p-6Y-SYK phosphorylates BLNK (SLP65)

Stable Identifier
R-HSA-983703
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

BLNK (SLP-65, BASH) forms a stable complex with GRB2, SOS1, and CIN85 in the cytosol. The complex is recruited to the plasma membrane where activated (phosphorylated) SYK phosphorylates BLNK at tyrosines 72, 84, 96, 178, and 189 (Fu et al. 1998, Chiu et al. 2002, inferred from mouse in Wienands et al. 1998, from chicken in Oellerich et al. 2009). Phosphorylated BLNK serves as a scaffold that binds effector molecules such as Phospholipase C. As inferred from mouse, BLNK interacts with phosphorylated tyrosines on CD79A (Ig-alpha) (Engels et al. 2001, Kabak et al. 2002).

Literature References
PubMed ID Title Journal Year
11449366 Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha

Engels, N, Wollscheid, B, Wienands, J

Eur J Immunol 2001
11909947 The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways

Kabak, S, Skaggs, BJ, Gold, MR, Affolter, M, West, KL, Foster, MS, Siemasko, K, Chan, AC, Aebersold, R, Clark, MR

Mol Cell Biol 2002
11071869 Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes

Watanabe, S, Take, H, Takeda, K, Yu, ZX, Iwata, N, Kajigaya, S

Biochem Biophys Res Commun 2000
9705962 SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation

Wienands, J, Schweikert, J, Wollscheid, B, Jumaa, H, Nielsen, PJ, Reth, M

J Exp Med 1998
9341187 Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation

Fu, C, Chan, AC

J Biol Chem 1997
19372136 SLP-65 phosphorylation dynamics reveals a functional basis for signal integration by receptor-proximal adaptor proteins

Oellerich, T, Grønborg, M, Neumann, K, Hsiao, HH, Urlaub, H, Wienands, J

Mol Cell Proteomics 2009
12456653 BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

Chiu, CW, Dalton, M, Ishiai, M, Kurosaki, T, Chan, AC

EMBO J 2002
9697839 BLNK: a central linker protein in B cell activation

Fu, C, Turck, CW, Kurosaki, T, Chan, AC

Immunity 1998
21822214 The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85

Oellerich, T, Bremes, V, Neumann, K, Bohnenberger, H, Dittmann, K, Hsiao, HH, Engelke, M, Schnyder, T, Batista, FD, Urlaub, H, Wienands, J

EMBO J 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Antigen:p-BCR:p-SYK [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created