBIQ
0.641
3
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.589
3
UniProt:O43583 DENR
0.564
2
UniProt:Q8TCE9 PPL13
0.556
3
UniProt:O15195-2 O151952
0.556
3
UniProt:Q92608-2 Q926082
0.556
3
UniProt:Q9HC96 CAPN10
1
CAPN10 [cytosol]
(R-HSA-8848640)
0.556
3
UniProt:Q9C0A1 ZFHX2
0.556
3
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.547
2
UniProt:P02649-PRO_0000001987 APOE
0.544
3
UniProt:P51674 GPM6A
0.527
2
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.524
2
UniProt:P46779 RPL28
1
RPL28 [cytosol]
(R-HSA-72444)
0.499
4
UniProt:Q9UNE7-1 STUB1
0.499
5
UniProt:Q9UPY8 MARE3
0.499
3
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.499
2
UniProt:P04156 PRNP
2
PRNP [cytosol]
(R-HSA-9617597)
PRNP [plasma membrane]
(R-HSA-375060)
0.499
2
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.483
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.483
2
UniProt:Q9NY61 AATF
1
AATF [cytosol]
(R-HSA-205071)
0.471
2
UniProt:P07237 P4HB
3
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
0.463
2
UniProt:P43004 SLC1A2
1
SLC1A2 [plasma membrane]
(R-HSA-210459)
0.462
4
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