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p-S225-SPHK1 [nucleoplasm]
Stable Identifier
R-HSA-9836613
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
PKR-mediated signaling (Homo sapiens)
p-PKR dimer phosphorylates SPHK1 (Homo sapiens)
p-S225-SPHK1 [nucleoplasm] (Homo sapiens)
p-S225-SPHK1 localizes to cytosol (Homo sapiens)
p-S225-SPHK1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NYA1 SPHK1
Gene Names
SPHK1, SK1, SPHK, SPK
Chain
chain:1-384
Reference Genes
COSMIC (genes):SPHK1 SPHK1
dbSNP Gene:8877 SPHK1
ENSEMBL:ENSG00000176170 SPHK1
Participates
as an output of
p-PKR dimer phosphorylates SPHK1 (Homo sapiens)
as an input of
p-S225-SPHK1 localizes to cytosol (Homo sapiens)
Other forms of this molecule
SPHK1 [nucleoplasm]
p-S225-SPHK1 [cytosol]
SPHK1 [cytosol]
Inferred To
phospho-p-S225-SPHK1 [nucleoplasm]
(Caenorhabditis elegans)
phospho-p-S225-SPHK1 [nucleoplasm]
(Dictyostelium discoideum)
phospho-p-S225-SPHK1 [nucleoplasm]
(Mus musculus)
phospho-p-S225-SPHK1 [nucleoplasm]
(Rattus norvegicus)
phospho-p-S225-SPHK1 [nucleoplasm]
(Saccharomyces cerevisiae)
phospho-p-S225-SPHK1 [nucleoplasm]
(Schizosaccharomyces pombe)
phospho-Sk1 [nucleoplasm]
(Drosophila melanogaster)
phospho-SPHK1 [nucleoplasm]
(Bos taurus)
phospho-SPHK1 [nucleoplasm]
(Canis familiaris)
phospho-SPHK1 [nucleoplasm]
(Gallus gallus)
phospho-SPHK1 [nucleoplasm]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 225
Coordinate
225
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q2M3C7 SPKAP
0.602
4
UniProt:P68104 EEF1A1
7
EEF1A1 [lysosomal membrane]
(R-HSA-9626022)
EEF1A1 [cytosol]
(R-HSA-156905)
EEF1A1 [secretory granule lumen]
(R-HSA-6801479)
EEF1A1 [extracellular region]
(R-HSA-6806456)
EEF1A1 [ficolin-1-rich granule lumen]
(R-HSA-6801528)
Me3K318-EEF1A1 [cytosol]
(R-HSA-8932419)
Me3K79-EEF1A1 [cytosol]
(R-HSA-8932212)
0.544
2
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.543
7
UniProt:Q96PQ7 KLHL5
1
KLHL5 [cytosol]
(R-HSA-8863223)
0.482
2
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