SYK binds the activated BCR

Stable Identifier
R-HSA-983700
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Recruitment of SYK to the Activated B Cell Receptor
Locations in the PathwayBrowser
Summation

The SYK protein tyrosine kinase binds specifically to phosphorylated immunoreceptor tyrosine-activated motifs (ITAMs) on Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) (Law et al. 1994, Saouaf et al. 1995, Rowley et al. 1995, Tsang et al. 2008). The binding activates the kinase activity of SYK (Rowley et al. 1995, Tsang et al. 2008).

Literature References
PubMed ID Title Journal Year
7592958 Reconstitution of the B cell antigen receptor signaling components in COS cells

Saouaf, SJ, Kut, SA, Fargnoli, J, Rowley, RB, Bolen, JB, Mahajan, S

J Biol Chem 1995
7538118 Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation

Rowley, RB, Burkhardt, AL, Chao, HG, Matsueda, GR, Bolen, JB

J Biol Chem 1995
18818202 Molecular mechanism of the Syk activation switch

Tsang, E, Giannetti, AM, Shaw, D, Dinh, M, Tse, JK, Gandhi, S, Ho, H, Wang, S, Papp, E, Bradshaw, JM

J Biol Chem 2008
8163536 Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex

Law, CL, Sidorenko, SP, Chandran, KA, Draves, KE, Chan, AC, Weiss, A, Edelhoff, S, Disteche, CM, Clark, EA

J Biol Chem 1994
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