Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-S225-SPHK1 [nucleoplasm]
Stable Identifier
R-HSA-9836613
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antimicrobial mechanism of IFN-stimulated genes (Homo sapiens)
PKR-mediated signaling (Homo sapiens)
p-PKR dimer phosphorylates SPHK1 (Homo sapiens)
p-S225-SPHK1 [nucleoplasm] (Homo sapiens)
p-S225-SPHK1 localizes to cytosol (Homo sapiens)
p-S225-SPHK1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NYA1 SPHK1
Gene Names
SPHK1, SK1, SPHK, SPK
Chain
chain:1-384
Reference Genes
BioGPS Gene:8877 SPHK1
COSMIC (genes):SPHK1 SPHK1
CTD Gene:8877 SPHK1
dbSNP Gene:8877 SPHK1
ENSEMBL:ENSG00000176170 SPHK1
HGNC:11240 SPHK1
KEGG:hsa:8877 SPHK1
Monarch:8877 SPHK1
NCBI Gene:8877 SPHK1
OMIM:603730 SPHK1
UCSC:Q9NYA1 SPHK1
Reference Transcript
RefSeq:NM_001142601.2 SPHK1
RefSeq:NM_001142602.2 SPHK1
RefSeq:NM_001355139.2 SPHK1
RefSeq:NM_182965.3 SPHK1
RefSeq:XM_005257766.2 SPHK1
RefSeq:NM_021972.3 SPHK1
Participates
as an output of
p-PKR dimer phosphorylates SPHK1 (Homo sapiens)
as an input of
p-S225-SPHK1 localizes to cytosol (Homo sapiens)
Other forms of this molecule
p-S225-SPHK1 [cytosol]
SPHK1 [nucleoplasm]
SPHK1 [cytosol]
Inferred To
phospho-LCB5 [nucleoplasm]
(Saccharomyces cerevisiae)
phospho-Sphk1 [nucleoplasm]
(Mus musculus)
phospho-Sphk1 [nucleoplasm]
(Rattus norvegicus)
phospho-lcb4 [nucleoplasm]
(Schizosaccharomyces pombe)
phospho-SPHK1 [nucleoplasm]
(Bos taurus)
phospho-SPHK1 [nucleoplasm]
(Canis familiaris)
phospho-SPHK1 [nucleoplasm]
(Gallus gallus)
phospho-SPHK1 [nucleoplasm]
(Sus scrofa)
phospho-sphk1 [nucleoplasm]
(Xenopus tropicalis)
phospho-tim54 [nucleoplasm]
(Schizosaccharomyces pombe)
phospho-sphk-1 [nucleoplasm]
(Caenorhabditis elegans)
phospho-sgkC [nucleoplasm]
(Dictyostelium discoideum)
phospho-sgkB [nucleoplasm]
(Dictyostelium discoideum)
Homologues of p-S225-SPHK1 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of p-S225-SPHK1 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of p-S225-SPHK1 [nucleoplasm]
(Schizosaccharomyces pombe)
phospho-LCB4 [nucleoplasm]
(Saccharomyces cerevisiae)
phospho-Sk1 [nucleoplasm]
(Drosophila melanogaster)
phospho-TIM54 [nucleoplasm]
(Saccharomyces cerevisiae)
phospho-sgkA [nucleoplasm]
(Dictyostelium discoideum)
Modified Residues
Name
O-phospho-L-serine at 225
Coordinate
225
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001342068.1
,
NP_068807.2
,
NP_001136074.1
,
NP_892010.2
,
XP_005257823.1
,
NP_001136073.1
Guide to Pharmacology - Targets
2204
OpenTargets
ENSG00000176170
ENSEMBL
ENSP00000440970
,
ENST00000592299
,
ENSP00000468547
,
ENST00000545180
,
ENSP00000313681
,
ENST00000590959
,
ENST00000392496
,
ENSG00000176170
,
ENSP00000376285
,
ENSP00000465726
,
ENST00000323374
ZINC - Substances
SPHK1_HUMAN
ZINC - Biogenic
SPHK1_HUMAN
ZINC target
Q9NYA1
PRO
Q9NYA1
PDB
4L02
,
4V24
,
3VZC
,
3VZB
,
3VZD
ZINC - Investigational
SPHK1_HUMAN
ZINC - Metabolites
SPHK1_HUMAN
HPA
ENSG00000176170-SPHK1
GeneCards
SPHK1
Pharos - Targets
Q9NYA1
ZINC - Predictions - Purchasable
SPHK1_HUMAN
HMDB Protein
HMDBP01082
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q2M3C7 SPKAP
0.602
4
UniProt:P68104 EEF1A1
7
EEF1A1 [lysosomal membrane]
(R-HSA-9626022)
EEF1A1 [cytosol]
(R-HSA-156905)
EEF1A1 [secretory granule lumen]
(R-HSA-6801479)
EEF1A1 [extracellular region]
(R-HSA-6806456)
EEF1A1 [ficolin-1-rich granule lumen]
(R-HSA-6801528)
Me3K318-EEF1A1 [cytosol]
(R-HSA-8932419)
Me3K79-EEF1A1 [cytosol]
(R-HSA-8932212)
0.544
2
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.543
7
UniProt:Q96PQ7 KLHL5
1
KLHL5 [cytosol]
(R-HSA-8863223)
0.482
2
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text