SYK binds the activated BCR

Stable Identifier
R-HSA-983700
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Recruitment of SYK to the Activated B Cell Receptor
Locations in the PathwayBrowser
Summation

The SYK protein tyrosine kinase binds specifically to phosphorylated immunoreceptor tyrosine-activated motifs (ITAMs) on Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) (Law et al. 1994, Saouaf et al. 1995, Rowley et al. 1995, Tsang et al. 2008). The binding activates the kinase activity of SYK (Rowley et al. 1995, Tsang et al. 2008).

Participants
Participant Of
Orthologous Events
Authored
Reviewed